Sigma-Aldrich
Apoptosis & Cell Cycle

 Apoptosis & Cell Cycle

Cell Signaling & Neuroscience
 
  Adaptor Proteins
Antibodies to Death Receptor Ligands
Apoptosis Inducers
Apoptosis Inhibitors
Antibodies to Adaptors
Antibodies to DNA Fragmentation
Bcl-2 Family Proteins
Suppressors of Apoptosis
Antibodies to Suppressors of Apoptosis
Death & Decoy Receptors
Cyclins & Nuclear Proteins
Cell Cycle Regulators
Apoptosis and Cell Cycle Table of Contents
Products for Cancer Research Main Index

Adaptor Proteins  
Product Name Product # 
FADD human F1302
Antibodies to Death Receptor Ligands back to top
Product Name Product # 
Anti-APRIL, Extracellular Domain 2 antibody produced in rabbit ~0.5 mg/mL Affinity isolated antibody Buffered aqueous solution A1851
Anti-APRIL, Extracellular Domain antibody produced in rabbit ~0.5 mg/mL Affinity isolated antibody Buffered aqueous solution A1726
Anti-BAFF antibody produced in rabbit ~0.5 mg/mL IgG fraction of antiserum Buffered aqueous solution B4805
Anti-CD30 Ligand antibody produced in goat Affinity isolated antibody Lyophilized powder C5612
Anti-CD40 Ligand antibody produced in goat Affinity isolated antibody Lyophilized powder C6487
Monoclonal Anti-Fas Ligand antibody produced in mouse ~1 mg/mL Clone Alf2.1 Purified immunoglobulin Buffered aqueous solution F2051
Monoclonal Anti-Fas Ligand antibody produced in mouse ~1 mg/mL Clone Alf1.2 Purified immunoglobulin Buffered aqueous solution F1926
Monoclonal Anti-Fas Ligand antibody produced in rat Clone 101624 Purified immunoglobulin Lyophilized powder F2928
Monoclonal Anti-TRAIL antibody produced in mouse Clone 75411.11 Purified immunoglobulin Lyophilized powder T3067
Anti-TRAIL antibody produced in rabbit IgG fraction of antiserum Buffered aqueous solution T9191
Apoptosis Inducers back to top
Product Name Product # 
N-Acetyl-L-cysteine Sigma Grade ³99 % (TLC) powder A7250
N-Acetyl-L-cysteine cell culture tested A9165
N-Acetyl-D-sphingosine ~98 % (TLC) powder A7191
Actinomycin D from Streptomyces sp. ~98 % (HPLC) A1410
Actinomycin D from Streptomyces sp. powder ³95 % cell culture tested A9415
Antimycin A from Streptomyces sp. A8674
Adenosine 3',5'-cyclic monophosphate sodium salt monohydrate ~98 % (HPLC) powder A6885
17-(Allylamino)-17-demethoxygeldanamycin ³98 % (HPLC) solid A8476
Anisomycin from Streptomyces griseolus ~97 % (TLC) solid A9789
Arachidonic acid from porcine liver ~99 % (capillary GC) oil A9673
Arachidonic acid sodium salt from porcine liver ~99 % (capillary GC) powder A8798
Arachidonylethanolamide ~98 % (TLC) oil A0580
Bafilomycin A1 from Streptomyces griseus ³90 % (HPLC) B1793
Berberine chloride B3251
Berberine hemisulfate ³95 % B3412
BH3I-1 ³97 % (HPLC) powder, yellow B8809
Bisbenzimide H 33342 ³95 % (TLC) B2261
Bleomycin sulfate from Streptomyces verticillus crystalline 1.2-1.7 units/mg solid B5507
Bleomycin sulfate from Streptomyces verticillus cell culture tested crystalline 1.2-1.7 units/mg solid B8416
4-Bromo-calcium Ionophore A23187 powder B7272
Butein solid B-178
Sodium butyrate ~99 % B5887
Caffeic acid phenethyl ester >97 % (HPLC and TLC) powder C8221
Calcimycin A23187 ³98 % (TLC) powder C7522
Calcimycin A23187 hemicalcium salt powder C9275
Calcimycin A23187 hemimagnesium salt C9400
Calphostin C from Cladosporium cladosporioides ³90 % (HPLC) powder C6303
(S)-(+)-Camptothecin ~95 % (HPLC) powder C9911
Z-Leu-Leu-Leu-al ³80 % (HPLC) Solid film C2211
Chelerythrine chloride ~95 % (TLC) powder C2932
Colchicine ~95 % (HPLC) powder C9754
Concanamycin A ³70 % (HPLC) C9705
Corticosterone ³92 % C2505
Cycloheximide microbial ³94 % (TLC) C7698
Cycloheximide Ready Made Solution microbial 100 mg/mL in DMSO C4859
Cyclophosphamide monohydrate C0768
Cyclosporin A from Tolypocladium inflatum ³95 % (HPLC) solid C3662
Daunorubicin hydrochloride USP D8809
Demecolcine ³98 % (TLC) D7385
Demecolcine solution liquid 10 µg/mL in HBSS D1925
Dexamethasone ³98 % (HPLC) powder D1756
Dexamethasone powder ³97 % cell culture tested D4902
Dexamethasone powder cell culture tested D8893
Dexamethasone-Water Soluble cell culture tested D2915
Diethylenetriamine/nitric oxide adduct solid D-185
2,5-Dihydroxycinnamic acid methyl ester ³95 % crystalline D2667
Doxorubicin hydrochloride ~98 % (TLC) D1515
Emetine dihydrochloride hydrate E2375
Etoposide synthetic ³98 % powder E1383
5-Fluorouracil ³99 % (TLC) powder F6627
Forskolin Coleus forskohlii ³98 % (HPLC) powder F6886
Fumonisin B1 from Fusarium moniliforme ~98 % (TLC) F1147
Genistein synthetic ³98 % (HPLC) powder G6649
Genistein from Glycine max (soybean) ~98 % (HPLC) G6776
HA 14-1 ³94 % (HPLC) powder H8787
Hexadecyl phosphocholine ~99 % (TLC) H6772
N-Hexanoyl-D-sphingosine semisynthetic from bovine brain D-sphingosine ~98 % (TLC) H6524
Homoharringtonine H0635
15(S)-Hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoic acid ~100 µg/mL in ethanol ³95 % H9521
13(S)-Hydroperoxy-(9Z,11E)-octadecadienoic acid ~100 µg/mL in ethanol ³95 % H9271
Retinoic acid p-hydroxyanilide H7779
Hydroxyurea ³98 % (TLC) powder H8627
Hypericin from Hypericum perforatum ³85 % (HPLC) powder H9252
Ionomycin calcium salt Streptomyces conglobatus ³98 % (TLC) powder I0634
H-7 dihydrochloride I7016
H-89 B1427
KN-93 K1385
Lactacystin ³90 % (TLC) L6785
b-Lapachone 98 % (TLC) L2037
LY-294,002 hydrochloride solid L9908
Methotrexate hydrate powder ³98 % (HPLC) cell culture tested insect cell culture tested M8407
Microcystin LR from Microcystis aeruginosa ³95 % (HPLC) Solid film M2912
Mitomycin C Streptomyces caespitosus M0503
Nifedipine ³98 % (TLC) powder N7634
S-Nitroso-N-acetylpenicillamine ³97 % N3398
S-Nitrosoglutathione ³97 % N4148
Okadaic acid from Prorocentrum concavum ³90 % (HPLC) Translucent film O4511
Okadaic acid ammonium salt from Prorocentrum concavum ³90 % (HPLC) solid O8010
Okadaic acid potassium salt from Prorocentrum concavum ³90 % (HPLC) powder O7885
Okadaic acid sodium salt from Prorocentrum concavum ³90 % (HPLC) Film O7760
Okadaic acid from Prorocentrum concavum ~95 % (HPLC) O9381
Oligomycin Streptomyces diastatochromogenes ~65 % as oligomycin A (Composition given on label) ³90 % as total oligomycins (HPLC) O4876
Paclitaxel from semisynthetic (from Taxus sp.) ³97 % T7191
Paclitaxel from Taxus brevifolia ³95 % (HPLC) powder T7402
Paclitaxel from Taxus yannanensis ³97 % (HPLC) powder T1912
PETCM ³99 % (HPLC) solid P0871
Phorbol 12-myristate 13-acetate ³99 % (TLC) Film or powder P8139
Puromycin dihydrochloride from Streptomyces alboniger ³98 % (TLC) powder P7255
Ammonium pyrrolidinedithiocarbamate ~99 % P8765
Quercetin dihydrate ³98 % (HPLC) powder Q0125
Rapamycin from Streptomyces hygroscopicus ³95 % (HPLC) powder R0395
Spermine ~97 % S3256
Spermine cell culture tested ³96 % Amorphous semi-solid S4264
Spermine tetrahydrochloride ³95 % (TLC) S2876
D-Sphingosine synthetic S7049
Staurosporine Streptomyces sp. ³95 % (HPLC) solid S4400
Streptonigrin from Streptomyces flocculus ³98 % S1014
Sulindac Sulfide S3131
Sulindac sulfone 99 % (TLC) solid S1438
Tamoxifen ³99 % T5648
Tamoxifen citrate salt ³99 % T9262
N,N,N',N'-Tetrakis(2-pyridylmethyl)ethylenediamine P4413
4-Hydroxytamoxifen ³98 % (TLC) powder H7904
4-Hydroxytamoxifen Minimum 70% of Z isomer (remainder primarily E-isomer) H6278
Thapsigargin ³90 % (HPLC) Liquid or film T9033
Triptolide from Tripterygium wilfordii ³98 % (HPLC) solid T3652
Tyrphostin AG 490 solid T3434
Valinomycin ³90 % (HPLC) solid V0627
(±)-Verapamil hydrochloride ³99.0 % (titration) powder V4629
Veratridine ³90 % (TLC) powder V5754
Vinblastine sulfate salt ³97 % (TLC) powder V1377
Apoptosis Inhibitors back to top
Product Name Product # 
N-Acetyl-L-cysteine Sigma Grade ³99 % (TLC) powder A7250
N-Acetyl-L-cysteine cell culture tested A9165
Actinomycin D from Streptomyces sp. ~98 % (HPLC) A1410
Actinomycin D from Streptomyces sp. powder ³95 % cell culture tested A9415
Calpain Inhibitor II ³97 % (TLC) powder A6060
Calpain Inhibitor I ³97 % (TLC) powder A6185
3-Aminobenzamide ³99 % (TLC) A0788
Aphidicolin Nigrospora sphaerica ³98 % (GC) powder A0781
Aurintricarboxylic acid practical grade ³85 % (titration) powder A1895
Bongkrekic acid solution 1 mg/mL in 0.01 M Tris buffer, pH 7.5 ³95 % (HPLC) from Pseudomonas cocovenenans B6179
Caffeine ReagentPlusä powder C0750
Calcimycin A23187 ³98 % (TLC) powder C7522
Calcimycin A23187 hemicalcium salt powder C9275
Calcimycin A23187 hemimagnesium salt C9400
Calyculin A from Discodermia calyx ~90 % (HPLC) solid C5552
Cycloheximide microbial ³94 % (TLC) C7698
Cyclosporin A from Tolypocladium inflatum ³95 % (HPLC) solid C3662
3,4-Dichloroisocoumarin D7910
Diisopropyl fluorophosphate D0879
Emetine dihydrochloride hydrate E2375
N-Ethylmaleimide SigmaUltra E1271
N-Ethylmaleimide crystalline ³98 % (HPLC) E3876
Genistein synthetic ³98 % (HPLC) powder G6649
Genistein from Glycine max (soybean) ~98 % (HPLC) G6776
Guanosine 3',5'-cyclic monophosphate sodium salt ³98 % (HPLC) powder G6129
Hemoglobin from bovine blood Lyophilized powder H2500
Herbimycin A from Streptomyces hygroscopicus ³95 % (HPLC) powder H6649
Insulin-like Growth Factor-I human ³97 % (SDS-PAGE or HPLC) recombinant, expressed in Escherichia coli Lyophilized powder cell culture tested I3769
Interleukin-1b rat ³98 % (SDS-PAGE and HPLC) recombinant, expressed in Escherichia coli Lyophilized powder cell culture tested I2393
Interleukin-1b human ³98 % (SDS-PAGE and HPLC) recombinant, expressed in Escherichia coli Lyophilized powder I9401
Interleukin-1b from mouse ³98 % (SDS-PAGE and HPLC) recombinant, expressed in Escherichia coli Lyophilized powder cell culture tested I5271
Interleukin-6 from mouse ³98 % (SDS-PAGE and HPLC) recombinant, expressed in Escherichia coli Lyophilized powder cell culture tested I9646
Interleukin-6 human ³97 % (SDS-PAGE) recombinant, expressed in Escherichia coli Lyophilized powder cell culture tested I1395
Leupeptin hydrochloride microbial ³70 % (HPLC) L0649
Leupeptin hemisulfate salt microbial ³90 % (HPLC) L2884
Leupeptin trifluoroacetate salt ³90 % (HPLC) microbial L2023
MDL 28170 ³95 % (HPLC) M6690
Pifithrin-a ³95 % (HPLC) powder P4359
Cyclic Pifithrin-a >95 % (HPLC) P4236
Phenylarsine oxide ³97 % powder P3075
Phenylmethanesulfonyl fluoride >99 % (GC) P7626
Phorbol 12,13-dibutyrate ³98 % (TLC) powder P1269
Ammonium pyrrolidinedithiocarbamate ~99 % P8765
SB 203580 powder S8307
Spermine ~97 % S3256
Spermine cell culture tested ³96 % Amorphous semi-solid S4264
Spermine tetrahydrochloride ³95 % (TLC) S2876
Superoxide Dismutase bovine erythrocytes Lyophilized powder 2,500-7,000 units/mg protein S2515
Superoxide Dismutase bovine erythrocytes cell culture tested Lyophilized powder 2,500-7,000 units/mg protein S5395
Superoxide Dismutase from human erythrocytes Lyophilized powder ³99 % ³1,350 units/mg protein S9636
Na-p-Tosyl-L-lysine chloromethyl ketone hydrochloride ³97 % (TLC) powder T7254
(±)-Verapamil hydrochloride ³99.0 % (titration) powder V4629
Antibodies to Adaptors back to top
Product Name Product # 
Anti-ASC/TMS1 antibody produced in rabbit ~0.5 mg/mL Affinity isolated antibody Buffered aqueous solution A1601
Anti-Daxx antibody produced in rabbit IgG fraction of antiserum Buffered aqueous solution D7810
Monoclonal Anti-FADD antibody produced in mouse ~2 mg/mL Clone FD19 Purified immunoglobulin Buffered aqueous solution F8053
Anti-MADD antibody produced in rabbit IgG fraction of antiserum Buffered aqueous solution M5683
Anti-MyD88, C-Terminal antibody produced in rabbit ~0.5 mg/mL Affinity isolated antibody Buffered aqueous solution M9934
Anti-MyD88, Internal Domain antibody produced in rabbit ~0.5 mg/mL Affinity isolated antibody Buffered aqueous solution M0185
Anti-RAIDD antibody produced in rabbit IgG fraction of antiserum Buffered aqueous solution R5275
Anti-RAIDD, Internal Domain antibody produced in rabbit ~0.5 mg/mL IgG fraction of antiserum R9775
Anti-RIP (Receptor Interacting Protein) antibody produced in rabbit Affinity isolated antibody Buffered aqueous solution R8274
Anti-RIP3 antibody produced in rabbit ~0.5 mg/mL Affinity isolated antibody Buffered aqueous solution R4277
Antibodies to DNA Fragmentation back to top
Product Name Product # 
Anti-CAD antibody produced in rabbit Affinity isolated antibody Buffered aqueous solution C7852
Anti-CIDE-A, C-Terminal antibody produced in rabbit Affinity isolated antibody Buffered aqueous solution C7977
Anti-CIDE-A, C-Terminal antibody produced in rabbit ~0.5 mg/mL Affinity isolated antibody Buffered aqueous solution C7987
Anti-CIDE-B, C-Terminal antibody produced in rabbit Affinity isolated antibody Buffered aqueous solution C8102
Anti-Deoxyribonuclease I (DNase I) antibody produced in rabbit IgG fraction of antiserum Buffered aqueous solution D0188
Anti-Deoxyribonuclease II (DNase II) antibody produced in rabbit ~0.5 mg/mL Affinity isolated antibody D1689
Anti-Endonuclease G antibody produced in rabbit ~1 mg/mL Affinity isolated antibody Buffered aqueous solution E5654
Monoclonal Anti-Excision Repair Cross Complementing Protein-1 antibody produced in mouse ~1 mg/mL Clone 8F1 Purified immunoglobulin Buffered aqueous solution E8903
Anti-DFF45, C-Terminal antibody produced in rabbit Affinity isolated antibody Buffered aqueous solution I7653
Anti-DFF45, C-Terminal antibody produced in rabbit IgG fraction of antiserum Buffered aqueous solution D3313
Anti-DFF45, N-Terminal antibody produced in rabbit IgG fraction of antiserum Buffered aqueous solution D3438
Anti-DFF45, N-Terminal antibody produced in rabbit Affinity isolated antibody Buffered aqueous solution I7528
Monoclonal Anti-Thymine Dimer antibody produced in mouse ~2 mg/mL Clone H3 Purified immunoglobulin Buffered aqueous solution T1192
Bcl-2 Family Proteins back to top
Product Name Product # 
BAD from mouse ³70 % (SDS-PAGE) recombinant, expressed in Escherichia coli Buffered aqueous glycerol solution B1682
Bcl-2 human ³90 % (SDS-PAGE) recombinant, expressed in Escherichia coli (Maltose Binding Protein (MBP) fusion protein, C-terminal truncated) Buffered aqueous glycerol solution B1182
Bcl-w (Minus C-Terminus) human >95 % (SDS-PAGE) recombinant, expressed in Escherichia coli Buffered aqueous glycerol solution B1059
Bcl-xL (Minus C-Terminus) human ~95 % (SDS-PAGE) recombinant, expressed in Escherichia coli Buffered aqueous solution B0934
Bcl-xL (Minus C-Terminus) mouse ³95 % (SDS-PAGE) recombinant, expressed in Escherichia coli Buffered aqueous solution B8056
BID from mouse ³95 % (SDS-PAGE) recombinant, expressed in Escherichia coli Buffered aqueous solution B8306
BID human ³95 % (SDS-PAGE) recombinant, expressed in Escherichia coli Buffered aqueous solution B8181
BID, Caspase-8-cleaved from mouse ³95 % (SDS-PAGE) recombinant, expressed in Escherichia coli Buffered aqueous solution C4733
BID, Caspase-8-cleaved human ³95 % (SDS-PAGE) recombinant, expressed in Escherichia coli Buffered aqueous solution C4608
Suppressors of Apoptosis back to top
Product Name Product # 
Livin β/ML-IAP human > 95 % SDS-PAGE, Escherichia coli, Buffered aqueous solution L1040
XIAP human > 95 % SDS-PAGE, Escherichia coli, Buffered aqueous solution X3378
Antibodies to Suppressors of Apoptosis back to top
Product Name Product # 
Anti- FLIP, N-Terminal antibody produced in rabbit ~0.5 mg/mL Affinity isolated antibody Buffered aqueous solution F9800
Anti-FLIPa, C-Terminal antibody produced in rabbit IgG fraction of antiserum Buffered aqueous solution F6550
Anti-FLIPg/d, C-Terminal antibody produced in rabbit ~0.5 mg/mL Affinity isolated antibody Buffered aqueous solution F9925
Anti-FLIPL C-Terminal antibody produced in rabbit ~0.5 mg/mL IgG fraction of antiserum Buffered aqueous solution F9675
Anti-ILP-2 antibody produced in rabbit ~1 mg/mL Affinity isolated antibody Buffered aqueous solution I4782
Anti-NAIP antibody produced in rabbit Affinity isolated antibody Lyophilized powder N6648
Anti-Survivin antibody produced in rabbit IgG fraction of antiserum Buffered aqueous solution S8191
Anti-XIAP antibody produced in rabbit Affinity isolated antibody Lyophilized powder X2503
Death & Decoy Receptors back to top
Product Name Product # 
CD30/Fc Chimera human >95 % (SDS-PAGE) recombinant, expressed in mouse NSO cells Lyophilized powder C5862
DcR1/Fc Chimera human ³95 % (SDS-PAGE) recombinant, expressed in mouse NSO cells Lyophilized powder cell culture tested D9688
DcR2/Fc Chimera human ³95 % (SDS-PAGE) recombinant, expressed in mouse NSO cells Lyophilized powder cell culture tested D9813
DcR3/Fc Chimera human >90 % (SDS-PAGE) recombinant, expressed in Sf 21 cells Lyophilized powder D2441
DR4/Fc Chimera human ³97 % (SDS-PAGE) recombinant, expressed in Sf 21 cells Lyophilized powder cell culture tested D9438
DR5/Fc Chimera human ³95 % (SDS-PAGE) recombinant, expressed in mouse NSO cells Lyophilized powder cell culture tested D9563
Fas/Fc Chimera human ³97 % (SDS-PAGE) recombinant, expressed in mouse NSO cells Lyophilized powder cell culture tested F8674
Fas/Fc Chimera mouse ³97 % (SDS-PAGE) recombinant, expressed in Sf 21 cells Lyophilized powder cell culture tested F8799
Fas Intracellular Domain human >90 % (SDS-PAGE) recombinant, expressed in Escherichia coli (N-terminal histidine tagged) Buffered aqueous solution F2053
TRAIL Receptor 2/Fc Chimera from mouse >95 % (SDS-PAGE) recombinant, expressed in Sf 21 cells Lyophilized powder T5819
Cyclins & Nuclear Proteins back to top
Product Name Product # 
Cdc25A, active human ~30 % recombinant, expressed in E. coli Buffered aqueous glycerol solution ~42,000 units/mg protein C7484
Cdc25B, active human ~30 % recombinant, expressed in E. coli Buffered aqueous glycerol solution ~3,000 units/mg C7609
Cyclin-dependent Kinase 2 human C8864
Cyclin-dependent Kinase 5 human C8739
p13suc1-Agarose P3104
PSTAIRE peptide ³95 % (HPLC) P4480
Wee1, active from rat N-terminal GST-tagged solution W4387
Cell Cycle Regulators back to top
Product Name Product # 
Aphidicolin Nigrospora sphaerica ³98 % (GC) powder A0781
Apigenin ~95 % (TLC) from parsley powder A3145
(-)-Blebbistatin 398 % solid from synthetic B0560
CGP-74514A hydrochloride C3353
Compound 52 ³98 % powder C2604
Daidzein ³98 % synthetic D7802
Destruxin A from Metarhizium anisopliae ³90 % (HPLC) D4921
DIF-3 399 % (HPLC) solid D0567
p-Fluoro-L-phenylalanine F4646
5-Fluorouracil ³99 % (TLC) powder F6627
Homoharringtonine H0635
Indirubin-3'-oxime I0404
N9-Isopropylolomoucine ³98 % (HPLC) I0763
Kenpaullone ³99 % K3888
L-Mimosine from Koa hoale seeds ³98 % M0253
Mizoribine ³98 % (TLC) M3047
Monastrol ³95 % (HPLC) M8515
Netropsin dihydrochloride from Streptomyces netropsis ³98 % (TLC and HPLC) powder N9653
Olomoucine ³98 % (HPLC) O0886
[Ala92]-Peptide 6 P7967
Purvalanol A ³98 % (HPLC) powder P4484
Roscovitine ³98 % (TLC) R7772
Se-(Methyl)selenocysteine hydrochloride ³95 % (TLC) M6680
Sobuzoxane ³99 % (HPLC) solid S4692
TCPOBOP ³98 % (HPLC) solid T1443
Trichostatin A from Streptomyces sp. ³98 % (HPLC) T8552
Verruculogen from Penicillium verruculosum ~95 % V7755
WP631 methanesulfonate ³97 % (HPLC) solid W3763
XK469 ³98 % (HPLC) solid X3628
  back to top