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Privileged structures are a class of molecules that are capable of binding to multiple receptors with high affinity. In order to be considered privileged, a substructure should represent a molecule’s core element and make up a significant portion of its total mass. Recent reports1,2,3 have shown the presence of the arylpiperazine scaffold in potent and selective agonists of the human melanocortin-4 receptor (Fig 1).
 | | Fig. 1 |
Sigma-Aldrich is proud to offer the following new BOC-protected arylpiperazines to our organic synthesis and drug discovery customers.
| Product Name |
Structure |
Product # |
| 1-BOC-4-(2-formylphenyl)piperazine, 97% |  | 65,151-6 |
| 1-BOC-4-(4-formylphenyl)piperazine, 97% |
 | 65,142-7 |
| 1-BOC-4-(2-methoxycarbonylphenyl)piperazine |  | 65,237-7 |
| 1-BOC-4-(4-methoxycarbonylphenyl)piperazine, 97% |  | 65,238-5 |
| 1-BOC-4-(3-(ethoxycarbonyl)phenyl)piperazine, 97% |  | 65,412-4 |
| 4-BOC-1-(5-bromo-2-pyridyl)piperazine, 97% |
 | 65,376-4 |
| 4-BOC-1-(6-bromo-2-pyridyl)piperazine, 97% |  | 65,377-2 |
| 4-BOC-1-(6-methyl-2-pyridyl)piperazine, 97% |  | 65,375-6 |
| 4-(BOC-piperazin-1-yl)-3-nitrobenzoic acid, 97% |  | 65,192-3 |
| Methyl 2-(BOC-piperazin-1-yl)-5-nitrobenzoate, 97% |  | 65,193-1 |
References:
- Richardson, T. I. et al. J. Med. Chem. 2004, 47, 744.
- Pontillo, J. et al. Bioorg. Med. Chem. Lett. 2004, 14, 4417.
- Dyck, B. et al. Bioorg. Med. Chem. Lett. 2003, 13, 3793.
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