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PathFinder

 Cell Signaling Pathway Slides & Charts

Cell Signaling & Neuroscience
 

The free Pathway Slides are part of Sigma's growing offering in Cell Signaling and Neuroscience. You can download these slides for your personal use or for educational presentations.

Following the link will launch the interactive PathFinder graphics with more detailed information on similar or related pathways.

Register for our Cell Signaling & Neuroscience Program and receive additional information targeted to your research area.

Cell Signaling & Neuroscience Pathway Slides

Slide Categories:
   Apoptosis and Cell Cycle
   Cytokines, Growth Factors and Hormones
   Cytoskeleton and Extracellular Matrix
   Gene Regulation and Expression
   G Proteins and Cyclic Nucleotides
   Immune Cell Signaling and Blood
   Ion Channels
   Lipids in Cell Signaling
   Multi-Drug Resistance
   Neurobiology
   Neurotransmission
   Nitric Oxide and Cell Stress
   Protein Phosphorylation
    

Slide No.
Slide Titles
back to top APOPTOSIS AND CELL CYCLE  
1 Programmed Cell Death  
2 Activation and Inhibition of Apoptosis  
3 Mitochondria in Apoptosis  
4 ATM/p53 Signaling Pathway
5 Caspase Cascade
6 Caspase Activation Intrinsic Pathway  
7 Granzyme B  
8 Fas and Related Proteins with Death Domains  
9 Fas Signaling Pathway  
10 G1 and S Phases of the Cell Cycle  
11 G2 and M Phases of the Cell Cycle  
12 Regulatory Cascade of Cyclin Gene Expression  
13 The p53 Signaling Pathway
back to top CYTOKINES, GROWTH FACTORS AND HORMONES  
14 Cytokines, Growth Factors and Hormones
15 Structures of Activin and Inhibin Prototypes and Precursors  
16 Structures of Three Chemokine Receptors  
17 Angiopoietins and their receptors, Tie1 and Tie2  
18 EGF Receptor Signal Transduction Pathway
19 Transmembrane Precursors of EGF Family Members  
20 Possible Receptor Combinations and Ligand–binding with EGF and HGF Families  
21 Actions of Flt-3/Flk-2 Ligand on B Cell Lymphopoiesis in Bone Marrow
22 IGF Regulation of Apoptosis  
23 IL-13 and IL-4 receptor combinations and binding  
24 IL-18 Production and Role in Immune Response  
25 Neurotrophins and Their Receptors  
26 TrkA Receptor  
27 GDNF Family with Receptors  
28 PDGF Receptors and Actions  
29 Signaling Pathway of TGF-b  
30 Bone Morphogenic Protein  
31 TNF Signaling Pathway  
32 TNF-α and TNF-β (LT) Forms and Receptor Binding  
33 Proposed Balance Between TNF Superfamily Members in Relation to Bone Formation or Destruction  
34 Structure of Receptors and Growth Factors Involved in Vasculogenesis, Angiogenesis and Lymphomagenesis  
35 VEGF Receptor and Ligands  
36 Signal Transduction Pathways Involved in Prolactin Regulation  
37 Insulin Pathway
38 Glucocorticoid Receptor Signaling  
back to top CYTOSKELETON AND EXTRACELLULAR MATRIX  
39 Vascular Endothelial Cell Interactions and Signaling  
40 Integrin Signaling in Cell Survival and Death
41 VEGF Receptor Signaling  
42 The MMP/Cytokine Connection  
43 Events Leading to Angiogenesis and Metastasis  
back to top GENE REGULATION AND EXPRESSION  
44 Transcription Factor Regulation (CREB, Elk-1 and c-Fos)  
45 Hormonal Targeting of Nuclear Complexes to Chromatin  
46 The Jak/Stat Signaling Pathway
47 STAT3 Signaling Pathway  
48 PPAR Signaling Pathway  
49 New Formation of Nucleosomes  
50 New DNA Compaction into Chromosomes  
51 New Early Response Events to Moderate Double Strand Break (DSB) Levels  
52 New Cell Cycle Checkpoint and Double Strand Breaks (DSB)  
53 New Linkage Between DNA Repair and Chromatin Modification  
54 New Hypothetical Model on the Functions of the WRN, BLM and MRE11  
55 New mRNP Transport through the Nuclear Pore Complex (NPC)  
56 New Cargo Import by the Importinα-Importinβ Pathway  
57 New Modular Structure of Transcription Factors  
58 New Transcription Activation by Nuclear Receptors  
59 New Coupled RNA Splicing and Nuclear Export  
60 New RNA Polyadenylation  
61 New Mammalian mRNA Polyadenylation Machinery  
62 New RNA Maturation  
63 New RNA-guided Epigenetic Control of Gene Expression  
64 New Phosphorylation-driven Regulatory Switch from Transcription Initiation to Elongation  
back to top G PROTEINS AND CYCLIC NUCLEOTIDES  
65 Cyclic Nucleotide Metabolism - cAMP
66 Cyclic Nucleotide Metabolism - cGMP
67 Diversity of G-Protein-Coupled Receptor Signal Transduction Pathways  
back to top IMMUNE CELL SIGNALING AND BLOOD  
68 T Cell Receptor (TCR) Signaling
69 B Cell Receptor Complexes  
back to top ION CHANNELS  
70 Monovalent Ion Channels  
71 Activation and Inactivation of the Sodium Channel  
72 New Ligand-Gated Ion Channel: Structure and Activation Status  
73 New Aquaporin Channel Structure  
74 New Calcium Channel Structure  
75 New Calcium Channel Pore Region  
76 New Schematic Representation of the Chloride (CIC) Channel  
77 New Schematic Representation of the HCN Channel  
78 New 2TM Potassium Channel Structure  
79 New 6TM Potassium Channel Structure  
80 New Sodium Channel Structure  
81 New Sodium Channel Pore Region  
back to top LIPIDS IN CELL SIGNALING  
82 PTEN Pathway  
83 Lipids in Cell Signaling  
84 Inositol Phosphates  
85 Phosphatidic Acid Synthesis  
86 Signaling by Inositol Phospholipids  
back to top MULTI-DRUG RESISTANCE  
87 Mechanisms In Multi-drug Resistance: ABC-transporters and detoxification enzymes I hepatocytes  
88 ABC-ATPases as Regulatory Transporters for NHRs: chemical sensors for endogenous metabolites and xenobiotics  
89 Domain Organization of Bile Salt Transporter (BSEP)  
90 Domain Organization of Multi-drug Related Protein (MRP1)  
back to top NEUROBIOLOGY  
91 b-Amyloid Plaques  
back to top NEUROTRANSMISSION  
92 Second Messenger Systems Involved in Reward and Addiction  
93 Limbic Reward Circuit  
94 Major Noradrenergic, Dopaminergic and Serotonergic Pathways in the CNS  
95 Intracellular Signaling Pathways Activated by Endothelins  
96 NPY Inhibition of Catecholamine Release  
97 Ascending Pain Pathway  
98 Modulation of Pain Transmission  
99 Mechanism of Action of Selective Monoaminergic Reuptake Inhibitors. Figure A  
100 Mechanism of Action of Selective Monoaminergic Reuptake Inhibitors. Figure B  
101 Drug Activation of Dopaminergic Neurons  
102 Schematic Representation of the GABAB Receptor  
back to top NITRIC OXIDE AND CELL STRESS  
103 Oxidative Stress  
104 Neuronal Nitric Oxide Synthase (nNOS)  
105 Endothelial Nitric Oxide Synthase (eNOS)  
106 Inducible Nitric Oxide Synthase (iNOS)  
107 Nitric Oxide Metabolism  
108 Proteasome/Ubiquitination  
109 Formation of Activated 20S Proteasome  
110 Ubiquitin-Proteasome Pathway  
back to top PROTEIN PHOSPHORYLATION  
111 Mitogen-activated Protein Kinase Cascades
112 Akt Signaling  
113 Signaling Pathways Activated by VEGF  
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