Solid phase extraction (SPE) is a technique designed for rapid, selective sample preparation and purification prior to chromatographic analysis. Using liquid chromatography principles to control selectivity, SPE provides the sample clean-up, recovery, and concentration necessary for accurate quantitative analysis. The multitude of available phase chemistries can be packed into an array of hardware formats such as glass tubes, 96-well plates, Büchner funnels and dispersive SPE, and can be processed using dedicated vacuum manifold accessories.