[Skip to Content](https://www.sigmaaldrich.com#main-content)
[](https://www.sigmaaldrich.com/US/en)
Products
Cart0
USEN
Products
ProductsApplicationsServicesResourcesSupport
[Login / Register](https://www.sigmaaldrich.com/oidc-sign-in)
[Order Lookup](https://www.sigmaaldrich.com/US/en/order-lookup)
[Quick Order](https://www.sigmaaldrich.com/US/en/quick-order)
Cart0
[Home](https://www.sigmaaldrich.com/US/en)[Applications](https://www.sigmaaldrich.com/US/en/applications)[Research & Disease Areas](https://www.sigmaaldrich.com/US/en/applications/research-disease-areas)Cell Signaling
# Cell Signaling

Cell signaling refers mechanism of communication between cells within organisms driven by mechanical signals, such as touch, or chemical signals, such as hormones, growth factors, and neurotransmitters. In signaling pathways, stimuli are transmitted via a cascade process to yield the correct and appropriate response. Examples of cell signaling pathways include lipid signaling, insulin signaling, stress signaling, growth signaling, TOR signaling, and checkpoint signaling. Research in this field frequently covers studying and modeling cellular dynamics, analyzing cell signaling heterogeneity, crossover between cell signaling and other biological processes, and systematic studies of signaling dynamics.
* * *
## Featured Categories
[")](https://www.sigmaaldrich.com/US/en/products/protein-biology/bioactive-small-molecules)
[Bioactive Small Molecules](https://www.sigmaaldrich.com/US/en/products/protein-biology/bioactive-small-molecules)
Explore 4,000+ potent probes to fine-tune target activity across diverse pathways and major classes. Get expert-designed bioactive small molecules for precise modulation.
[Shop Products](https://www.sigmaaldrich.com/US/en/products/protein-biology/bioactive-small-molecules)
[](https://www.sigmaaldrich.com/US/en/products/protein-biology/bioactive-small-molecules/structural-genomics-consortium)
[Structural Genomics Consortium](https://www.sigmaaldrich.com/US/en/products/protein-biology/bioactive-small-molecules/structural-genomics-consortium)
Structural Genomics Consortium (SGC) chemical probes for target validation and numerous additional research applications and workflow needs.
[Shop Products](https://www.sigmaaldrich.com/US/en/products/protein-biology/bioactive-small-molecules/structural-genomics-consortium)
* * *
Related Articles & Protocols
Support
## Related Articles
- [DNA Damage Response (DDR) Pathway](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/research-and-disease-areas/cancer-research/dna-damage-response-ddr-pathway)
Explore key targets of cancer research and cell signaling research with the DNA damage response (DDR) pathway and do a deep dive into ATM, ATR, and p53 mechanisms involved in DNA damage checkpoints.
- [Lipopolysaccharides](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/research-and-disease-areas/cell-signaling/lipopolysaccharides)
Lipopolysaccharide (LPS) is a major component of Gram-negative bacteria, important for microbiological research.
- [Acetylcholine Synthesis and Metabolism](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/research-and-disease-areas/cell-signaling/acetylcholine-synthesis-and-metabolism)
Acetylcholine is synthesized from acetyl coenzyme A and choline by the enzyme choline acetyltransferase. In addition to its synthesis in the liver, choline employed in acetylcholine production is derived from dietary sources.
- [Tissue Dissociation Guide: Collagenase, Dispase, and Liberase Enzyme Types](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/research-and-disease-areas/cell-signaling/collagenase-guide)
Collagenase Guide.Collagenases, enzymes that break down the native collagen that holds animal tissues together, are made by a variety of microorganisms and by many different animal cells.
- [Glycosaminoglycans and Proteoglycans](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/research-and-disease-areas/cell-signaling/glycosaminoglycans-and-proteoglycans)
Uncover more about glycosaminoglycans and proteoglycans including the structure of glycosaminoglycans (GAGs), the different types of GAGs, and their functions.
- [See All (112)](https://www.sigmaaldrich.com/US/en/search/facet-search?focus=sitecontent&term=facet-search)
## Related Protocols
- [Assay Procedure for Protease](https://www.sigmaaldrich.com/US/en/technical-documents/protocol/protein-biology/enzyme-activity-assays/assay-procedure-for-protease)
This procedure is for informational purposes including assay Procedure, definition, and calculations for Protease
- [Ion Channel Flux Assays and Protocols](https://www.sigmaaldrich.com/US/en/technical-documents/protocol/research-and-disease-areas/cell-signaling/ion-channel-flux-assays-and-protocols)
A review and resources for ion channel flux assays and protocols, along with liposome formation and proteoliposome preparation protocols
- [Assay Procedure for Cholesterol Oxidase](https://www.sigmaaldrich.com/US/en/technical-documents/protocol/research-and-disease-areas/cell-signaling/assay-procedure-for-cholesterol-oxidase)
Protocol for Assay Procedure for Cholesterol Oxidase
- [Protease Fluorescent Detection Kit Usage](https://www.sigmaaldrich.com/US/en/technical-documents/protocol/research-and-disease-areas/cell-signaling/determine-protease-activity-with-protease-fluorescent-detection)
Protease Fluorescent Detection Kit detects protease activity using FITC-labeled casein substrate.
- [See All (10)](https://www.sigmaaldrich.com/US/en/search/facet-search?focus=sitecontent&term=facet-search)
[](https://www.sigmaaldrich.com/documents-search)
[Looking for More Specific Information?](https://www.sigmaaldrich.com/documents-search)
Visit our document search for data sheets, certificates and technical documentation.
[Find Documents](https://www.sigmaaldrich.com/documents-search)
### Find More Articles and Protocols
Enter Keywords
Search
## How Can We Help
In case of any questions, please submit a [customer support request](https://www.sigmaaldrich.com/US/en/support/customer-support)
or talk to our customer service team:
Email [custserv@sial.com](mailto:custserv@sial.com)
or call +1 (800) 244-1173
## Additional Support
- [Chromatogram Search](https://www.sigmaaldrich.com/chromatogram-search)
Use the Chromatogram Search to identify unknown compounds in your sample.
- [Calculators & Apps](https://www.sigmaaldrich.com/US/en/support/calculators-and-apps)
Web Toolbox - science research tools and resources for analytical chemistry, life science, chemical synthesis and materials science.
- [Customer Support Request](https://www.sigmaaldrich.com/US/en/support/customer-support)
Customer support including help with orders, products, accounts, and website technical issues.
- [FAQ](https://maestro.my.site.com/knowledgeportal/s/)
Explore our Frequently Asked Questions for answers to commonly asked questions about our products and services.
* * *
__Featured Articles__
[Interleukin Family (IL)](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/research-and-disease-areas/cell-signaling/interleukin-family)
Interleukins, released from leukocytes, include IL-1β playing crucial roles in inflammation, immune responses, and anti-tumor immunity.
[Troponin](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/research-and-disease-areas/cell-signaling/troponin)
Troponin regulates myosin binding to actin, composed of subunits I, C, and T binding calcium ions.
[Cholesterol Biosynthesis Regulation](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/research-and-disease-areas/cell-signaling/biosynthesis-regulation)
Cholesterol synthesis regulation by dietary levels, LDL receptors control lipid-rich LDL particle transport in cells.
[Vimentin](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/research-and-disease-areas/cell-signaling/vimentin)
Vimentin, an intermediate filamentous protein, contributes to cytoskeletal organization in mesenchymal cells.
Top
__Sign In To Continue__
To continue reading please sign in or create an account.
Sign In__Don't Have An Account?__Register
Support[Customer Support](https://www.sigmaaldrich.com/US/en/support/customer-support)[Contact Us](https://www.sigmaaldrich.com/US/en/collections/offices)[FAQ](https://maestro.my.site.com/knowledgeportal/s/)[Safety Data Sheets (SDS)](https://www.sigmaaldrich.com/US/en/documents-search?tab=sds)[Certificates (COA/COO)](https://www.sigmaaldrich.com/US/en/documents-search?tab=coa)[Quality & Regulatory](https://www.sigmaaldrich.com/US/en/life-science/quality-and-regulatory-management)[Calculators & Apps](https://www.sigmaaldrich.com/US/en/support/calculators-and-apps)[Webinars](https://www.sigmaaldrich.com/US/en/collections/webinars)
Orders[Order Lookup](https://www.sigmaaldrich.com/US/en/order-lookup)[Quick Order](https://www.sigmaaldrich.com/US/en/quick-order)[Custom Products](https://www.sigmaaldrich.com/US/en/services/custom-products)[eCommerce Solutions](https://www.sigmaaldrich.com/US/en/life-science/ecommerce/ecommerce-solutions)
Company[About Us](https://www.sigmaaldrich.com/US/en/life-science/about-us)[Responsibility](https://www.sigmaaldrich.com/US/en/life-science/ssbi)[Events](https://www.sigmaaldrich.com/US/en/collections/events)[Press Releases](https://www.sigmaaldrich.com/US/en/collections/press)[Programs](https://www.sigmaaldrich.com/US/en/life-science/partnership-programs)[Careers](https://careers.merckgroup.com/global/en)[Offices](https://www.sigmaaldrich.com/US/en/collections/offices)
Social Media
[](https://www.linkedin.com/company/merck-life-science)
[](https://x.com/Merck_lifesci)
[](https://www.facebook.com/Merck.lifescience)
[](https://www.instagram.com/mercklifescience/)
[](https://www.youtube.com/@MerckLifeScience/featured)
MilliporeSigma
__Research. Development. Production.__
We are a leading supplier to the global Life Science industry with solutions and services for research, biotechnology development and production, and pharmaceutical drug therapy development and production.
[](https://www.sigmaaldrich.com/US/en)
[Sigma-Aldrich® Solutions](https://www.sigmaaldrich.com/US/en/life-science/sigma-aldrich)[BioReliance® Solutions](https://www.sigmaaldrich.com/US/en/life-science/bioreliance)[Millipore® Solutions](https://www.sigmaaldrich.com/US/en/life-science/millipore)[SAFC® Solutions](https://www.sigmaaldrich.com/US/en/life-science/safc)[Milli-Q® Solutions](https://www.sigmaaldrich.com/US/en/life-science/milliq)[Supelco® Solutions](https://www.sigmaaldrich.com/US/en/life-science/supelco)
© 2026 Merck KGaA, Darmstadt, Germany and/or its affiliates. All Rights Reserved, including Text and Data Mining for AI training and similar technologies.
Reproduction of any materials from the site is strictly forbidden without permission.
[Site Use Terms](https://www.sigmaaldrich.com/US/en/life-science/legal/site-use-terms)|[Privacy Policy](https://www.sigmaaldrich.com/US/en/life-science/legal/privacy-statement)|[General Terms and Conditions of Sale](https://www.sigmaaldrich.com/US/en/life-science/legal/terms-and-conditions)|[Copyright Consent](https://www.sigmaaldrich.com/US/en/life-science/legal/copyright-consent) |[Site Map](https://www.sigmaaldrich.com/US/en/site-map)
An unknown error has occured.