Sigma-Aldrich is proud to provide innovative solutions for academic research and pharmaceutical drug discovery. Our excellent systems, equipment and personnel provide the high quality tools you require.
The dedicated MISSION™ RNAi R&D and manufacturing facilities are housed in the new Sigma-Aldrich Life Science and High Technology Center in St. Louis, MO, USA. The R&D and manufacturing personnel consist of scientists with a wide array of experience in molecular biology, RNAi, clone handling and bioinformatics.
MISSION™ RNAi products are manufactured with state-of-the art robotics and laboratory inventory management systems (LIMS). The shRNA libraries are housed in BIOPHILE™ robotic -80 °C frost-free freezers. Every clone is managed from individual 2D barcoded tubes in 1D barcoded racks providing the ultimate reliability in clone handling. Therefore, manipulation (storage, handling, manufacturing and QC) of every clone is tracked via the LIMS system. Re-arrays of every library, gene panel, and customer order is performed within the enclosed robotic -80°C frost free freezers to ensure quality of the collection. The manufacturing facilities also utilize 2D and 1D barcode scanners and dedicated personnel and robotic liquid handlers for each product format (glycerol, purified DNA, and viral particles). Viral particle manufacturing robotics are enclosed within biosafety cabinets in BSL2 cell culture laboratories for optimal cell culture environment and viral production.
Life Science and High Technology Center
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Exterior view of center
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Interior view of atrium |
The Life Science and High Technology Center is known for both state-of-the-art laboratories as well as providing a stimulating environment designed to facilitate interaction among the scientists. |
 Analytical laboratories house sequencing services used in QC of MISSION collections |
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BIOPHILE™ -80 °C Frost Free Robotic Freezers
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View of a BIOPHILE station
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MISSION TRC clones are housed in robotic freezers that store and re-rack clones via 2D barcoded tubes, 1D barcoded racks, robotic arms, enclosed conveyer belts between units, scanners, and computer/LIMS interface. |
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Barcode Handling of Clones
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2D barcodes on 96-tube arrays |
Barcode scanner output
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Robotic Liquid Handlers
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 View of an enclosed viral production liquid handler |
High-Throughput Lentiviral Particle Production Results
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Contact Us
For questions about the library, pricing and quotes or other concerns, please e-mail us at: RNAi@sial.com.
MISSION is a registered trademark of Sigma-Aldrich Biotechnology LP and Sigma-Aldrich Co. Label License.
BIOPHILE is a trademark of TekCel.
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