Fluorous Learning Center

In addition to the extensive line of products, Sigma-Aldrich® and Fluorous Technologies, Inc. have prepared an array of tools to help you successfully implement fluorous techniques in your research. These tools include detailed application notes, a fluorous Cheminar™, ChemFiles, presentations, and literature references.

Application Notes (PDF)

Tags / Protecting Groups

• Tagging with F-Boc-ON: fluorous analogue of the Boc-ON acid-labile N-protecting group/tag (37 Kb PDF)
• FluoMar: solution-phase Marshall resin equivalent™ (167 Kb PDF)
• F-PMB-OH: fluorous propyl methoxy benzyl alcohol for tagging (80 Kb PDF)
• F-Cbz-OSu: fluorous benzyloxycarbonyloxy succinimide analogue; acid-labile N-protecting group/tag (35 Kb PDF)
• Using fluorous thiol as a tag (35 Kb PDF)
• Tagging with fluorous diisopropylsilane (TIPS analog) (37 Kb PDF)

Tags / Protecting Groups Products

Description	FTI Product No.	S-A Product No.
F-Boc-ON	F017003	55118
FluorMar	F017027	40829
F-PMB-OH	F017006	97071
F-Cbz-Osu	F017008	14944
F-Thiol	F017023	08686
F-TIPS analog	F017004	04537

Solution-phase Scavengers

• Nucleophile scavenging with fluorous isatoic anhydride (171 Kb PDF)
• Nucleophile scavenging with fluorous isocyanate (175 Kb PDF)
• Electrophile scavenging with fluorous thiol (42 Kb PDF)

Solution-phase Scavengers Products

Description	FTI Product No.	S-A Product No.
F-Isatoic Anhydride	F017028	07172
F-Isocyanate	F017032	18486
F-Thiol	F017023	08686

Reagents and Catalysts

• Fluorous Mitsunobu strategy for facile separation of byproducts (63 Kb PDF)
• F-PPh3: Using fluorous triphenylphosphine (170 Kb PDF)
• Using the fluorous CDMT coupling reagent (146 Kb PDF)
• Using fluorous thiol to deprotect 2-nitrobenzenesulfonamides (188 Kb PDF)
• F-Sn=O: Selective sulfonylation of 1,2-diols using tin oxide as a catalyst (160 Kb PDF)

Reagents and Catalysts Products

Description	FTI Product No.	S-A Product No.
Mitsunobu reaction	F002610	68333
F-PPh3	F017039	07026
F-CDMT	F026171	672378
F-Thiol	F017023	08686
F-Sn=O	F026051	43482

F-SPE Cartridges

• F-SPE Cartridges and Frequently Asked Questions on F-SPE (64 Kb PDF)
• Fluorous Separation Media

F-SPE Cartridges Products

Description	FTI Product No.	S-A Product No.
2 grams, 8 cc tube, 40 µm particle size	801-0027S	14196
5 grams, 10 cc tube, 40 µm particle size	801-0058S	00866
10 grams, 60 cc tube, 40 µm particle size	801-0109S	08967
20 grams, 60 cc tube, 40 µm particle size	801-0209S	08966, 06961

Presentations

• Fluorous 2007 Overview (1.34 Mb PDF)
• Fluorous Peptide Chemistry (725 b PDF)
• Fluorous Small Molecule Chemistry (641 Kb PDF)
• Fluorous Immobilization for Microarray Formation (1.29 Mb PDF)

For additional Fluorous Technologies, Inc. presentations, click here.

References

• Fluorous Protecting Groups and Tags
• Fluorous Catalysts and Ligands

Download the Endnote database containing Fluorous References (more than 2,500 references). Please note that you’ll need a version of Endnote (.enl) to use this database.

Cheminar and ChemFiles

• Fluorous Cheminar™ — "Fluorous Chemistry for Synthesis, Separation and Enrichment"
• Fluorous Synthesis and Separation ChemFile (1.07 Mb PDF)
• Fluorous Peptide Synthesis ChemFile (1.25 Mb PDF)
• Fluorous Protection ChemFile (1.02 Mb PDF)

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