Vol. 3, No. 3 Reagents for Suzuki Coupling Download PDF
Introduction / Boronic acids / Boronic acid Esters / Diboron Esters / Potassium Trifluoroborates Pd-Catalysts with Perfluoroalkyl Ponytails / OSVB, Volume 3: Suzuki Coupling

Potassium Trifluoroborates

Alkyl, aryl, and alkenyl trifluoroborate salts are compelling alternatives to boronic acids in Suzuki coupling and in rhodium catalyzed carbon-carbon bond forming reactions. These salts are air and water stable, and in many cases eliminate the need to add either additional ligands or base for cross coupling. Whereas the boronic acids readily form cyclic anhydrides, these new salts do not form unwanted side products. In many cases, the trifluoroborate salt is more efficient and tolerant to functional groups than the corresponding boronic acids.

Potassium 3-thiophenetrifluoroborate			Potassium 4-bromophenyltrifluoro-borate
57,157-1	C4H3BF3KS	1g; 5g	57,154-7	C6H4BBrF3K	1g; 5g
Potassium 2-bromophenyltrifluoro-borate			Potassium 3-nitrophenyltrifluoro-borate
57,610-7	C6H4BBrF3K	1g; 5g	57,159-8	C6H4BF3KNO2	1g; 5g
Potassium phenyltrifluoroborate			Potassium 4-(trifluoromethyl)phenyltri-fluoroborate
56,395-1	C6H5BF3K	1g; 5g	57,613-1	C7H4BF6K	1g; 5g
Potassium 4-formylphenyltrifluoro-borate			Potassium benzyltrifluoroborate
57,609-3	C7H5BF3KO	1g; 5g	56,305-6	C7H7BF3K	1g; 5g
Potassium o-tolyltrifluoroborate			Potassium p-tolyltrifluoroborate
57,612-3	C7H7BF3K	1g; 5g	57,155-5	C7H7BF3K	1g; 5g
Potassium 3-methoxyphenyltri-fluoroborate			Potassium 3,5-bis(trifluoromethyl)-phenyltrifluoroborate
57,611-5	C7H7BF3KO	1g; 5g	57,156-3	C8H3BF9K	1g; 5g
Potassium trans-styryltrifluoroborate			Potassium phenethyltrifluoroborate
57,615-8	C8H7BF3K	1g; 5g	56,309-9	C8H7BF3K	1g; 5g