The Enzyme Explorer Apoptosis table is organized by your enzyme of interest. Under each
enzyme category are listed the corresponding enzymes, substrates, inhibitors and antibodies
offered by Sigma. This is only a partial list of reagents Sigma offers for apoptosis research.
For additional proteins, antibodies and reagents be sure to visit our Apoptosis pages in our Cell
Signaling section.
| Caspases (general)
|
|
|
| Product Name |
Detection |
Product # |
| Enzyme Combinations |
|
|
| Caspase Combo I, Type 1, 4, and 5 |
|
C8107 |
| Caspase Combo II, Type 2, 3, and 7 |
|
C8232 |
| Caspase Combo III, Type 6, 8, 9 and 10 human |
|
C8357 |
| General Caspase Inhibitors |
|
|
| Biotin-Val-Ala-Asp(OMe)-fluoromethyl ketone |
|
B2057 |
| Boc-Asp(OMe)-fluoromethyl ketone |
|
B2682 |
| Z-Ala-Glu(OMe)-Val-Asp(OMe)-fluoromethyl ketone |
|
C8484 |
| Z-Val-Lys(Biotin)-Asp(OMe)-fluoromethyl ketone |
|
C8609 |
| General Caspase Substrates |
|
|
| N-Acetyl-Val-Ala-Asp p-nitroanilide |
colorimetric |
A0848 |
| N-Acetyl-Val-Ala-Asp-7-amido-4-trifluoromethylcoumarin |
fluorimetric |
A0723 |
| L-Asp-Asp-Rhodamine trifluoroacetate salt |
fluorimetric |
D5189 |
| Caspase 1 |
|
back to top |
| Product Name |
Detection |
Product # |
| Enzyme |
|
|
| Caspase 1 human |
|
C5482 |
| Inhibitors |
|
|
| N-Acetyl-Trp-Glu-His-Asp-al |
|
A1466 |
| Interleukin-1b (IL-1b) Converting Enzyme (ICE) Inhibitor II |
|
A4211 |
| N-Acetyl-Tyr-Val-Lys(biotinyl)-Asp 2,6-dimethylbenzoyloxymethyl ketone |
|
A4339 |
| Z-Leu-Glu(OMe)-Val-Asp(OMe)-fluoromethyl ketone |
|
C9484 |
| Substrates |
|
|
| N-Acetyl-Tyr-Val-Ala-Asp p-nitroanilide |
colorimetric |
A3831 |
| N-Acetyl-Trp-Glu-His-Asp-p-nitroanilide |
colorimetric |
A6845 |
| N-Acetyl-Trp-Glu-His-Asp-7-amido-4-methylcoumarin |
fluorimetric |
A0216 |
| N-Acetyl-Tyr-Val-Ala-Asp-7-amido-4-methylcoumarin |
fluorimetric |
A2452 |
| N-Acetyl-Trp-Glu-His-Asp-7-amide-4-trifluoromethylcoumarin |
fluorimetric |
A6720 |
| N-Acetyl-Tyr-Val-Ala-Asp-7-amido-4-trifluoromethylcoumarin |
fluorimetric |
A9965 |
| 7-Methoxycoumarin-4-acetyl-Tyr-Val-Ala-Asp-Ala-Pro-(2,4-dinitrophenyl)Lys |
fluorimetric |
M5295 |
| Antibodies |
|
|
| Anti-Caspase 1 (ICE) from rabbit |
|
C4851 |
| Caspase 2 |
|
back to top |
| Product Name |
Detection |
Product # |
| Enzyme |
|
|
| Caspase 2 human |
|
C2854 |
| Inhibitors |
|
|
| N-Acetyl-Val-Asp-Val-Ala-Asp-CHO |
|
A2222 |
| Z-Val-Asp(O-Me)-Val-Ala-Asp(O-Me) fluoromethyl ketone |
|
C1605 |
| Substrates |
|
|
| N-Acetyl-Val-Asp-Val-Ala-Asp-p-nitroanilide |
colorimetric |
A5470 |
| N-Acetyl-Val-Asp-Val-Ala-Asp-7-amido-4-trifluoromethylcoumarin |
fluorimetric |
A5345 |
| Antibodies |
|
|
| Anti-Caspase 2 from rabbit |
|
C7349 |
| Caspase 3 |
|
back to top |
| Product Name |
Detection |
Product # |
| Enzymes |
|
|
| Caspase 3 human |
|
C1224 |
| Procaspase-3 human |
|
P1488 |
| Inhibitors |
|
|
| N-Acetyl-Asp-Glu-Val-Asp-al |
|
A0835 |
| N-Acetyl-Ile-Glu-Thr-Asp-al |
|
A1216 |
| N-Acetyl-Glu-Ser-Met-Asp-al |
|
A1341 |
| Biotin-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethyl ketone |
|
B1807 |
| Z-Asp(OMe)-Gln-Met-Asp(OMe) fluoromethyl ketone |
|
C0480 |
| N-Acetyl-Leu-Glu-Val-Asp-CHO trifluoroacetate salt |
|
C0859 |
| Z-VAD-FMK |
|
V-116 |
| Substrates |
|
|
| N-Acetyl-Asp-Glu-Val-Asp p-nitroanilide |
colorimetric |
A2559 |
| N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-trifluoromethylcoumarin |
fluorimetric |
A0466 |
| Acetyl-Asp-Glu-Val-Asp-7-amido-4-methylcoumarin |
fluorimetric |
A1086 |
| N-Acetyl-Asp-Gln-Met-Asp-7-amido-4-trifluoromethylcoumarin |
fluorimetric |
A5595 |
| Chromofluor 96 |
fluorimetric |
CF96-101 |
| DFF45/ICAD human |
natural |
D3815 |
| Antibodies |
|
|
| Anti-Caspase 3 from rabbit |
|
C9598 |
| Caspase 4 |
|
back to top |
| Product Name |
Detection |
Product # |
| Enzyme |
|
|
| Caspase 4 human |
|
C6357 |
| Substrates |
|
|
| N-Acetyl-Tyr-Val-Ala-Asp p-nitroanilide |
colorimetric |
A3831 |
| N-Acetyl-Leu-Glu-Val-Asp-7-amido-4-trifluoromethylcoumarin |
fluorimetric |
A2099 |
| N-Acetyl-Tyr-Val-Ala-Asp-7-amido-4-methylcoumarin |
fluorimetric |
A2452 |
| N-Acetyl-Tyr-Val-Ala-Asp-7-amido-4-trifluoromethylcoumarin |
fluorimetric |
A9965 |
| Antibodies |
|
|
| Anti-Caspase 4 from rabbit |
|
C4481 |
| Monoclonal Anti-Caspase 4 from mouse |
|
C3392 |
| Caspase 5 |
|
back to top |
| Product Name |
Detection |
Product # |
| Enzyme |
|
|
| Caspase 5 human |
|
C6482 |
| Inhibitor |
|
|
| N-Acetyl-Trp-Glu-His-Asp-al |
|
A1466 |
| Substrates |
|
|
| N-Acetyl-Trp-Glu-His-Asp-p-nitroanilide |
colorimetric |
A6845 |
| N-Acetyl-Trp-Glu-His-Asp-7-amide-4-trifluoromethylcoumarin |
fluorimetric |
A6720 |
| Antibodies |
|
|
| Monoclonal Anti-Caspase 5 from mouse |
|
C6979 |
| Caspase 6 |
|
back to top |
| Product Name |
Detection |
Product # |
| Enzyme |
|
|
| Caspase 6 human |
|
C4977 |
| Inhibitors |
|
|
| N-Acetyl-Val-Glu-Ile-Asp-al |
|
A6339 |
| Biotin-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethyl ketone |
|
B1807 |
| Z-Asp(OMe)-Gln-Met-Asp(OMe) fluoromethyl ketone |
|
C0480 |
| Z-Val-Glu(O-Me)-Ile-Asp(O-Me) fluoromethyl ketone |
|
C1730 |
| Substrates |
|
|
| N-Acetyl-Val-Glu-Ile-Asp-p-nitroanilide |
colorimetric |
A5220 |
| N-Acetyl-Val-Glu-Ile-Asp-7-amido-4-methylcoumarin |
fluorimetric |
A0341 |
| N-Acetyl-Val-Glu-His-Asp-7-amido-4-trifluoromethylcoumarin trifluoroacetate salt |
fluorimetric |
A2097 |
| N-Acetyl-Val-Glu-Ile-Asp-7-amido-4-trifluoromethylcoumarin |
fluorimetric |
A5095 |
| Caspase 6 Assay Kit, Fluorimetric |
fluorimetric |
CASP-6-F |
| Antibodies |
|
|
| Anti-Caspase 6 from rabbit |
|
C7599 |
| Caspase 7 |
|
back to top |
| Product Name |
Detection |
Product # |
| Enzyme |
|
|
| Caspase 7 human |
|
C2979 |
| Inhibitors |
|
|
| Arachidic anhydride |
|
A2581 |
| Biotin-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethyl ketone |
|
B1807 |
| Z-Asp(O-Me)-Glu(O-Me)-Val-Asp(O-Me) fluoromethyl ketone |
|
C0605 |
| Substrates |
|
|
| N-Acetyl-Asp-Glu-Val-Asp p-nitroanilide |
colorimetric |
A2559 |
| N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-trifluoromethylcoumarin |
fluorimetric |
A0466 |
| Acetyl-Asp-Glu-Val-Asp-7-amido-4-methylcoumarin |
fluorimetric |
A1086 |
| Antibodies |
|
|
| Monoclonal Anti-Caspase 7 from rat |
|
C1104 |
| Anti-Caspase 7 from rabbit |
|
C7724 |
| Caspase 8 |
|
back to top |
| Product Name |
Detection |
Product # |
| Enzyme |
|
|
| Caspase 8 human |
|
C1099 |
| Inhibitors |
|
|
| N-Acetyl-Ile-Glu-Thr-Asp-al |
|
A1216 |
| Biotin-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethyl ketone |
|
B1807 |
| Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone |
|
C1230 |
| Z-Leu-Glu(OMe)-Thr-Asp(OMe)-fluoromethyl ketone |
|
C8734 |
| Substrates |
|
|
| N-Acetyl-Ile-Glu-Thr-Asp-p-nitroanilide |
colorimetric |
A9968 |
| Caspase 8 Assay Kit, Colorimetric |
colorimetric |
CASP-8-C |
| N-Acetyl-Ala-Glu-Val-Asp-7-amido-4-trifluoromethylcoumarin |
fluorimetric |
A0973 |
| N-Acetyl-Ile-Glu-Thr-Asp-7-Amido-4-methylcoumarin |
fluorimetric |
A4188 |
| N-Acetyl-Leu-Glu-Thr-Asp-7-Amido-4-trifluoromethylcoumarin |
fluorimetric |
A6095 |
| Z-Ile-Glu-Thr-Asp 7-amido-4-trifluoromethylcoumarin |
fluorimetric |
C5599 |
| Caspase 8 Assay Kit, Fluorimetric |
fluorimetric |
CASP-8-F |
| Antibodies |
|
|
| Monoclonal Anti-Caspase 8 from mouse |
|
C4106 |
| Anti-Caspase 8 (GD-13) from rabbit |
|
C2976 |
| Anti-Caspase 8 (SK-16) from rabbit |
|
C3101 |
| Anti-pro-Caspase 8 from rabbit |
|
C7849 |
| Caspase 9 |
|
back to top |
| Product Name |
Detection |
Product # |
| Enzyme |
|
|
| Caspase 9 human |
|
C8726 |
| Inhibitor |
|
|
| Z-Leu-Glu(O-ME)-His-Asp(O-Me) fluoromethyl ketone |
|
C1355 |
| Substrates |
|
|
| N-Acetyl-Leu-Glu-His-Asp-p-nitroaniline |
colorimetric |
A5970 |
| N-Acetyl-Val-Glu-His-Asp-7-amido-4-trifluoromethylcoumarin trifluoroacetate salt |
fluorimetric |
A2097 |
| N-Acetyl-Leu-Glu-His-Asp-7-amido-4-trifluoromethylcoumarin |
fluorimetric |
A5845 |
| Antibodies |
|
|
| Monoclonal Anti-Caspase 9 from mouse |
|
C4356 |
| Anti-Caspase 9 from rabbit |
|
C7729 |
| Anti-Caspase 9 from rabbit |
|
C9235 |
| Caspase 10 |
|
back to top |
| Product Name |
Detection |
Product # |
| Enzyme |
|
|
| Caspase 10 human |
|
C6607 |
| Inhibitors |
|
|
| Biotin-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethyl ketone |
|
B1807 |
| Z-Leu-Glu(OMe)-Glu(OMe)-Asp(OMe)-fluoromethyl ketone |
|
C8859 |
| Antibodies |
|
|
| Monoclonal Anti-Caspase 10 from rat |
|
C1229 |
| Anti-Caspase 10 from rabbit |
|
C8351 |
| Monoclonal Anti-Caspase 11 from rat |
|
C1354 |
| Monoclonal Anti-Caspase 12 from rat |
|
C7611 |
| Anti-Caspase 13 (ERICE) from rabbit |
|
C8854 |
| Cathepsin B |
|
back to top |
| Product Name |
Detection |
Product # |
| Enzyme |
|
|
| Cathepsin B from bovine spleen |
|
C6286 |
| Cathepsin B from human liver |
|
C8571 |
| Inhibitors |
|
|
| Calpain Inhibitor II |
|
A6060 |
| Calpain Inhibitor I |
|
A6185 |
| Antipain hydrochloride |
|
A6191 |
| Biotin-Phe-Ala-fluoromethyl ketone |
|
B1932 |
| Cystatin from chicken egg white |
|
C0408 |
| CA-074 |
|
C5732 |
| CA-074 methyl ester |
|
C5857 |
| Chymostatin |
|
C7268 |
| Cystatin from chicken egg white |
|
C8917 |
| Z-Leu-Leu-Leu-fluoromethyl ketone |
|
C8984 |
| Z-Phe-Phe-fluoromethyl ketone |
|
C9109 |
| E-64 |
|
E3132 |
| Leupeptin trifluoroacetate salt |
|
L2023 |
| N-Methoxysuccinyl-Phe-HOMO-Phe-fluoromethyl ketone |
|
M5314 |
| a2-Macroglobulin from human plasma |
|
M6159 |
| Procathepsin B Fragment 26-50, rat |
|
P0350 |
| Procathepsin B Fragment 36-50, rat |
|
P0475 |
| Substrates |
|
|
| Na-Benzoyl-L-arginine 4-methoxy-b-naphthylamide hydrochloride |
fluorimetric |
B0885 |
| Z-Val-Lys-Lys-Arg-4-methoxy-b-naphthylamide trihydrochloride |
fluorimetric |
C2772 |
| Z-Phe-Arg 4-methoxy-b-naphthylamide hydrochloride |
fluorimetric |
C3282 |
| Z-Arg-Arg-7-amido-4-Z-RR-AMC-methylcoumarin hydrochloride |
fluorimetric |
C5429 |
| Z-Arg-Arg 4-methoxy-b-naphthylamide acetate salt |
fluorimetric |
C5520 |
| Z-Ala-Arg-Arg 4-methoxy-b-naphthylamide acetate salt |
fluorimetric |
C8536 |
| N-Succinyl-Leu-Leu-Val-Tyr-7-Amido-4-Methylcoumarin |
fluorimetric |
S6510 |
| Hippuryl-Arg |
Non-chromogenic |
H2508 |
| Cathepsin C |
|
back to top |
| Product Name |
Detection |
Product # |
| Enzyme |
|
|
| Cathepsin C from bovine spleen |
|
C8511 |
| Substrates |
|
|
| Gly-Phe p-nitroanilide |
colorimetric |
G0142 |
| Gly-Phe b-naphthylamide |
fluorimetric |
G4255 |
| Gly-Phe b-naphthylamide |
fluorimetric |
G9512 |
| Ser-Tyr b-naphthylamide |
fluorimetric |
S5628 |
| Cathepsin D |
|
back to top |
| Product Name |
Detection |
Product # |
| Enzymes |
|
|
| Cathepsin D from bovine spleen |
|
C3138 |
| Cathepsin D from human liver |
|
C8696 |
| Inhibitors |
|
|
| Antipain hydrochloride |
|
A6191 |
| Chymostatin |
|
C7268 |
| Pepstatin A |
|
P5318 |
| Substrates |
|
|
| Boc-Phe-Ala-Ala-p-Nitro-Phe-Phe-Val-Leu 4-hydroxymethylpyridine ester |
colorimetric |
B1644 |
| N-Acetyl-Arg-Gly-Phe-Phe-Pro-7-amido-4-methylcoumarin |
fluorimetric |
C6358 |
| N-Acetyl-Arg-Gly-Phe-Phe-Pro-7-amido-4-trifluoromethylcoumarin |
fluorimetric |
C6983 |
| N-Acetyl-Arg-Gly-Phe-Phe-Pro 4-methoxy-2-naphthylamide |
fluorimetric |
C7108 |
| 7-Methoxycoumarin-4-Acetyl-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys(DNP)-D-Arg-amide |
fluorimetric |
M0938 |
| Antibodies |
|
|
| Monoclonal Anti-Cathepsin D from mouse |
|
C0715 |
| Cathepsin E |
|
back to top |
| Product Name |
Detection |
Product # |
| Substrate |
|
|
| 7-Methoxycoumarin-4-Acetyl-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys(DNP)-D-Arg-amide |
fluorimetric |
M0938 |
| Cathepsin G |
|
back to top |
| Product Name |
Detection |
Product # |
| Enzyme |
|
|
| Cathepsin G from human leukocytes |
|
C4428 |
| Inhibitors |
|
|
| a1-Antichymotrypsin from human plasma |
|
A9285 |
| Chymostatin |
|
C7268 |
| Z-Gly-Leu-Phe-chloromethyl ketone |
|
C9984 |
| Diisopropyl fluorophosphate |
|
D0879 |
| 3,4-Dichloroisocoumarin |
|
D7910 |
| N-Acetyl-eglin C |
|
E7888 |
| Substrates |
|
|
| N-Methoxysuccinyl-Ala-Ala-Pro-Met p-nitroanilide |
colorimetric |
M7771 |
| N-Succinyl-Ala-Ala-Pro-Phe p-nitroanilide |
colorimetric |
S7388 |
| N-Succinyl-Gly-Gly-Phe-7-amido-4-trifluoromethylcoumarin |
fluorimetric |
S4689 |
| N-Succinyl-Gly-Gly-Phe-4-methoxy-2-naphthylamide |
fluorimetric |
S4814 |
| N-Succinyl-Ala-Ala-Pro-Phe thiobenzyl ester |
fluorimetric |
S6518 |
| N-Succinyl-Phe-Leu-Phe thiobenzyl ester |
fluorimetric |
S6643 |
| Cathepsin L |
|
back to top |
| Product Name |
Detection |
Product # |
| Enzyme |
|
|
| Cathepsin L from human liver |
|
C6854 |
| Inhibitors |
|
|
| Calpain Inhibitor I |
|
A6185 |
| Z-Leu-Leu-Leu-fluoromethyl ketone |
|
C8984 |
| Z-Phe-Phe-fluoromethyl ketone |
|
C9109 |
| Z-Leu-Leu-Tyr-fluoromethyl ketone |
|
C9234 |
| Z-Leu-Leu-Tyr-CHN2 |
|
C9859 |
| N-Methoxysuccinyl-Phe-HOMO-Phe-fluoromethyl ketone |
|
M5314 |
| Substrates |
|
|
| Z-Phe-Arg 4-methoxy-b-naphthylamide hydrochloride |
fluorimetric |
C3282 |
| N-Succinyl-Ala-Ala-Pro-Phe p-nitroanilide |
colorimetric |
S7388 |
| Antibodies |
|
|
| Monoclonal Anti-Cathepsin D from mouse |
|
C0715 |
| Granzyme A |
|
