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POLYPHOSPHOESTERS |
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Biocompatible and Biodegradable |
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Polyphosphoesters exhibit many properties necessary for drug delivery and gene delivery.
- Structurally similar to nucleic and teichoic acids.
- Biodegrade through hydrolysis and possibly enzymatic digestion.
- One of the few classes of polymers for non-viral gene delivery by conjugation of charged groups to the side chain of the phosphate.
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659606 Poly((lactide-co-ethyleneglycol)-co-ethyloxyphosphate)
Poly(LAEG-EOP)
Solubility:
THF: soluble (readily)
Chloroform: soluble (readily)
Acetonitrile: soluble (readily)
Ethyl Acetate: soluble (readily)
Hexane: insoluble |
.bmp)
Change in molecular weight as a function of time, during the in vitro and in vivo degradation of Poly(LAEG-EOP).1 |
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659614 Poly(1,4-bis(hydroxyethyl)terephthalate-co-ethyloxyphosphate)
Poly(BHET-EOP)
Solubility:
THF: insoluble
Hexane: insoluble
Chloroform: soluble (readily)
Methylene chloride: soluble (readily)
Water: swells (opaque solution)
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659738 Poly(1,4-bis(hydroxyethyl)terephthalate-alt-ethyloxyphosphate)-co-1,4-bis(hydroxyethyl)terephthalate-co-terephthalate)
Poly(BHET-EOP/TC, 80/20)
Solubility:
THF: swells (insoluble)
Hexane: swells (insoluble)
Chloroform: soluble
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Reference
1) Zhan, Z. et. al. Adv. Drug Delv. Rev. 2003,55, 483
See also: Penczek, S. et al. Polish J. Chem., 2001, 75, 1171. Penczek, S. et al. Polish J. Chem., 1994, 68, 2129
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