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Gene Editing & Functional Genomics

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Sigma-Aldrich® Advanced Genomics offers a complete suite of genome engineering and modulation products and services. Our comprehensive portfolio delivers support for every step of your research, from discovery through translational research to therapeutic impact.  

Target a single gene or screen a whole genome with fully customizable products. With tools to edit using CRISPR or ZFNs, modulate expression with CRISPRa/i or RNAi, or perform whole genome screens, you’re limited only by your scientific curiosity. And with over 350 years of technical leadership, Sigma-Aldrich® Advanced Genomics offers an unsurpassed breadth of expertise and intellectual property to help you succeed.

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CRISPR & Gene Editing

CRISPR & Gene Editing

With decades of gene editing experience and an unsurpassed portfolio of CRISPR and ZFN technology patents, Sigma-Aldrich® Advanced Genomics delivers the highest quality reagents for your entire workflow, from early-stage discovery to translational research. Whether you are looking to knockout, knock-in, knockdown, or overexpress your targets, our comprehensive suite of CRISPR gene-editing tools and services will take your research Beyond the Bench.

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RNAi Single Clones

Sigma-Aldrich® Advanced Genomics RNAi Single Clones deliver powerful, long term, and stable gene silencing. As an exclusive provider of the TRC1.5 and TRC2 collections from The RNAi Consortium (TRC), our comprehensive offering consists of nearly 200,000 pre-cloned shRNA constructs targeting more than 22,500 human and 20,000 mouse genes.

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RNAi Single Clones

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Genetic Screening

Sigma-Aldrich® Advanced Genomics offers complete solutions for your genetic screens at any scale. Whether you're targeting specific genes or performing a genome-wide screen, we offer extensive pooled and arrayed formats to meet your needs. From gene expression knockdown with CRISPRi and RNAi to overexpression with CRISPRa and ORF, we have everything you need for your target discovery research.

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The image presents a close-up view of virus particles, with a dominant golden particle in the center, characterized by its spherical shape and numerous spike proteins. The background features additional particles in golden-yellow and blue hues, all set against a blurred backdrop that accentuates the central figure and adds depth to the composition. The image captures the intricate details and diversity of virus particles, highlighting their unique structures.
RNAi Libraries

Sigma-Aldrich® Advanced Genomics is the exclusive provider of the TRC1.5 and TRC2 collections from The RNAi Consortium (TRC). These lentivirus-based shRNA libraries deliver unparalleled coverage and are available in multiple formats that include whole-genome, individual RNAi clones/vectors, and gene family sets. Available in standard glycerol format or higher quality DNA and lentiviral formats.

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Custom & Predesigned RNA Oligos, siRNA Duplexes and Controls

A comprehensive portfolio of custom & predesigned RNA oligos, miRNAs, esiRNAs, and siRNA duplexes and controls, available with modification options in multiple formats comply with ISO 9001 and ISO 13485 quality systems for research and commercial applications.

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Product Number
Product Name
Product Description
Pricing
SHCLNG
MISSION® shRNA
Bacterial Stock
SHCLNV
MISSION® shRNA
Lentiviral Particles
SHCLND
MISSION® shRNA
Purified DNA
CAS9GFPPRO
Cas9-GFP Protein
from Streptococcus pyogenes, fused with enhanced GFP, recombinant, expressed in E. coli, 3X NLS
SHP001
MISSION® Lentiviral Packaging Mix
Production of replication incompetent viral particles
CAS9PROT
Cas9 Protein
from Streptococcus pyogenes, recombinant, expressed in E. coli, 1X NLS
SITRAN-RO
X-tremeGENE™ siRNA Transfection Reagent
Polymer reagent for delivering siRNA to common cell lines
SHC001
MISSION® pLKO.1-puro Empty Vector Control Plasmid DNA
Contains no shRNA insert
SHC016
MISSION® pLKO.1-puro Non-Target shRNA Control Plasmid DNA
Targets no known genes from any species
SHC002
MISSION® pLKO.1-puro Non-Mammalian shRNA Control Plasmid DNA
Targets no known mammalian genes
DCAS9PROT
dCas9-3XFLAG™-Biotin Protein
from Streptococcus pyogenes with D10A and H840A mutations, recombinant, expressed in E. coli, 1X NLS
SHC016V
MISSION® pLKO.1-puro Non-Target shRNA Control Transduction Particles
Targets no known genes from any species
SHC003
MISSION® pLKO.1-puro-CMV-TurboGFP™ Positive Control Plasmid DNA
Green fluorescent protein marker to monitor transduction efficiency
SHC002V
MISSION® pLKO.1-puro Non-Mammalian shRNA Control Transduction Particles
Targets no known mammalian genes
CAS9GFPP
CMV-CAS9-2A-GFP Plasmid
CAS9D10APR
Cas9-D10A Nickase Protein
from Streptococcus pyogenes with D10A mutation, recombinant, expressed in E. coli, 1X NLS
ECAS9GFPPR
eSpCas9-GFP Protein
from Streptococcus pyogenes with mutations conferring enhanced specificity, fused with enhanced GFP, recombinant, expressed in E. coli, 3X NLS
CSTVRS
MISSION® shRNA
Custom Lentiviral Particles
CAS9P
Cas9 plasmid
SHC201
MISSION® TRC2 pLKO.5-puro Empty Vector Control Plasmid DNA
Contains no shRNA insert
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