Molecular Parameters of Purified Human Plasma Proteins

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Molecular Parameters of Purified Human Plasma Proteins
	Enzyme Explorer

Prealbumin, thyroxine-binding
Retinol-binding protein
Albumin
α-Globulins
β-Globulins
Apolipoproteins
γ-Mobility (non-immunoglobulin)
Complement Components
Coagulation Proteins
Cell-Related Plasma Proteins
Immunoglobulins (Antibodies)
Amyloid Proteins (Non-Immunoglobulin)
Misc. Trace Components

Plasma & Blood Protein Resource

Prealbumin, thyroxine-binding
Protein	Species	Subunit Structure	Method	Chain Length	Protein MW	Amino Terminus	Carb. Content (%)
Prealbumin, thyroxine-binding	Human	Noncovalent tetramer of identical chains	AA	127	54,980	Gly	0
Retinol-binding protein						back to top
Protein	Species	Subunit Structure	Method	Chain Length	Protein MW	Amino Terminus	Carb. Content (%)
Retinol-binding protein	Human	Single chain	AA	182	20,957	Glu	0
Albumin						back to top
Protein	Species	Subunit Structure	Method	Chain Length	Protein MW	Amino Terminus	Carb. Content (%)
Albumin	Human	Single chain	AA	585	66,458	Asp	0
		Nucleic acid precursor	NA	609	69,365		0
	Bovine	Single chain	AA	582	66,210	Asp	0
		Nucleic acid precursor	NA	606
	Porcine	Single chain	AA	~575	~66,300	Asp	0
	Ovine	Single chain	AA	575	~66,300	Asp	0
	Chicken	Single chain	AA	575	~66,300	Asp	0
	Rat	Single chain	AA	584	64,600	Glu	0
		Nucleic acid precursor	NA	608		Glu
α-Globulins						back to top
Protein	Species	Subunit Structure	Method	Chain Length	Protein MW	Amino Terminus	Carb. Content (%)
α-Globulins
α₁-Microglobulin	Human	Single chain	AA	167	26,000	Gly	20
α₁-Acid glycoprotein	Human	Single chain	AA	181	40,000	pGlu	42
	Rat	Nucleic acid precursor	NA	187	~40,000	Gln	+
α₁-Antitrypsin	Human	Single chain	AA	394	54,000	Glu	13
		Nucleic acid precursor	NA
	Baboon	Nucleic acid precursor	NA	394	~54,000	Glu	+
α₁-Antichymortrypsin	Human	Single chain	AA	~440	68,000	Asn	26
			NA	408
α₂-Antiplasmin	Human	Single chain	AA		65,000	Asn	11
α₁-Fetoprotein	Human	Nucleic acid precursor	NA	590	66,300	Thr	3
	Rat	Nucleic acid precursor	NA
	Mouse	Nucleic acid precursor	NA	586	72,000	Ala
9.5 S α₁-Glycoprotein (serum amyloid P component)	Human	Two pentagons (10 non-covalently bound identical subunits)	AA	(182)₁₀	~250,000	His	13
α₁B-Glycoprotein	Human	Possibly a single chain	AA	~480	68,000	Ala	13
α₁T-Glycoprotein	Human	Single chain		~776	85,000		15
Vitamin D-binding protein (Gc globulin)	Human	Single chain	AA	~450	52,000	Leu	4
Thyroxine-binding protein	Human	Single chain			54,000		20
Inter-α-trypsin inhibitor	Human	Single chain	AA		~160,000	Lys	8
Ceruloplasmin	Human	Single chain (easily cleaved)	AA	1,046	132,000	Lys	7
3.8 S Histidine-rich α₂-glycoprotein	Human	Single chain	AA	~440	~58,500	Val	11
Galactoglycoprotein	Human	Single chain	AA	~213	81,000	Blocked	76
3.1 S Leucine-rich α₂-glycoprotein	Human	Single chaine	AA	312	50,000	Val	23
α₂µ-Globulin	Rat (male)	Nucleic acid precursor	NA	162	18,709	Glu	+
Zn-α₂-Glycoprotein	Human	Single chain		~258	41,000		18
α₂HS-Glycoprotein	Human	Two chains (A & B)	AA	~359	49,000	Ala	14
		B chain	AA	27	3,386	Thr	+
α₂-macroglobulin	Human	4 identical subunits	AA	1,450	725,000	Ser	9.4
4S-α₂,β₁-Glycoprotein	Human	Single chain		~465	60,000	Arg	28
Haptoglobin	Human	2 pairs of nonidentical chains (αβ)₂	AA	656	86,018	Val/Ile	16.4
		Single-chain precursor	NA	245
		α¹ chain	AA	83	9,189	Val	0
		α² chain	AA	142	15,939	Val	0
		β chain	AA	245	33,820	Ile	19.4
		β chain	NA
	Canine	One pair of chains (αβ) β chain	AA
Corticosteroid-binding globulin	Human	Single chain			52,000		30
8 S α₃-Glycoprotein	Human	Tetramer			220,000		31
β-Globulins						back to top
Protein	Species	Subunit Structure	Method	Chain Length	Protein MW	Amino Terminus	Carb. Content (%)
Pregnancy-specific β₁-glycoprotein Human	A trimeric aggregate			(42,300)_n		32.6
Transferrin	Human	Single chain	AA	678	79,550	Val	5.9
			NA	679		Val
Ovotransferrin	Chicken	Single chain	AA	686	77,770	Ala	+
		Nucleic acid precursor	NA	686
Hemopexin	Human	Single chain	AA	439	60,000	Thr	22
	Rabbit	Single chain	AA	~440	57,000	Val	20
β₂-Microglobulin	Human	Single chain	AA	99	11,731	Ile	0
	Mouse	Single chain	AA	99		Ile	0
	Rabbit	Single chain	AA	99		Val	0
	Guinea pig	Single chain	AA	99		Val	0
C-Reactive protein	Human	Subunits aggregate as cyclic pentamers	AA	187	(20,946)₅	pGlu	0
	Rabbit	Pentagonal structure	AA	186		Ala	0
β₂-Glycoprotein I	Human	Single chain	AA	326	~50,000	Gly	19
β₂-Glycoprotein III	Human	Single chain, forms complex	AA		35,000		10
Apolipoproteins						back to top
Protein	Species	Subunit Structure	Method	Chain Length	Protein MW	Amino Terminus	Carb. Content (%)
Apolipoprotein A-I (HDL)	Human	Single chain; no disulfides	AA	243	28,076	Asp	0
Apolipoprotein A-II (HDL)	Human	Dimer of 2 identical chains, joined by disulfide	AA	77	17,414	pGlu	0
Apolipoprotein C-I (VLDL)	Human	Single chain; no disulfides	AA	57	6,631	Thr	0
Apolipoprotein C-II	Human	Single chain; no disulfides	AA	78	8,829	Thr	0
Apolipoprotein C-III (VLDL)	Human	Single chain glycopeptide	AA	79	8,764	Ser	3
Apolipoprotein E	Human	Single chain	AA	299	34,183	Lys	+
γ-Mobility (non-immunoglobulin)						back to top
Protein	Species	Subunit Structure	Method	Chain Length	Protein MW	Amino Terminus	Carb. Content (%)
0.6 S γ₂-Globulin	Human	Single chain	AA	47	5,100	Phe	0
2 S γ₂-Globulin	Human	Single chain	AA	132	14,000	Tyr	0
Basic Protein B2	Human	Single chain	AA	~85	9,000		0
Post-γ-Globulin (γ-trace)	Human	Single chain	AA	120	13,248	Ser	0
Complement Components						back to top
Protein	Species	Subunit Structure	Method	Chain Length	Protein MW	Amino Terminus	Carb. Content (%)
C1q	Human	Six identical nocovalently-linked subunits, each with three similar chains (A,B&C) Total of 18 chains	AA		410,000	Glu/Asn	9
		B chain	AA	226		Glu	+
		C chain	AA	~200		Asn	+
C1r	Human	Noncovalent dimer			(83,000)₂		9.4
C1r	Human	B chain	AA	242	27,096	Ile	12.4
C1s	Human	Single chain	AA		83,000	Glu	7.1
C1s	Human	Two chains (a and b)	AA		83,000	Glu/Ile	7.1
C2	Human	Single chain	AA		102,000	Ala	+
C3	Human	Two disulfide-bonded chains	AA	~1,630	~185,000		2
		α chain	AA	~960	115,000	Ser
		β chain	AA	~670	75,000	Ser
	Mouse	ProcC3 is a single-chain precursor	NA		~190,000	Ile
C3a	Human	Fragment of C3 a chain	AA	77	9,093	Ser	0
	Porcine	Fragment of C3 α chain	AA	77	~9,000	Ser
	Rat	Fragment of C3 α chain	AA	78	~9,000	Ser
	Mouse	Fragment of C3 α chain	NA	78	~9,800	Ser
C4	Human	Three disulfide-bonded chains	AA			7
		α chain	AA	~785	93,000
		β chain	AA	~660	75,000
		γ chain	AA	~250	33,000
C4a	Human	Fragment of a chain	AA	77	8,763	Asn	0
	Bovine	Fragment of a chain	AA	77
C5	Human	Two disulfide-bonded chains			185,000		1.6
		α chain	AA	~960	115,000	Thr
		β chain		~670	75,000
C5a	Human	Fragment of α chain	AA	74	8,274	Thr	+
C6	Human	Single chain	AA	~900	1,048,000	Ala	3.8
C7	Human	Single chain	AA	~800	92,400	Ser	6.4
C8	Human	Two noncovalently-linked subunits			163,000
C4-Binding Protein	Human	Disulfide-bonded subunits (Mr 75,000)			540,000	Asn
Factor D (C3 Proactivator Convertase)	Human	Single chain	AA		24,000	Ile	+
Factor B (C3 Proactivator)	Human	Single chain	AA		90,000	Thr	6
		Bb Fragment	AA	505	60,000	Lys	+
Properdin	Human	Four non-covalent identical chains	AA	~480	220,000	Asp	10
Factor H (β₁H)	Human	Single chain	AA	~1,275	155,000	Glu	9.3
C3b-Inactivator	Human	Two disulfide-bonded chains			90,000	Ile/Lys	11
		Light chain	AA		40,000	Ile/Lys	+
		Heavy chain	AA		50,000	Lys	+
Coagulation Proteins						back to top
Protein	Species	Subunit Structure	Method	Chain Length	Protein MW	Amino Terminus	Carb. Content (%)
Prothrombin	Human	Single chain	AA	581	72,000	Ala	12
	Bovine	Single chain	AA	582	72,000	Ala	12
Thrombin	Bovine	Two disulfide-linked chains	AA	~340	37,000	Thre/ILE
		A chain	AA	49	5,728	Thre/ILE	0
		B chain	AA	259	31,000	Ile
FactorVII	Human	Single chain (two chains when activated)	AA		48,000	Ala	16
Factor VIII	Human	Noncovalent complex			(100,000)n		6
Factor IX	Human	Single chain Precursor	NA	462	51,801		+
	Bovine	Single chain	AA	427	~55,000	Tyr	26
Factor IXa (activated)	Human	Heavy and light chains	NA	381
		Light chain	NA	145		Tyr
		Heavy chain	AA	236		Val
	Bovine	Heavy and light chains	AA	390	~46,500	Tyr/Val	11
		Light chain	AA	146	16,600	Tyr	7.4
		Heavy chain	AA	232	27,300	Val	13
Factor X	Human	Heavy and light chains	AA		59,000	Ala/Ser	15
		Light chain	AA	139	16,211	Ala/Ser	0
	Bovine	Heavy and light chains	AA	447	55,000	Trp/Ala	10
		Light chain	AA	140	16,143	Ala/Ser	0
		Heavy chain	AA	307	38,000	Trp/Ala	11.5
Factor Xa Activated	Bovine	Heavy and light chains	AA	396	44,000	Ile/Ala	3
		Light chain	AA	140	16,000	Ala	0
		Heavy chain	AA	256	28,000	Ile	0
Factor XI	Human	Two idenical disulfide-linked chains	AA		130,000	Gly	5
Protein C	Bovine	Two disulfide-linked chains	AA	415	55,000	Ala/Asp	14
		Light chain	AA	155	21,000	Ala	+
		Heavy chain	AA