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Solid-supported reagents have been utilized in a variety of ways to facilitate combinatorial synthesis. They are also being used in solution-phase parallel synthesis and multi-step organic synthesis scavengers to ease reaction workup and product purification.1
Scavenger resins are added to the pot after the reaction is completed in order to quench and selectively bind to excess reagents or byproducts. Filtration of the reaction mixture separates the polymer-bound impurities from the product yielding pure compounds. Scavenger resins ease the purification process by providing an alternative to extractions and chromatography. Multiple scavenger resins can be used in parallel; thus, multiple reagents and byproducts and be removed concurrently. The choice of scavenger resin is determined by the functionality of the impurity.
Polymer-Supported Scavengers
Polymer-Supported Reagents
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