Sigma-Aldrich
Apoptosis & Cell Cycle

 Caspases

Cell Signaling & Neuroscience
 
  Kits
Cathespins and Granzymes
Enzymes
Antibodies
Inhibitors
Substrates
Apoptosis and Cell Cycle Table of Contents

Pathway Slide: Caspase Cascade
Pathway Slide: Caspase Activation Intrinsic Pathway

Kits  
Product Name Product # 
Caspase 3 Assay Kit, Colorimetric CASP-3-C
Caspase 3 Assay Kit, Fluorimetric CASP-3-F
Caspase 6 Assay Kit, Fluorimetric CASP-6-F
Caspase 8 Assay Kit, Colorimetric CASP-8-C
Caspase 8 Assay Kit, Fluorimetric CASP-8-F
Caspase Fluorescein (FLICA) Assay sufficient for 100 tests, Caspase 1 Fluorescein (FLICA) Assay CS0280
Caspase Fluorescein (FLICA) Assay sufficient for 100 tests, Caspase 2 Fluorescein (FLICA) Assay CS0290
Caspase Fluorescein (FLICA) Assay sufficient for 100 tests, Caspase 9 Fluorescein (FLICA) Assay CS0300
Caspase Fluorescein (FLICA) Assay sufficient for 100 tests, Caspase 10 Fluorescein (FLICA) Assay CS0310
Caspase Fluorescein (FLICA) Assay sufficient for 100 tests, Caspase 13 Fluorescein (FLICA) Assay CS0320
Cathespins and Granzymes back to top
Product Name Product # 
Cathepsin Detection Assay  assays sufficient for 100 Cathepsin B Detection Assay CS0370
Cathepsin Detection Assay Cathepsin K Detection Assay 100 assays sufficient for CS0360
Cathepsin Detection Assay Cathepsin L Detection Assay 100 assays sufficient for CS0350
Enzymes back to top
Product Name Product # 
Caspase 1 human recombinant, expressed in Escherichia coli 8000 units/mg protein C5482
Caspase 2 human ³95 % (SDS-PAGE) recombinant, expressed in Escherichia coli Buffered aqueous solution >1000 units/mg protein C2854
Caspase 3 human ³90 % (SDS-PAGE) recombinant, expressed in Escherichia coli (C-terminal histidine-tagged) Buffered aqueous glycerol solution >1.0 units/mg protein C1224
Caspase 4 human recombinant, expressed in Escherichia coli 5,000 units/mg protein C6357
Caspase 5 human recombinant, expressed in Escherichia coli 5,000 units/mg protein C6482
Caspase 6 human ³90 % (SDS-PAGE) recombinant, expressed in Escherichia coli Buffered aqueous solution >1,000 units/mg protein C-terminal histidine tagged C4977
Caspase 7 human ³95 % (SDS-PAGE) recombinant, expressed in Escherichia coli Buffered aqueous solution ³4,000 units/mg protein C2979
Caspase 8 human ³90 % (SDS-PAGE) recombinant, expressed in Escherichia coli (C-terminal histidine tagged) Buffered aqueous solution ³1,000 units/mg protein C1099
Caspase 9 human ³90 % (SDS-PAGE) recombinant, expressed in Escherichia coli (C-terminal histidine-tagged) Buffered aqueous solution >2,000 units/mg protein C8726
Caspase 10 human recombinant, expressed in Escherichia coli >90 % (SDS-PAGE) Lyophilized powder 8,000 units/mg protein C7982
Caspase 10 human >90 % (SDS-PAGE) recombinant, expressed in Escherichia coli Lyophilized powder 8,000 units/mg protein (Bradford) C6607
Caspase Combo I, Type 1, 4, and 5 >90 % (SDS-PAGE) recombinant, expressed in Escherichia coli Lyophilized powder C8107
Caspase Combo II, Type 2, 3, and 7 >90 % (SDS-PAGE) recombinant, expressed in Escherichia coli Lyophilized powder C8232
Caspase Combo III, Type 6, 8, 9 and 10 human >90 % (SDS-PAGE) recombinant, expressed in Escherichia coli Lyophilized powder C8357
Procaspase-3 human >90 % (SDS-PAGE) recombinant, expressed in Escherichia coli P1488
Antibodies back to top
Product Name Product # 
Caspase 1
Anti-Caspase 1 (ICE) antibody produced in rabbit IgG fraction of antiserum Buffered aqueous solution C4851
Caspase 2
Anti-Caspase 2 antibody produced in rabbit IgG fraction of antiserum Buffered aqueous solution C7349
Caspase 3
Anti-Caspase 3 antibody produced in rabbit IgG fraction of antiserum Buffered aqueous solution C9598
Anti-Caspase 3, Active antibody produced in rabbit IgG fraction of antiserum Buffered aqueous solution C8487
Monoclonal Anti-Caspase 3 antibody produced in mouse Clone 84803.111 Purified immunoglobulin Lyophilized powder C5737
Caspase 4
Monoclonal Anti-Caspase 4 antibody produced in mouse ~2 mg/mL Clone CAS4 Purified immunoglobulin Buffered aqueous solution C3392
Anti-Caspase 4 antibody produced in rabbit Affinity isolated antibody Buffered aqueous solution C4481
Caspase 5
Monoclonal Anti-Caspase 5 antibody produced in mouse ~2 mg/mL Clone CAS5 Purified immunoglobulin Buffered aqueous solution C6979
Caspase 6
Anti-Caspase 6 antibody produced in rabbit Affinity isolated antibody Buffered aqueous solution C7599
Caspase 7 human
Anti-Caspase 7 antibody produced in rabbit Affinity isolated antibody Buffered aqueous solution C7724
Monoclonal Anti-Caspase 7 antibody produced in rat Clone 11E4 Purified immunoglobulin Buffered aqueous solution C1104
Caspase 8
Anti-Caspase 8 (GD-13) antibody produced in rabbit IgG fraction of antiserum Buffered aqueous solution C2976
Anti-Caspase 8 (SK-16) antibody produced in rabbit IgG fraction of antiserum Buffered aqueous solution C3101
Monoclonal Anti-Caspase 8 antibody produced in mouse ~2 mg/mL Clone CAS8 Purified immunoglobulin Buffered aqueous solution C4106
Anti-pro-Caspase 8 antibody produced in rabbit IgG fraction of antiserum Buffered aqueous solution C7849
Caspase 9
Monoclonal Anti-Caspase 9 antibody produced in mouse ~2 mg/mL Clone CAS9 Purified immunoglobulin Buffered aqueous solution C4356
Anti-Caspase 9 antibody produced in rabbit Affinity isolated antibody Buffered aqueous solution C7729
Anti-Caspase 9 antibody produced in rabbit Cleavage site (315/316) specific Buffered aqueous solution Affinity isolated antibody C9235
Caspase 10
Anti-Caspase 10 antibody produced in rabbit Affinity isolated antibody Buffered aqueous solution C8351
Monoclonal Anti-Caspase 10 antibody produced in rat Clone 25C2 Purified immunoglobulin Buffered aqueous solution C1229
Monoclonal Anti-Caspase 11 antibody produced in rat ~1 mg/mL Clone 17D9 Purified immunoglobulin Buffered aqueous solution C1354
Monoclonal Anti-Caspase 12 antibody produced in rat Clone 14F7 Purified immunoglobulin Buffered aqueous solution C7611
Anti-Caspase 13 (ERICE) antibody produced in rabbit ~0.5 mg/mL IgG fraction of antiserum Buffered aqueous solution C8854
Inhibitors back to top
Product Name Product # 
General
Biotin-Val-Ala-Asp(OMe)-fluoromethyl ketone ³98 % (TLC) B2057
Boc-Asp(OMe)-fluoromethyl ketone ³98 % (TLC) solid B2682
p35 from baculovirus ³90 % (SDS-PAGE) recombinant, expressed in Escherichia coli C-terminal His6tag Buffered aqueous glycerol solution ³5000 units/mg protein P9361
Z-Ala-Glu(OMe)-Val-Asp(OMe)-fluoromethyl ketone solid C8484
Z-VAD-FMK solid V-116
Z-Val-Ala-Asp fluoromethyl ketone C2105
Z-Val-Lys(Biotin)-Asp(OMe)-fluoromethyl ketone ³98 % (TLC) solid C8609
Caspase 1
N-Acetyl-Tyr-Val-Lys(biotinyl)-Asp 2,6-dimethylbenzoyloxymethyl ketone ³90 % (HPLC) powder A4339
N-Acetyl-Tyr-Val-Ala-Asp chloromethyl ketone ³90 % (HPLC) A4211
Z-Leu-Glu(OMe)-Val-Asp(OMe)-fluoromethyl ketone ~90 % (TLC) solid C9484
Z-Tyr-Val-Ala-Asp(OMe) fluoromethyl ketone powder C1980
Caspase 2
Z-Val-Asp(O-Me)-Val-Ala-Asp(O-Me) fluoromethyl ketone powder C1605
Caspase 3
N-Acetyl-Asp-Glu-Val-Asp-al ³95 % powder A0835
N-Acetyl-Glu-Ser-Met-Asp-al ³90 % (HPLC) powder A1341
N-Acetyl-Ile-Glu-Thr-Asp-al ~99 % (TLC) powder A1216
Biotin-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethyl ketone ³98 % (TLC) solid B1807
Biotinyl-Asp-Glu-Val-Asp-al B7795
Z-Asp(OMe)-Gln-Met-Asp(OMe) fluoromethyl ketone powder C0480
Z-Asp(O-Me)-Glu(O-Me)-Val-Asp(O-Me) fluoromethyl ketone ³95 % (TLC) C0605
Caspase 4
N-Acetyl-Leu-Glu-Val-Asp-CHO trifluoroacetate salt powder >95 % (HPLC) C0859
LEVD-CHO, cell permeable trifluoroacetate salt ³90 % (HPLC) Lyophilized powder L1039
Caspase 5
N-Acetyl-Trp-Glu-His-Asp-al ³80 % (HPLC) powder A1466
Z-Trp-Glu(O-Me)-His-Asp(O-Me) fluoromethyl ketone crystalline C1855
Caspase 6
N-Acetyl-Val-Glu-Ile-Asp-al ~99 % (HPLC) powder A6339
Z-Val-Glu(O-Me)-Ile-Asp(O-Me) fluoromethyl ketone powder C1730
Caspase 8
Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone ³95 % (TLC) powder C1230
Z-Leu-Glu(OMe)-Thr-Asp(OMe)-fluoromethyl ketone ³98 % (TLC) solid C8734
Caspase 9
Z-Leu-Glu(O-ME)-His-Asp(O-Me) fluoromethyl ketone powder C1355
Caspase 13
Z-Leu-Glu(OMe)-Glu(OMe)-Asp(OMe)-fluoromethyl ketone ³98 % (TLC) solid C8859
Negative Control
Z-Phe-Ala fluoromethyl ketone ³90 % (TLC) powder C1480
Substrates back to top
Product Name Product # 
General
ChromoFluor96 CF96-101
N-Acetyl-Val-Ala-Asp-7-amido-4-trifluoromethylcoumarin >98 % (HPLC) solid A0723
N-Acetyl-Val-Ala-Asp p-nitroanilide >98 % (HPLC) solid A0848
Caspase 1
N-Acetyl-Trp-Glu-His-Asp-7-amido-4-methylcoumarin ³97 % (HPLC) powder A0216
N-Acetyl-Tyr-Val-Ala-Asp-7-amido-4-methylcoumarin ³99 % (TLC) powder A2452
N-Acetyl-Tyr-Val-Ala-Asp-7-amido-4-trifluoromethylcoumarin ³95 % (HPLC) powder A9965
Z-Tyr-Val-Ala-Asp-p-nitroanilide trifluoroacetate salt ³90 % (HPLC) C6234
Caspase 2
N-Acetyl-Asp-Glu-His-Asp-7-amido-4-methylcoumarin trifluoroacetate salt ³95 % (HPLC) A9598
N-Acetyl-Val-Asp-Val-Ala-Asp-7-amido-4-trifluoromethylcoumarin ³97 % (HPLC) powder A5345
N-Acetyl-Val-Asp-Val-Ala-Asp-p-nitroanilide ³97 % (HPLC) powder A5470
Caspase 3
N-Acetyl-Asp-Gln-Met-Asp-7-amido-4-trifluoromethylcoumarin ³90 % (HPLC) powder A5595
N-Acetyl-Asp-Glu-Val-Asp p-nitroanilide ³97 % (HPLC) powder A2559
N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-methylcoumarin ³97 % (HPLC) powder A1086
N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-trifluoromethylcoumarin ³90 % (HPLC) powder A0466
DFF45/ICAD human >85 % (SDS-PAGE) recombinant, expressed in Escherichia coli solution D3815
7-Methoxycoumarin-4-acetyl-Asp-Glu-Val-Asp-Ala-Pro-(2,4-dinitrophenyl)Lys M1169
Z-Asp-Glu-Val-Asp-p-nitroanilide trifluoroacetate salt ³97 % (HPLC) Lyophilized powder C6109
Caspase 4
N-Acetyl-Leu-Glu-Val-Asp-7-amido-4-trifluoromethylcoumarin ³95 % (HPLC) solid A2099
Caspase 5
N-Acetyl-Trp-Glu-His-Asp-7-amido-4-trifluoromethylcoumarin trifluoroacetate salt ³97 % (HPLC) powder A6720
N-Acetyl-Trp-Glu-His-Asp-p-nitroanilide ³98 % (HPLC) powder A6845
Caspase 6
N-Acetyl-Val-Glu-His-Asp-7-amido-4-methylcoumarin >97 % (HPLC) Lyophilized powder A9973
N-Acetyl-Val-Glu-Ile-Asp-7-amido-4-methylcoumarin ³90 % (HPLC) powder A0341
N-Acetyl-Val-Glu-Ile-Asp-7-amido-4-trifluoromethylcoumarin ³97 % (HPLC) powder A5095
N-Acetyl-Val-Glu-Ile-Asp-p-nitroanilide ³97 % (HPLC) powder A5220
Z-Val-Glu-Ile-Asp-pNA ³96 % (HPLC) Lyophilized powder C6359
Caspase 8
N-Acetyl-Ala-Glu-Val-Asp-7-amido-4-trifluoromethylcoumarin >96 % (HPLC) solid A0973
N-Acetyl-Ile-Glu-Thr-Asp-7-Amido-4-methylcoumarin ³97 % (HPLC) powder A4188
N-Acetyl-Ile-Glu-Thr-Asp-p-nitroanilide ³95 % A9968
N-Acetyl-Leu-Glu-Thr-Asp-7-Amido-4-trifluoromethylcoumarin ³97 % (HPLC) powder A6095
Z-Ile-Glu-Thr-Asp 7-amido-4-trifluoromethylcoumarin ³95 % (HPLC) C5599
Z-Ile-Glu-Thr-Asp-pNA trifluoroacetate salt ³97 % (HPLC) Lyophilized powder C6484
Caspase 9
N-Acetyl-Leu-Glu-His-Asp-7-amido-4-trifluoromethylcoumarin ³95 % (HPLC) powder A5845
N-Acetyl-Leu-Glu-His-Asp-p-nitroanilide ³95 % (HPLC) powder A5970
Caspase 13
N-Acetyl-Leu-Glu-Glu-Asp-7-amido-4-trifluoromethylcoumarin ³90 % (HPLC) powder A5720
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