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Product Code D-187 Related Products
Clone 1-1-F11 S.E6, developed in rat
Ascites fluid
Immunogen: synthetic peptide corresponding to the C-terminus of the human D1 dopamine receptor (97 amino acids)
Isotype: rat IgG2a
Species Reactivity: The antibody recognizes human, monkey and rat D1 dopamine receptors.
Dopamine receptors were initially divided into two general categories on the basis of differences in receptor pharmacology and biochemical mechanisms of signal transduction. With the application of the techniques of molecular biology, two predominant dopamine receptors, D1 and D2, were cloned. Later other dopamine receptors with homology to either the D1 or D2 receptor were identified. Thus, at present, two families of vertebrate dopamine receptors (designated as D1-like and D2-like) are recognized. The D1-like family consists of the D1 and D5 receptors while the D2-like family consists of the D2, D3 and D4 receptors. The D1 and D2 receptors occur in sufficiently high concentrations that they can be studied in situ. The D3, D4 and D5 receptors occur in such low concentrations that study of them in situ is difficult. Thus, the majority of study of these receptors has been accomplished using cell lines cloned to express these receptors.
Applications: Immunoblotting, Immunohistochemistry
| Product Code |
Product Name |
| D6692 |
Anti-D1 Dopamine Receptor antibody produced in rabbit |
| D6817 |
Anti-D4 Dopamine Receptor antibody produced in rabbit |
| D2442 |
Anti-Dopamine Transporter antibody produced in rabbit |
| D-178 |
D1 Dopamine Receptor human, recombinant, expressed in Sf9 cells |
| D-178 |
D2long Dopamine Receptor human, recombinant, expressed in Sf9 cells, membrane suspension |
| D-152 |
D3 Dopamine Receptor human, recombinant, expressed in CCLI-3 cells, membrane suspension |
| D-181 |
D3 Dopamine Receptor rat, recombinant, expressed in Escherichia coli, membrane suspension |
| D-181 |
D3 Dopamine Receptor rat, recombinant, expressed in Escherichia coli, membrane suspension |
| D-181 |
D4.2 Dopamine Receptor human, recombinant, expressed in Sf 9 cells, membrane suspension |
| D-209 |
Dopamine Transporter human, recombinant, expressed in CHO cells, membrane suspension |
References
- Hersch, S.M., et al., Electron microscopic analysis of D1 and D2 dopamine receptor proteins in the dorsal striatum and their synaptic relationships with motor corticostriatal afferents. J. Neurosci., 15, 5222-5237 (1995).
- Levey, A.L., et al., Localization of D1 and D2 dopamine receptors in brain with subtype-specific antibodies. Proc. Natl. Acad. Sci. USA, 90, 8861-8865 (1993).
- Smiley, J.F., et al., D1 dopamine receptor immunoreactivity in human and monkey cerebral cortex: Predominant and extrasynaptic localization in dendritic spines. Proc. Natl. Acad. Sci. USA, 91, 5720-5724 (1994).
- Yung, K.K.L., et al., Immunocytochemical localization of D1 and D2 dopamine receptors in the basal ganglia of the rat: Light and electron microscopy. Neuroscience, 65, 709-730 (1995).
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