PPAR Signaling Pathway

Similar to other nuclear hormone receptors, peroxisome proliferator-activated receptors (PPARs) act as ligand-activated transcription factors. When bound to its fatty acid ligand, PPARa forms a heterodimeric complex with the retinoid X receptor (RXR) to regulate transcription. PPARg is activated by prostaglandins and leukotrienes and regulates the gene expression of proteins involved in the storage of fatty acids. PARb is weakly activated by fatty acids, prostaglandins, and leukotrienes. Its physiological ligand has not been identified.

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References:

Fajas, L., et al., Peroxisome proliferator-activated receptor-g: from adipogenesis to carcinogenesis. J. Mol. Endocrinol., 27, 1-9 (2001).

Qi, C., et al., Peroxisome proliferator-activated receptors, coactivators, and downstream targets. Cell. Biochem. Biophys., 32, 187-204 (2000).