Citalopram: Selective Serotonin Reuptake Inhibitor

Now Available from Sigma-RBI

Prod. No. C 7861

Citalopram (Prod. No. C 7861) belongs to the class of antidepressant drugs known as selective serotonin reuptake inhibitors (SSRIs). SSRIs enhance serotonergic neurotransmission by selectively inhibiting the reuptake of serotonin (Prod. No. H 9523) by serotonergic neurons. This increases the concentration of serotonin in the synaptic cleft and facilitates the activation of pre- and post-synaptic serotonergic receptors. The serotonin transporter (SERT) mediates this reuptake and is the molecular target of SSRIs.^1-3

Sigma-RBI is pleased to introduce Citalopram hydrobromide as a selective serotonin reuptake inhibitor:

• Does not show adverse anticholinergic or cardiovascular effects.
• Blocks both HERG (humanERG1) potassium channels and L-type calcium channels. ⁴
• Inhibits cardiac sodium and calcium channels. ⁵

References

1. Fuller, R.W., Prog. Drug Res., 45, 167-204 (1995).
2. Mortensen, O.V., et al., J. Neurochem., 79, 237-247 (2001).
3. Horschitz, S., et al., Neuroreport, 12, 2181-2184 (2001).
4. Witchel, H.J., et al., FEBS Lett., 512, 59-66 (2002).
5. Pacher, P., et al., Curr. Med. Chem., 6, 469-480 (1999).

Citalopram is featured in Celltransmissions, Volume 18, No. 2. Click here to preview the product highlight.