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Theme: "Carbon-Carbon Bond Formation"

   

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NEW LITERATURE

Vol. 6, No. 7
Multi-Component Reactions

(1.12 MB PDF)

Vol. 6, No. 8
Privileged Ligands

(1.1 MB PDF)
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NEW PRODUCTS
Palladium Catalysts


674702


668532


668923
PEPPSI-SIPr is a novel N-Heterocyclic (NHC)-based catalyst that offers remarkable scope, reactivity, and stability in C-C and C-N bond-forming processes. Very active oxime-palladacycle catalyst for C-C bond-forming reactions ranging from the Suzuki to Ullman-type couplings in aqueous media. Highly robust palladacycle catalyst that has successfully mediated C-C bond-forming processes, ranging from the Heck to the Sonogashira to the Suzuki reaction in moderate to excellent yields.

Phosphines for Cross Coupling


675709


675938
The combination of this P,O-ligand with Pd(dba)2 generates a highly active catalyst system that exhibits broad utility in the Suzuki-Miyaura reaction. Bulky biaryl ligand that has proven highly useful for the unprecedented coupling of aryl chlorides and bromides with allylic alcohols via formal C-O bond formation.



676187



676179

Neopentyl-substituted phosphines form highly active catalysts in conjunction with Pd precursors for the amination of a wide range of amines with aryl halides.  The second ligand shown above has been successfully applied in both cross-coupling and amination reactions under aqueous conditions.


Boron Reagents for Suzuki Coupling



666491



666556



666459



673854



673862



652342



666793



674958



654396



676659



677787



677809


Organotin and Grignard Reagents


675660


673013


675679

Halogenated Substrates for Suzuki Coupling


652636


673994



669326



669350



669369



676063



676039



677736



666416



667366


Scavengers


668583


668605


668591

Other Catalysts

Other Reagents



667080


674613
Acts as an organocatalyst in highly enantioselective intramolecular Stetter reactions. Used in conjunction with CF3I for nucleophilic trifluoromethylation of aldehydes and ketones and chiral N-tolylsulfinimines.


PRODUCT SPOTLIGHTS

Click Chemistry: A "Click" Away from Drug Discovery.


Organotrifluoroborates: Potent Boronic Acid Surrogates.


Benzoylation Reagents: Simple tools for α-oxygenation of aldehydes and ketones.


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