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Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily of ligand-activated transcription factors that are related to retinoid, steroid and thyroid hormone receptors. PPARs play an important role in many cellular functions including lipid metabolism, cell proliferation, differentiation, adipogenesis and inflammatory signaling. PPARs have been found to interact with a number of endogenous lipids and drugs for the treatment of human metabolic diseases.
There are three distinct PPAR subtypes that are the products of different genes and are commonly designated PPARa [NR1C1], PPARb (also known as PPARd) [NR1C2] and PPARg [NR1C3]. Each receptor shows a differential pattern of tissue expression and is activated by structurally diverse compounds.
PPARs regulate gene expression by complexing with a heterodimeric partner RXR (retinoid X receptors) and subsequent binding to specific response elements (PPREs) in the promoter regions of target genes. Structurally distinct PPREs are recognized by PPARa, b and g. PPAR-RXR heterodimers can also be activated by ligand binding to either receptor partner independently.
| Product Name |
Product # |
| Azelaoyl PAF |
A6850 |
| 2-Bromohexadecanoic acid |
23,842-2 |
| Ciglitizone |
C3974 |
| Clofibrate |
C6643 |
| 15-Deoxy-d12,14-prostaglandin J2 |
D8440 |
| Fenofibrate |
F6020 |
| Fmoc-Leu-OH |
47633 |
| New GW1929 |
G5668 |
| New GW7647 |
G6793 |
| 8(S)-Hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoic acid (8(S)-HETE) |
H4019 |
| Leukotriene B4 |
L0517 |
| LY-171,883 (Tomelukast) |
L5408 |
| Prostaglandin A2 |
P4547 |
| Prostaglandin J2 |
P9807 |
| New Tetradecylthioacetic acid (TTA) |
T1698 |
| New Troglitazone (CS-045) |
T2573 |
| WY-14643 (Pirinixic acid) |
C7081 |
Technical Links:
Peroxisome Proliferator-Activated Receptors (86kb)
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