Schematic Representation of GABA_B Receptor

Representation of the GABA_B receptor heterodimer which is composed of two, seven transmembrane-spanning units that are linked by their carboxyl-termini. The apparent ligand binding domains are on the extracellular surface of R1 and R2. Activation of the heterodimer modulates adenyl cyclase activity via G-proteins that, in addition, influence K⁺ and Ca²⁺ conductance.

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References

Marshall, F.H., et al., GABA_B receptors - the first 7TM heterodimers. Trends Pharmacol. Sci., 20, 396-399 (1999).

Couve, A., et al., GABA_B receptors : a new paradigm in G protein signaling. Mol. Cell. Neurosci., 16, 296-312 (2000).