Elafin

Calculated Molecular Masses     Average Molecular Mass: 5999.20 Da     Monoisotopic Molecular Mass: 5994.8158 Da Isoelectric Point (pI): 9.7

Elafin Peptide Sequence1

Elafin is a peptide found in the human epithelia. It is a reversible, tightly binding inhibitor of human leukocyte elastase and proteinase found in human epithelia 3.

K_i = 1.7 x 10^-10 M for human leukocyte elastase²
K_i = 4.2 x 10^-10 M for human proteinase 3³

Elafin is produced in human skin, lungs, and mammary glands. It may affect the inflammation process and protect cells against destruction by the immune system. Elafin has shown potential applications for the treatment of cardiac infarction and organ rejection, as well as for treatment of seriously injured tissues and inflammatory lung diseases.⁴

Preparation Instructions
Stock solutions of Elafin may be prepared in water. Subsequent dilutions should be made into aqueous buffers, pH 4.0-8.0.

Storage/Stability
This product ships at ambient temperature and storage at 0 to -20°C is recommended. Stock solutions should be stored at -20°C. Avoid repeated freezing and thawing.

References

1. Wiedow, O., et. al., J. Biol. Chem., 266, 3356 (1991)
2. Ying, Q.L., et. al., Biochemistry, 32, 1866 (1991)
3. Ying, Q.L., et. al., J. Respir. Cell. Mol. Biol., 24, 83 (2001)
4. Sallenave, J.M., Respir. Res., 1, 87-92 (2000)

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