TNF-α and TNF-β (LT) Forms and Receptor Binding

TNF-α is expressed on the cell membrane and then hydrolyzed to release the soluble form, which forms homotrimers. TNF-β (LT-α) has no cell membrane attachment domain but can form either membrane-anchored heterotrimers with LT-β or soluble homotrimers. Receptor binding specificities are indicated.

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