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The separation of fluorous compounds from non-fluorous compounds using fluorous silica gel is the central theme of fluorous techniques. Fluorous solid phase extraction (F-SPE) is used for quick separations of reaction mixtures involving FluoroFlash® tags, scavengers, and reagents. The separation of fluorous compounds by F-SPE is a reliable and generic procedure that more greatly resembles filtration than chromatography. The facile separation depends primarily on the presence or absence of a light fluorous tag, not polarity or other molecular features that control traditional chromatography.
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Fluorous Solid Phase Extraction Dye Demonstration
A visual representation of the FluoroFlash® solid phase extraction technique illustrates the easy separation of a fluorous-tagged product from the non-fluorous compounds through the use of colored dyes.
A mixture of a non-fluorous dye and a fluorous dye is loaded onto the F-SPE cartridge.
Non-fluorous dye is washed off with a fluorophobic solvent wash, 80:20 MeOH:water (middle test tube).
Fluorous dye is washed off with a fluorophilic solvent wash, MeOH (right test tube).
For detailed F-SPE Application Notes, please visit our Learning Center. |
Fluorous Solid Phase Extractions are marked by:
- High selectivity
- Simple binary separation
- Large loading capacity
- No fluorous solvents used
- Recyclable up to 10 times
- Automation compatible
| Description |
Size |
Product # |
| FluoroFlash® SPE cartridges, 2 g, 8 cc tube |
Pack of 20 |
14196 |
| FluoroFlash® SPE cartridges, 5 g, 10 cc tube |
Pack of 10 |
00866 |
| FluoroFlash® SPE cartridges, 10 g, 60 cc tube |
Pack of 5 |
08967 |
| FluoroFlash® SPE cartridges, 20 g, 60 cc tube |
Pack of 2 |
08966 |
| FluoroFlash® SPE cartridges, 20 g, 60 cc tube |
Pack of 5 |
06961 |
| FluoroFlash® Silica Gel, 40 micron particle size |
100 g |
08965 |
| FluoroFlash® TLC Plates with F254 indicator |
Pack of 10 |
16888 |
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