In this issue: Main Article: The Ubiquitin-Proteasome System: Death of Proteins is Required for Life of Cells Aaron Ciechanover New Products Click here to request Celltransmissions Click to download Celltransmissions Vol. 19, No. 3 Click for back issues of Celltransmissions

Product Highlights:

• StarBright® Fluorescent Technology and Novel Quantitative Gene Expression Assays
• L-765,314: A potent and selective a1B adrenoceptor antagonist
  First available from Sigma-RBI!
• SKF-86002 and SB-202190: Potent and selective p38 MAP kinase inhibitors
• Tomoxetine: Selective norepinephrine reuptake inhibitor effective against ADHD
  First available from Sigma-RBI!
• (Z)-Guggulsterone: Farnesoid X receptor (FXR) antagonist
• Leptomycin B: Nuclear export inhibitor
• L-Nafadotride, GR 218231 and GR 103691: D₃ dopamine receptor antagonists
• ABT-491: A potent and selective PAF receptor antagonist
  First available from Sigma-RBI!
• Sobuzoxane: A novel, selective DNA topoisomerase II inhibitor
• Anti-Methyl Histone H3 [Me-Lys⁹]: Heterochromatin assembly marker
• WP900: Highly selective left-handed DNA binding molecule
• Anti-Aurora B: Chromosomal passenger protein
• ALX 5407: A potent, selective, and non-transportable GlyT-1 glycine transporter inhibitor
• Angiostatin and Endostatin: Endogenous inhibitors of angiogenesis
• AMD3100: CXCR4 chemokine receptor antagonist
• Ligand-Sets™ for Assay Validation and High Throughput Screening
• LOPAC^1280™ Library for Assay Validation and High Throughput Screening