Cross-Coupling

Cross-coupling has been an essential reaction for the past twenty years with its utilization increasing exponentially for the last 10 years. It has been used in the synthesis of a variety of products ranging from natural compounds to polymers. Numerous research groups have developed new metal complexes and ligands, expanding the scope of these transformations to give access to more complex molecules.

Sigma-Aldrich offers an extensive number of resources addressing cross-coupling reactions. ChemFiles highlights our extensive portfolio of heterocyclic substrates, organometallic reagents, and catalysts and ligands used in cross-coupling. Our Web site features technology spotlights and our first-in-the-industry ChemBlogs.

ChemFiles

Vol. 7, No. 10 Cross-Coupling 3.45 Mb PDF	Vol. 7, No. 7 Boron Reagents for Suzuki Coupling 1.56 Mb PDF	Vol. 7, No. 4 Grignard and Organozinc Reagents 868 Kb PDF
Vol. 7, No. 6 Halogenated Heterocycles 2.77 Mb PDF

Technology Spotlights

• Buchwald Ligands
• PEPPSI™-IPr
• Potassium Cyclopropyltrifluoroborate
• ChemDose®
• Organosilanols
• Organotrifluoroborates

ChemBlogs

• Direct Arylation on "Water"
• Conversion of aryl halides to aldehydes using Pd catalysts
• PinP(O)H: An Air-Stable H-Phosphonate for the Efficient, Catalytic Cross-Coupling of Aryl Tosylates with Aryl Grignards
• Buchwald Ligands for Cu-Catalyzed C–N and C–O Arylation

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