LOPAC 1280™: Library of Pharmacologically Active Compounds

Reveal new insights with the predictable activities and proven scaffolds in LOPAC^1280™

The power and convenience of the known actives in Sigma's Library of Pharmacologically Active Compounds is assured.  This annotated collection of small molecule modulators and approved drugs impacts most cellular processes and covers all major drug target classes.

Consider the bioactives you want in your library and reveal why researchers worldwide trust what we have in ours:

• 1,280 pharmacologically active compounds— All major target classes are represented, including GPCRs¹ and kinases,^2,3 making LOPAC^1280™ the most flexible assay validation library available. Use the LOPAC^1280™ Navigator to explore the components.
   
• Marketed drugs and pharmaceutically relevant structures— Predictable activities and proven scaffolds directed against a wide range of drug targets.
   
• Annotated structure/activity database— Convenient management of individual samples, subsets, or the entire collection.
   
• Guaranteed Sigma-Aldrich quality and easy re-supply— Highly pure compounds, each available as an individual catalog item.
   
• Pre-solubilized and normalized compounds— Ready-to use DMSO stocks require less time-consuming sample preparation. Standard concentrations allow easy determination of IC₅₀ values for comparison of activities within and across compound and target classes.

LOPAC^1280™ components are available in the NCBI PubChem database. 

Relevant Compounds and Pharmacological Activities

LOPAC^1280™ includes the latest pharmacological tools developed against all major target classes. LOPAC^1280™ not only offers 1,280 high-purity, bioactive small organic molecules but also gives access to comprehensive electronic support documentation. LOPAC^1280™ compounds are also indexed in the NCBI PubChem database.

Antiproliferatives Enzyme inhibitors Antibiotics Cell cycle regulators Apoptosis inducers GPCR Ligands

Browse the compounds on the LOPAC1280™ Navigator or you can request a complete list of components.

LOPAC¹²⁸⁰™
Format: 250 μL at 10mM in DMSO
Product Number LO1280 (LO3300 outside the U.S.†)

LOPAC¹²⁸⁰™ - Small Scale
Format: 25 μL at 10mM in DMSO
Product Number LO4100 (LO4200 outside the U.S.†)

Compounds are arranged in solution (250 µl at 10 mM in DMSO) in 96-well format in
16 racks of 80, one compound per well.

LOPAC in the Literature

1. Diamandis, P., et. al., Chemical genetics reveals a complex functional ground state of neural stem cells. Nat. Chem. Biol., 3(5):268-273 (2007).
2. Lazo, J.S., et. al., Building a Pharmacological Lexicon : Small Molecule Discovery in Academia. Mol. Pharmacol., 72:1-17 (2007).
3. Rickardson, L., et. al., Image-based screening for the identification of novel proteosome inhibitors. J. Biomol. Screen., 12(2):203-210 (2007).
4. Valley, M.P., et. al., A bioluminescent assay for monoamine oxidase activity. Anal. Biochem., 359(2):238-246 (2006).
5. Rickardson, L., et. al., Screening of an annotated compound library for drug activity in a resistant myeloma cell line. Cancer Chemother. Pharmacol., 58(6):749-758 (2006).
6. Benjamin, E.R., et. al., , State-dependent compound inhibition of Nav1.2 sodium channels using FLIPR Vm dye: on-target and off-target effects of diverse pharmacological agents. J. Biomol. Screen., 11(1)-29-39 (2006).

*Technical information for each compound is provided in standard SDFile format for use with ISIS/Base or other compatible software (software not provided).
 
†Due to import/export restrictions on a small number of LOPAC^1280™ compounds, the International Version (LO3300 and LO4200) will vary slightly from the U.S. Version (LO1280 and LO4100).

Link to Cell Signaling & Neuroscience

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