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Sigma-Aldrich is pleased to announce an agreement with Materia, Inc. to exclusively distribute research quantities of Grubbs catalysts and Hoveyda–Grubbs catalysts. For a recent review on cross-metathesis of nitrogen-containing systems and for pertinent references to other systems, see Aldrichimica Acta, 2003, 36(3), 93.
Click here to email the Organometallics Product Line Manager.
To order, call 800-558-9160 or fax 800-962-9591.
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Grubbs Catalyst 1st Generation
The first metathesis catalyst to be widely utilized in organic
synthesis, Grubbs First Generation Catalyst effects ring-closing metathesis, olefin cross-metathesis, and ROMP with high activities and tolerance for functional groups and protic media.1,2
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56,974-7
100mg; 500mg; 2g
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Grubbs Catalyst 2nd Generation
Grubbs Second Generation Catalyst is a more active analog of the
first-generation Grubbs catalyst for ring-closing metathesis, cross metathesis, and ROMP,3 and can lead to trisubstituted olefins via cross metathesis;4 it ring-closes olefins with excellent functional group tolerance and selectivity.5
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57,794-4
100mg; 500mg; 2g
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Hoveyda–Grubbs Catalyst 1st Generation
An efficient, recyclable catalyst for RCM of terminal olefins.6,7
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56,975-5
100mg; 500mg; 2g
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Hoveyda–Grubbs Catalyst 2nd Generation
The Hoveyda–Grubbs Second Generation catalyst shows efficiencies
similar to those of second-generation Grubbs catalyst, but with different substrate specificities. The catalyst is unique in catalyzing the ring-closing, ring-opening, and cross-metathesis reactions of highly electron-deficient substrates.7,8
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57,870-3
100mg; 500mg; 2g
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Dichloro(3-methyl-2-butenylidene)bis(tricyclopentylphosphine) ruthenium(II)
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57,868-1
1g; 5g
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Dichloro(3-methyl-2-butenylidene)bis(tricyclohexylphosphine) ruthenium(II) |
(1) Schwab, P. et al. J. Am. Chem. Soc. 1996,
118, 100. (2) Miller, S. J. et al. ibid. 1996, 118,
9606. (3) Trnka, T. M.; Grubbs, R. H. Acc. Chem. Res. 2001,
34, 18. (4) Chatterjee, A. K.; Grubbs, R. H. Org. Lett. 1999,
1, 1751. (5) Scholl, M. et al. ibid. 1999, 1,
953. (b) Saito, N. et al. ibid. 2002, 4 803. (6) Kingsbury, J. S. et al. J. Am. Chem. Soc. 1999, 121, 791. (7) Garber, S. B. et al. ibid 2000, 1223, 8168. (8) Randl, S. et al. Synlett 2001, 3, 430.
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