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Functionalized Silica Gels
Sigma-Aldrich and Silicycle Inc. have partnered to offer a wide range of functionalized silica gels for scavenging and organic synthesis. Silicycle Inc. manufactures the novel products to combine with the wide resins that Sigma-Aldrich now offers to help your synthetic needs.
These novel silica gel products offer numerous advantages over the well-known gel-type resins.
Advantages of Functionalized Silica
- Solvent Independent: Silica neither shrinks nor swells in any solvent. Also, since it is end-capped, it will not dissolve in the solvent. Your scavenger will not dictate which solvent you will use with your reaction.
- Easy to use: Easy to weigh and handle since the silica does not carry a static charge and is always free flowing.
- Mechanically Stable: Works well with overhead stirring and can be used with a bottom coupled spin bar for up to four hours.
- Thermally Stable: Silica can withstand temperatures over 200°C and is suitable for use in microwave synthesizers.
- Scalable: Works on microgram to the multi ton scale.
| Silica-Based
Scavengers | | |
| Product Name | Product # | Loading |
| Metal Scavengers | |
| 3-(Ethylenediamino)propyl-functionalized silica gel particle size
200-400 mesh | 53,791-8 | 1.4 mmol/g |
| 3-(Diethylenetriamino)propyl-functionalized silica gel particle size
200-400 mesh | 53,792-6 | 1.3 mmol/g |
| 3-Mercaptopropyl-functionalized silica gel particle size
200-400 mesh | 53,808-6 | 1.2 mmol/g |
| 2-(4-(Ethylenediamino)benzyl)ethyl-functionalized silica gel
| 55,258-5 | 1.2 mmol/g |
| 3-(1-Thioureido)propyl, functionalized silica gel particle size 200-400 | 56,987-9 | 1.1 mmol/g |
| Triamine tetraacetate, silica-supported particle size 200-400 mesh | 57,260-8 | 1.25 mmol/g |
| Triamine tetracetate, sodium salt, silica-supported | 59,415-6 | 0.5-1.0 mmol/g |
| Nucleophilic Scavengers | |
| 3-(Isocyanato)propyl-functionalized silica gel particle size
200-400 mesh | 53,778-0 | 1.2 mmol/g |
| 3-(Thiocyanato)propyl-functionalized silica gel particle size
200-400 mesh | 53,794-2 | 0.8 mmol/g |
| 4-Ethyl benzenesulfonyl chloride-functionalized silica gel particle
size 200-400 mesh | 53,797-7 | 1.0 mmol/g |
| Propionyl chloride-functionalized silica gel | 53,807-8 | 1.0 mmol/g |
| 3-(2-Succinic anhydride)propyl-functionalized silica gel particle size
200-400 mesh | 55,269-0 | 0.7 mmol/g |
| 3-(Maleimido)propyl, functionalized silica gel bead size
200-400 mesh | 56,990-9 | 0.7 mmol/g |
| Electrophilic Scavengers | |
| 3-Aminopropyl-functionalized silica gel mean pore size
60 Å particle size 40-63 µm | 36,425-8 | 1.0 mmol/g |
| 2-(4-Toluenesulfonyl hydrazino)ethyl-functionalized silica gel
| 55,259-3 | 1.0 mmol/g |
| Benzenesulfonylazide, functionalized silica gel particle size
70-100 mesh | 59,027-4 | 0.5 mmol/g |
| Silica-Based
Reagents | | back to
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| Product Name | Product # | Loading |
| Oxidants | |
| Pyridinium chlorochromate bead size 200-400 mm capacity
(silica gel) ~20 %, on silica gel | 56,980-1 | 20% wt/wt |
| Pyridinium dichromate on silica gel particle size
200-400 mesh | 56,982-8 | 20% wt/wt |
| Potassium permanganate on silica gel bead size
200-400 mesh | 56,989-5 | 20% wt/wt |
| Iron(III) nitrate on silica gel | 57,255-1 | 0.3 mmol/g |
| Perruthenate on silica gel | 57,257-8 | 0.3 mmol/g |
| TEMPO on silica gel particle size 120-70 mesh | 57,634-4 | 0.7 mmol/g |
| Trimethylammonium chlorite, functionalized silica gel particle size
70-100 mesh | 58,902-0 | 0.5 mmol/g |
| Bases | |
| 3-(Imidazol-1-yl)propyl-functionalized silica gel particle size
200-400 mesh | 53,795-0 | 1.0 mmol/g |
| 2-(2-Pyridyl)ethyl-functionalized silica gel particle size
200-400 mesh | 53,798-5 | 0.8-1.2 mmol/g |
| 3-(Dimethylamino)propyl-functionalized silica gel particle size
200-400 mesh | 53,804-3 | 1.4 mmol/g |
| 3-(1-Piperazino)propyl-functionalized silica gel particle size
200-400 mesh | 55,260-7 | 0.8 mmol/g |
| 3-(Trimethylammonium)propyl-functionalized silica gel, carbonate
particle size 200-400 mesh | 55,288-7 | 0.8 mmol/g |
| 3-(1-Morpholino)propyl- functionalized silica gel particle size
200-400 mesh | 56,979-8 | 1.1 mmol/g |
| 3-(1-Piperidino)propyl, functionalized silica gel particle size
200-400 mesh | 56,984-4 | 1.1 mmol/g |
| 3-(4,4'-Trimethylenedipiperidino)propyl, functionalized silica gel
bead size 200-400 mesh | 56,985-2 | 1.0 mmol/g |
| 3-(1,3,4,6,7,8,-Hexahydro-2H-pyrimido-[1,2-a]pyrimidino)propyl, functionalized silica gel particle
size 200-400 mesh | 56,986-0 | 1.0 mmol/g |
| Miscellaneous | |
| 2-Diphenylphosphinoethyl-functionalized silica gel particle size
200-400 mesh | 53,801-9 | 0.7 mmol/g |
| Ytterbium(III) benzenesulfonate-functionalized silica gel | 58,903-9 | 0.2 mmol/g |
| 3-(1-Cyclohexylcarbodiimido)propyl, functionalized silica gel bead
size 200-400 mesh | 56,988-7 | 0.9 mmol/g |
| Cyanoborohydride, silica-supported | 59,404-0 | 1.0 mmol/g |
| Aluminum chloride-functionalized silica gel | 63,006-3 | 1.5 mmol/g |
| Silica-Based
Linkers | | back to
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| Product Name | Product # | Loading |
| 4-Ethyl-benzene sulfonamide-functionalized silica gel | 53,793-4 | 0.9 mmol/g |
| Dimethylsiloxy-functionalized silica gel particle size
200-400 mesh | 53,802-7 | 1.5 mmol/g |
| 3-(Ureido)propyl-functionalized silica gel particle size
200-400 mesh | 55,261-5 | 1.2 mmol/g |
| 3-(4-Nitrobenzamido)propyl-functionalized silica gel particle size
200-400 mesh | 55,262-3 | 1.2 mmol/g |
| 4-Benzyl chloride-functionalized silica gel | 55,263-1 | 1.2 mmol/g |
| 4-Bromopropyl-functionalized silica gel particle size
200-400 mesh | 55,265-8 | 1.5 mmol/g |
| 4-Bromophenyl-functionalized silica gel particle size
200-400 mesh | 55,266-6 | 1.0 mmol/g |
| 2-(Carbomethoxy)ethyl-functionalized silica gel | 55,268-2 | 1.6 mmol/g |
| 1-Allyl-functionalized silica gel particle size
200-400 mesh | 55,270-4 | 1.1 mmol/g |
| 4-Carboxybutyl, functionalized silica gel particle size
200-400 mesh | 56,983-6 | 1.6 mmol/g |
| Adsorbent for Reversed-Phase Chromatography | | back to top |
| Product Name | Product # | Loading |
| Non-Polar | |
| Cyclohexyl-functionalized silica gel | 55,271-2 | 10% carbon |
| 2-(1-Adamantyl)ethyl-functionalized silica gel particle size
200-400 mesh | 55,272-0 | 16% carbon |
| Phenyl-functionalized silica gel | 55,349-2 | 9% carbon |
| Octyl-functionalized silica gel | 55,353-0 | 12% carbon |
| Butyl-functionalized silica gel pore size 60 Å particle
size 40-60 µm | 55,354-9 | 8% carbon |
| Polar | |
| 3-(3,4-Cyclohexyldiol)propyl-functionalized silica gel
| 55,274-7 | 1.0 mmol/g |
| 2-Cyano-functionalized silica gel | 55,348-4 | 1.5-2.0 mmol/g |
| Ion Exchange | |
| 2-(4-Benzyltrimethylammonium)ethyl-functionalized silica gel, chloride
particle size 200-400 mesh | 55,286-0 | 1.1 mmol/g |
| 3-(Tributylammonium)propyl-functionalized silica gel chloride salt
| 55,287-9 | 0.5 mmol/g |
| 3-(Trimethylammonium)propyl-functionalized silica gel, chloride | 64,227-4 | 1.2 mmol/g |
| Specialty | |
| 3-(Glycidoxy)propyl-functionalized silica gel particle size
200-400 mesh | 53,796-9 | 1 mmol/g |
| 2-(3,4-Epoxycyclohexyl)ethyl-functionalized silica gel particle size
200-400 mesh | 55,273-9 | 0.8 mmol/g |
Silica Kits | |
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| Product Name | Product # |
| Bases Kit-Functionalized Silica Gels |
57,943-2 |
| Metal Scavengers Kit-Functionalized Silica Gels |
57,897-5 |
| Organic Scavengers Kit-Functionalized Silica Gels |
57,898-3 |
| Oxidant Kit-Functionalized Silica Gels |
57,904-1 |
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