Listed below are many of the top research articles relevant to RNAi and Functional Genomics research. Articles include shRNA, lentiviral-based systems, delivery to various cell lines and transgenic animals, as well as reviews on siRNA. All references are linked to PubMed, where you can find complete abstract information and relevant journal information.
If you would like a particular reference added to the current bibliography, please email us at biotechsolutions@sial.com. If we are able, we will add it to the list.
| Basic Mechanism |
| Title |
Author / Journal |
Abstract |
| The silent treatment: RNAi as a defense against virus infection in mammals. |
van Rij RP, Andino R.
Trends Biotechnol. 2006. Apr;24(4):186-93. Epub 2006. Feb 28.
|
abstract |
| A Facile Lentiviral Vector System for Expression of Doxycycline-Inducible shRNAs: Knockdown of the Pre-miRNA Processing Enzyme Drosha. |
Aagaard L, et al.
Mol Ther. 2007. Feb 20.
|
abstract |
| RNA interference has a role in regulating Drosophila telomeres. |
Casacuberta E, Pardue ML. Perrimon.
Genome Biol. 2006. 7(5):220. Epub 2006 May 31. Review.
|
abstract |
| Is RNA interference involved in intrinsic antiviral immunity in mammals? |
Cullen BR.
Nat. Immunol. 2006. June; 7(6):563-7. Review.
|
abstract |
| Gene silencing of virus replication by RNA interference. |
Miyano-Kurosaki N, Takaku H.
Handb Exp Pharmacol. 2006;(173):151-71. |
abstract |
| Exploring the functions of RNA interference pathway proteins: some functions are more RISCy than others? |
Jaronczyk K, Carmichael JB, Hobman TC.
Biochem. J.. 2005 May 1;387(Pt 3):561-71. |
abstract |
| Viral delivery of recombinant short hairpin RNAs. |
Davidson BL, Harper SQ.
Methods Enzymol. 2005;392:145-73 |
abstract |
| Paradigms for conditional expression of RNA interference molecules for use against viral targets. |
Strayer DS, Feitelson M., Sun B., Matskevich AA.
Methods Enzymol. 2005;392:227-41 |
abstract |
| Small RNA asymmetry in RNAi: function in RISC assembly and gene regulation. |
Hutvagner G.
FEBS Lett. 2005 Oct 31;579(26):5850-7 |
abstract |
| Uncovering RNAi mechanisms in plants: biochemistry enters the foray. |
Qi Y, Hannon GJ.
FEBS Lett. 2005 Oct 31;579(26):5899-903 |
abstract |
| Plant pathology and RNAi: a brief history. |
Lindbo JA, Dougherty WG.
Annu Rev Phytopathol. 2005;43:191-204 |
abstract |
| RNAi: the nuts and bolts of the RISC machine. |
Filipowicz W.
Cell. 2005 Jul 15;122(1):17-20 |
abstract |
| Molecular mechanisms of RNAi: implications for development and disease. |
Rao M, Sockanathan S.
Birth Defects Res C Embryo Today. 2005 Mar;75(1):28-42 |
abstract |
| RNAi-mediated pathways in the nucleus. |
Matzke MA, Birchler JA.
Nat Rev Genet. 2005 Jan;6(1):24-35 |
abstract |
| Dicing and slicing: the core machinery of the RNA interference pathway. |
Hammond SM.
FEBS Lett. 2005 Oct 31;579(26):5822-9 |
abstract |
| RNA interference, transposon silencing, and cosuppression in the Caenorhabditis elegans germ line: similarities and differences. |
Robert VJ, Vastenhouw NL, Plasterk RH.
Cold Spring Harb Symp Quant Biol. 2004;69:397-402 |
abstract |
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| High-Throughput Screening |
| Title |
Author / Journal |
Abstract |
| Drug-target identification in Drosophila cells: combining high-throughout RNAi and small-molecule screens. |
Perrimon N, Friedman A, Mathey-Prevot B, Eggert US.
Drug Discov Today. 2007 Jan;12(1-2):28-33. Epub 2006 Oct 30
|
abstract |
| MDR1/P-glycoprotein (ABCB1) as target for RNA interference-mediated reversal of multidrug resistance. |
Lage H.
Curr Drug Targets. 2006. Jul; 7(7):813-21. Review.
|
abstract |
| High-throughput RNAi Screening in Cultured Cells: A User's Guide.
|
Echeverri, C. and N. Perrimon.
Nature Reviews Genetics. 2006. 7, 373-384.
|
abstract |
| From genome to phenome--RNAi library screening and hit characterization using signaling pathway analysis. |
Chatterjee-Kishore M.
Curr Opin Drug Discov Devel. 2006 Mar;9(2):231-9. |
abstract |
| High-throughput RNA interference in functional genomics |
Janitz M, Vanhecke D, Lehrach H.
Handb Exp Pharmacol. 2006;(173):97-104. |
abstract |
| Exploring the sounds of silence: RNAi-mediated gene silencing for target identification and validation. |
Chatterjee-Kishore M, Miller CP.
Drug Discov Today. 2005 Nov 15;10(22):1559-65 |
abstract |
| Genome-wide application of RNAi to the discovery of potential drug targets. |
Ito M, Kawano K, Miyagishi M, Taira K.
FEBS Lett. 2005 Oct 31;579(26):5988-95 |
abstract |
| Genome-wide screening for gene function using RNAi in mammalian cells. |
Cullen LM, Arndt GM.
Immunol Cell Biol. 2005 Jun;83(3):217-23 |
abstract |
| RNAi and HTS: exploring cancer by systematic loss-of-function. |
Willingham AT, Deveraux QL, Hampton GM, Aza-Blanc P.
Oncogene. 2004 Nov 1;23(51):8392-400 |
abstract |
| Oncology studies using siRNA libraries: the dawn of RNAi-based genomics. |
Sachse C, Echeverri CJ.
Oncogene. 2004 Nov 1;23(51):8384-91 |
abstract |
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| In Vivo Applications |
| Title |
Author / Journal |
Abstract |
| Downregulation of mu opioid receptor by RNA interference in the ventral tegmental area reduces ethanol consumption in mice. |
Lasek AW, Janak PH, He L, Whistler JL, Heberlein U.
Genes Brain Behav. 2007. Mar 26.
|
abstract |
| Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis. |
Shaw AT, et al.
Genes Dev. 2007. Mar 15;21(6):694-707.
|
abstract |
| In Vivo Gene Transfer into Adult Stem Cells in Unconditioned Mice by in Situ Delivery of a Lentiviral Vector. |
Worsham DN, Schuesler T, von Kalle C, Pan D.
Mol Ther. 2006. Aug; 4; [Epub ahead of print].
|
abstract |
| RNA interference-mediated prevention and therapy for hepatocellular carcinoma. |
Romano PR, McCallus DE, Pachuk CJ.
Oncogene. 2006. Jun 26; 25(27): 3857-65. Review.
|
abstract |
| Gene silencing through RNA interference (RNAi) in vivo: strategies based on the direct application of siRNAs. |
Aigner A.
J Biotechnology. 2006. Jun 25; 124(1): 12-25. Epub 2006 Jan 18. Review.
|
abstract |
| Therapeutic potential of RNAi in metabolic diseases.
|
Rondinone CM.
Biotechniques. 2006 Apr; Suppl:31-6. Review.
|
abstract |
| RNAi as a treatment for HIV-1 infection. |
Rossi JJ.
Biotechniques. 2006 Apr; Suppl:25-9. Review. |
abstract |
| Antiviral applications of RNAi. |
Morris KV, Rossi JJ.
Curr Opin Mol Ther. 2006 Apr; 8(2):115-21. Review. |
abstract |
| Antiviral applications of RNAi. |
Morris KV, Rossi JJ.
Handb Exp Pharmacol. 2006;(173):105-16 |
abstract |
| RNAi as an antiviral therapy. |
Bagasra O.
Expert Opin Biol Ther. 2005 Nov;5(11):1463-74. Review. |
abstract |
| A single administration of lentiviral vectors expressing either full-length human immunodeficiency virus 1
(HIV-1)HXB2 Rev/Env or codon-optimized HIV-1JR-FL gp120 generates durable immune responses in
mice. |
Buffa V, Negri DR, Leone P, Bona R, Borghi M, Bacigalupo I, Carlei D, Sgadari C, Ensoli B, Cara A.
J Gen Virol. . 2006 Jun;87(Pt 6):1625-34. |
abstract |
| In Vivo Transduction by Intravenous Injection of a Lentiviral Vector Expressing Human ADA into Neonatal ADA Gene Knockout Mice: A Novel Form of Enzyme Replacement Therapy for ADA Deficiency. |
Carbonaro DA, Jin X, Petersen D, Wang X, Dorey F, Kil KS, Aldrich M, Blackburn MR, Kellems RE, Kohn DB.
Mol Ther. 2006 Apr 29; [Epub ahead of print] |
abstract |
| RNA interference: a potential therapeutic tool for silencing splice isoforms linked to human diseases. |
Gaur RK.
Biotechniques. 2006 Apr;Suppl:15-22. Review. |
abstract |
| Potential applications of RNA interference technology in the treatment of cancer. |
Lage H.
Future Oncol. 2005 Feb;1(1):103-13. Review. |
abstract |
| RNA interference for treating haematological malignancies. |
Hexner EO, Gewirtz AM.
Expert Opin Biol Ther. 2005 Dec;5(12):1585-92. Review. |
abstract |
| RNA interference: its use as antiviral therapy. |
Haasnoot J, Berkhout B.
Handb Exp Pharmacol. 2006;(173):117-50. |
abstract |
| RNA interference in cancer. |
Gartel AL, Kandel ES.
Biomol Eng. 2006 Mar;23(1):17-34. Epub 2006 Feb 8. |
abstract |
| RNA interference as a potential tool in the treatment of leukaemia. |
Borkhardt A, Heidenreich O.
Expert Opin Biol Ther. 2004 Dec;4(12):1921-9. |
abstract |
| Clearance of hepatitis B virus from the liver of transgenic mice by short hairpin RNAs. |
Uprichard S., Boyd B., Althage A., Chisari F.
Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):773-8 |
abstract |
| Stable inhibition of hepatitis B virus proteins by small interfering RNA expressed from viral vectors. |
Moore M., McGarvey M., Russell R., Cullen B., McClure M.
J Gene Med. 2005 Jul;7(7):918-25 |
abstract |
| RNAi as an antiviral therapy. |
Bagasra, Omar
Expert Opin Biol Ther. 2005 Nov;5(11):1463-74 |
abstract |
| Silencing viruses by RNA interference. |
Colboere-Garapin F., Blondel B., Saulnier A., Pelletier I., Labadie K.
Microbes Infect.
2005 Apr;7(4):767-75 |
abstract |
| Biology calls the targets: combining RNAi and disease biology. |
van Es HH, Arts GJ.
Drug Discov Today. 2005 Oct 15;10(20):1385-91. Review. |
abstract |
| State-of-the-art modified RNAi compounds for therapeutics. |
Carstea ED, Hough S, Wiederholt K, Welch PJ.
IDrugs. 2005 Aug;8(8):642-7 |
abstract |
| Progress toward the therapy of hepatitis with RNAi. |
Rendall G.
Hepatology. 2005 Jun;41(6):1220-2 |
abstract |
| RNAi, a new therapeutic strategy against viral infection. |
Tan FL, Yin JQ.
Cell Res. 2004 Dec;14(6):460-6 |
abstract |
| Challenges for RNAi in vivo. |
Paroo Z, Corey DR.
Trends Biotechnol. 2004 Aug;22(8):390-4 |
abstract |
| RNAi knock-down mice: an emerging technology for post-genomic functional genetics. |
Prawitt D, Brixel L, Spangenberg C, Eshkind L, Heck R, Oesch F, Zabel B, Bockamp
E.
Cytogenet Genome Res. 2004;105(2-4):412-21 |
abstract |
| RNA interference-based gene silencing in mice: the development of a novel therapeutical strategy. |
Spankuch B, Strebhardt K.
Curr Pharm Des. 2005;11(26):3405-19 |
abstract |
| Delivering RNA interference to the mammalian brain. |
Fountaine TM, Wood MJ, Wade-Martins R.
Curr Gene Ther. 2005 Aug;5(4):399-410 |
abstract |
| In vivo application of RNA interference: from functional genomics to therapeutics. |
Lu PY, Xie F, Woodle MC.
Adv Genet. 2005;54:117-42 |
abstract |
| Silencing viruses by RNA interference. |
Colbere-Garapin F, Blondel B, Saulnier A, Pelletier I, Labadie K.
Microbes Infect. 2005 Apr;7(4):767-75 |
abstract
|
| RNA interference & inhibition of viruses. |
Gadkari, DA.
Indian J Med Res. 2005 Mar;121(3):147-50 |
abstract |
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| In Vivo Disease Treatment |
| Title |
Author / Journal |
Abstract |
| Safety and Efficacy of a Lentiviral Vector Containing Three Anti-HIV Genes-CCR5 Ribozyme, Tat-rev siRNA, and TAR Decoy-in SCID-hu Mouse-Derived T Cells. |
Anderson J, Li MJ, Palmer B, Remling L, Li S, Yam P, Yee JK, Rossi J, Zaia J, Akkina R.
Mol Ther. 2007. Apr 3.
|
abstract |
| Lentiviral vector-mediated genetic modification of human neural progenitor cells for ex vivo gene therapy. |
Capowski EE, Schneider BL, Ebert AD, Seehus CR, Szulc J, Zufferey R, Aebischer P, Svendsen CN.
J Neurosci Methods. 2007. Mar 3.
|
abstract |
| Targeted transgene expression in muller glia of normal and diseased retinas using lentiviral vectors. |
Greenberg KP, et al.
Invest Ophthalmol Vis Sci. 2007. Apr;48(4):1844-52.
|
abstract |
| Target validation using RNA interference in solid tumors. |
Aharinejad S, et al.
Methods Mol Biol. 2007;361:227-38. Review.
|
abstract |
| Gene delivery to airway epithelial cells in vivo: a direct comparison of apical and basolateral transduction strategies using pseudotyped lentivirus vectors. |
Kremer KL, et al.
J Gene Med. 2007. Mar 22.
|
abstract |
| RNAi therapy for neurodegenerative diseases. |
Boudreau RL, Davidson BL
Curr Top Dev Biol. 2006. 75: 73-92. Review.
|
abstract |
| Interference RNA technology in the treatment of CNV. |
Tolentino M
Ophthalmol Clin North Am. 2006. Sep; 19(3): 393-9, vi-vii. Review.
|
abstract |
| RNA interference: a potential revolution in disease therapy. |
Waseem T.
J Coll Physicians Surg Pak. 2006. Jul; 16(7): 491-2. Review.
|
abstract |
| Correction of Cardiac Abnormalities in Fabry Mice by Direct Intraventricular Injection of a Recombinant Lentiviral Vector that Engineers Expression of alpha-Galactosidase A. |
Yoshimitsu M, Higuchi K, Dawood F, Rasaiah VI, Ayach B, Chen M, Liu P, Medin JA.
Circ J. 2006. Nov; 70(11): 1503-8.
|
abstract |
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| Broad Publications |
| Title |
Author / Journal |
Abstract |
| Integrative genomic approaches identify IKBKE as a breast cancer oncogene. |
Boehm, J. S. et al.
Cell 2007. 129: 1065-1079. |
abstract |
| Wild-type NRas and KRas perform distinct functions during transformation. |
Fotiadou, P. P., Takahashi, C., Rajabi, H. N., Ewen, M. E.
Mol. Cell. Biol. 2007. 27: 6742-6755. |
abstract |
| Comparative oncogenomics identifies NEDD9 as a melanoma metastasis gene. |
Kim, M. et al.
Cell 2006. 125: 1269-1281. |
abstract |
| A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen. |
Moffat, J. et al.
Cell 2006. 124: 1283-1298. |
abstract |
| PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase. |
Sancak, Y. et al.
Mol. Cell 2007. 25: 903-915. |
abstract |
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| MISSION® shRNA Publications |
| Title |
Author / Journal |
Abstract |
| Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit. |
Binne, U. K. et al.
Nat. Cell Biol. 2007. 9: 225-232. |
abstract |
| BCL2 is a downstream effector of MIZ-1 essential for blocking c-MYC-induced apoptosis. |
Patel, J. H., McMahon, S. B.
J. Biol. Chem. 2007. 282: 5-13. |
abstract |
| Genome-scale loss-of-function screening with a lentiviral RNAi library. |
Root, D. E., Hacohen, N., Hahn, W. C., Lander, E. S., Sabatini, D. M.
Nat. Methods 2006. 3: 715-719. |
abstract |
| EphB-ephrin-B interactions suppress colorectal cancer progression by compartmentalizing tumor cells. |
Cortina, C. et al.
Nat. Genet. 2007. 39: 1376-1383. |
abstract |
| The homeobox gene CDX2 is aberrantly expressed in most cases of acute myeloid leukemia and promotes leukemogenesis. |
Scholl, C. et al.
J Clin Invest 2007. 117: 1037-1048. |
abstract |
| Genome-wide application of RNAi to the discovery of potential drug targets. |
Ito, M., Kawano, K., Miyagishi, M., Taira, K.
FEBS Lett. 2005. 579: 5988-5995. |
abstract |
| Targeting of FAK Ser910 by ERK5 and PP1delta in non-stimulated and phorbol ester-stimulated cells. |
Villa-Moruzzi, E.
Biochem. J. 2007. 408: 7-18. |
abstract |
| Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40. |
Vander Haar, E., Lee, S. I., Bandhakavi, S., Griffin, T. J., Kim, D. H.
Nat. Cell Biol. 2007. 9: 316-323. |
abstract |
| Widespread microRNA repression by Myc contributes to tumorigenesis. |
Chang, T. C. et al.
Nat. Genet. 2008. 40: 43-50. |
abstract |
| Akt attenuation of the serine protease activity of HtrA2/Omi through phosphorylation of serine 212. |
Yang, L. et al.
J. Biol. Chem. 2007. 282: 10981-10987. |
abstract |
| Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma. |
Bar, E. E.
Stem Cells 2007. 25: 2524-2533. |
abstract |
| Identification of yin-yang regulators and a phosphorylation consensus for male germ cell-associated kinase (MAK)-related kinase. |
Fu, Z. et al.
Mol. Cell. Biol. 2006. 26: 8639-8654. |
abstract |
| Regulation of interleukin-6-induced hepatic insulin resistance by mammalian target of rapamycin through the STAT3-SOCS3 pathway. |
Kim, J. H., Kim, J. E., Liu, H. Y., Cao, W., Chen, J.
J. Biol. Chem. 2008. 283: 708-715. |
abstract |
| A Sensitive Flow Cytometry-based Nucleotide Excision Repair Assay Unexpectedly Reveals That Mitogen-activated Protein Kinase Signaling Does Not Regulate the Removal of UV-induced DNA Damage in Human Cells. |
Rouget, R., Auclair, Y., Loignon, M., Affar el, B., Drobetsky, E. A.
J. Biol. Chem. 2008. 283: 5533-5541. |
abstract |
| Epigenetic silencing of O6-methylguanine-DNA methyltransferase gene in NiS-transformed cells. |
Ji, W. et al.
Carcinogenesis 2008. |
abstract |
| Coactivation of janus tyrosine kinase (Jak)1 positively modulates prolactin-Jak2 signaling in breast cancer: recruitment of ERK and signal transducer and activator of transcription (Stat)3 and enhancement of Akt and Stat5a/b pathways. |
Neilson, L. M. et al.
Mol. Endocrinol. 2007. 21: 2218-2232. |
abstract |
| Glucocorticoids regulate tristetraprolin synthesis and posttranscriptionally regulate tumor necrosis factor alpha inflammatory signaling. |
Smoak, K., Cidlowski, J. A.
Mol. Cell. Biol. 2006. 26: 9126-9135. |
abstract |
| GATA-6 mediates human bladder smooth muscle differentiation: involvement of a novel enhancer element in regulating alpha-smooth muscle actin gene expression. |
Kanematsu, A., Ramachandran, A., Adam, R.M.
Am. J. Physiol. Cell. Physiol. 2007. 294: C1093-1102. |
abstract |
| c-myc Repression of TSC2 contributes to control of translation initiation and Myc-induced transformation. |
Ravitz, M. J., Chen, L., Lynch, M., Schmidt, E. V.
Cancer Res. 207. 67: 11209-11217. |
abstract |
| Identification and characterization of putative tumor suppressor NGB, a GTP-binding protein that interacts with the neurofibromatosis 2 protein. |
Lee, H. et al.
Mol. Cell. Biol. 2007. 27: 2103-2119. |
abstract |
| Interferon regulatory factors are transcriptional regulators of adipogenesis. |
Eguchi, J. et al.
Cell. Metab. 2008. 7: 86-94. |
abstract |
| Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis. |
Dai, C., Whitesell, L., Rogers, A. B., Lindquist, S.
Cell 2007. 130: 1005-1018. |
abstract |
| TTF-1 regulates growth hormone and prolactin transcription in the anterior pituitary gland. |
Lee, N. O. et al.
Biochem. Biophys. Res. Commun. 2007. 362: 193-199. |
abstract |
| Lentivirus-delivered stable gene silencing by RNAi in primary cells. |
Stewart, S. A. et al.
RNA 2003. 9: 493-501. |
abstract |
| Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis. |
Yousefi, S. et al.
Nat. Cell. Biol. 2006. 8: 1124-1132. |
abstract |
| Acetylation of the p53 DNA-binding domain regulates apoptosis induction. |
Sykes, S. M. et al.
Mol. Cell 2006. 24: 841-851. |
abstract |
| Control of AMPK-related kinases by USP9X and atypical Lys29/Lys33-linked polyubiquitin chains. |
Al-Hakim, A. K. et al.
Biochem. J. 2008. |
abstract |
| Expression of SMARCB1 modulates steroid sensitivity in human lymphoblastoid cells: identification of a promoter SNP that alters PARP1 binding and SMARCB1 expression. |
Pottier, N. et al.
Hum. Mol. Genet. 2007. 16: 2261-2271. |
abstract |
| The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression. |
Zhang, X. Y. et al.
Mol. Cell 2008. 29: 102-111. |
abstract |
| Protein phosphatase 2A subunit PR70 interacts with pRb and mediates its dephosphorylation. |
Magenta, A. et al.
Mol. Cell. Biol. 2008. 28: 873-882. |
abstract |
| Repression of PTEN phosphatase by Snail1 transcriptional factor during gamma radiation-induced apoptosis. |
Escriva, M. et al.
Mol. Cell. Biol. 2008. 28: 1528-1540. |
abstract |
| Non-classical export of epimorphin and its adhesion to alphav-integrin in regulation of epithelial morphogenesis. |
Hirai, Y. et al.
J. Cell Sci. 2007. 120: 2032-2043. |
abstract |
| Functional genomic analysis reveals cross-talk between peroxisome proliferator-activated receptor gamma and calcium signaling in human colorectal cancer cells. |
Bush, C. R. et al.
J. Biol. Chem. 2007. 282: 23387-23401. |
abstract |
| Lipopolysaccharide-mediated interferon regulatory factor activation involves TBK1-IKKepsilon-dependent Lys(63)-linked polyubiquitination and phosphorylation of TANK/I-TRAF. |
Gatot, J. S. et al.
J. Biol. Chem. 2007. 282: 31131-31146. |
abstract |
| The death-associated protein kinase 2 is up-regulated during normal myeloid differentiation and enhances neutrophil maturation in myeloid leukemic cells. |
Rizzi, M. et al.
J. Leukocyte Biol. 2007. 81: 1599-1608. |
abstract |
| Heparan sulfate Ndst1 gene function variably regulates multiple signaling pathways during mouse development. |
Pallerla, S. R., Pan, Y., Zhang, X., Esko, J. D., Grobe, K.
Dev. Dyn. 2007. 236: 556-563. |
abstract |
| Characterization of the intracellular proteolytic cleavage of myocilin and identification of calpain II as a myocilin-processing protease. |
Sanchez-Sanchez, F., Martinez-Redondo, F., Aroca-Aguilar, J. D., Coca-Prados, M., Escribano, J.
J. Biol. Chem. 2007. 282: 27810-27824. |
abstract |
| Inhibition of RAS-mediated transformation and tumorigenesis by targeting the downstream E3 ubiquitin ligase seven in absentia homologue. |
Schmidt, R. L. et al.
Cancer Res. 2007. 67: 11798-11810. |
abstract |
| A screen of shRNAs targeting tumor suppressor genes to identify factors involved in A549 paclitaxel sensitivity. |
Ji, D., Deeds, S. L., Weinstein, E. J.
Oncol. Rep. 2007. 18: 1499-1505. |
abstract |
| PML contributes to a cellular mechanism of repression of herpes simplex virus type 1 infection that is inactivated by ICP0. |
Everett, R. D. et al.
J. Virol. 2006. 80: 7995-8005. |
abstract |
| HMGA1 is a determinant of cellular invasiveness and in vivo metastatic potential in pancreatic adenocarcinoma. |
Liau, S. S., Jazag, A., Whang, E. E.
Cancer Res. 2006. 66: 11613-11622. |
abstract |
| Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression. |
Takeda, S. et al.
Genes Dev. 2006. 20: 2397-2409. |
abstract |
| Lentivirus-mediated RNA interference of HMGA1 promotes chemosensitivity to gemcitabine in pancreatic adenocarcinoma. |
Liau, S. S., Ashley, S. W., Whang, E. E.
J. Gastrointest. Surg. 2006. 10: 1254-1262; discussion 1263. |
abstract |
| Overexpression of HMGA1 promotes anoikis resistance and constitutive Akt activation in pancreatic adenocarcinoma cells. |
Liau, S. S., Jazag, A., Ito, K., Whang, E. E.
Br. J. Cancer 2007. 96: 993-1000. |
abstract |
| Telomere protection mechanisms change during neurogenesis and neuronal maturation: newly generated neurons are hypersensitive to telomere and DNA damage. |
Cheng, A. et al.
J. Neurosci. 2007. 27: 3722-3733. |
abstract |
| cFLIPL prevents TRAIL-induced apoptosis of hepatocellular carcinoma cells by inhibiting the lysosomal pathway of apoptosis. |
Guicciardi, M. E., Bronk, S. F., Werneburg, N. W. Gores, G. J.
Am. J. Physiol. Gastrointest. Liver Physiol. 2007. 292: G1337-1346. |
abstract |
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| Specific Applications |
| Title |
Author / Journal |
Abstract |
| beta Cell cytoprotection using lentiviral vector-based iNOS-specific shRNA delivery. |
McCabe C, O'Brien T.
Biochem. Biophys. Res. Commun.. 2007 May 25;357(1):75-80. Epub 2007 Mar 28. |
abstract |
| Trophoblast-specific gene manipulation using lentivirus-based vectors. |
Georgiades P, et al.
Biotechniques. 2007. Mar;42(3):317-8, 320, 322-5. |
abstract |
| Suppression of PPAR{gamma} Attenuates Insulin-Stimulated Glucose Uptake by Affecting Both GLUT1 and GLUT4 in 3T3-L1 Adipocytes. |
Liao W, et al.
Am J Physiol Endocrinol Metab. . 2007. Mar 27 |
abstract |
| CKS1B, over expressed in aggressive disease, regulates multiple myeloma growth and survival through SKP2- and p27Kip1-dependent and independent mechanisms. |
Zhan F, et al.
Blood. 2007. Feb 15.
|
abstract |
| VEGF-induced heme oxygenase-1 confers cytoprotection from lethal hyperoxia in vivo |
Siner JM, et al.
FASEB J. 2007. Jan 30.
|
abstract |
| Regulating MHC expression for cellular therapeutics. |
Figueiredo C, et al.
Transfusion. 2007. Jan; 47(1):18-27.
|
abstract |
| Identification of cell-type-specific promoters within the brain using lentiviral vectors. |
Chhatwal JP, et al.
Gene Ther. 2007. Jan 18.
|
abstract |
| Lentiviral and Murine Retroviral Transduction of T Cells for Expression of Human CD40 Ligand. |
Simon, C. Barry, J. Seppen, N. Ramesh, J.L. Foster, K. Seyama, H.D. Ochs, J.V. Garcia, W.R.A. Osborne
Human Gene Therapy. 2000. Jan; 11; (2): 323-332.
|
abstract |
| Lentiviral manipulation of gene expression in human adult and embryonic stem cells. |
Clements MO, Godfrey A, Crossley J, Wilson SJ, Takeuchi Y, Boshoff C.
Tissue Eng. 2006. Jul; 12; (7): 1741-51.
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abstract |
| RNA interference pinpoints regulators of cell size and the cell cycle. |
Cully MJ, Leevers SJ
Genome Biol. 2006. 7(5): 219. Epub 2006 May 30. Review
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abstract |
| Building mammalian signalling pathways with RNAi screens. |
Moffat J, Sabatini DM.
Nat Rev Mol. Cell. Biol.. 2006 Mar;7(3):177-87. Review. |
abstract |
| Lentivirus vector gene expression during ES cell-derived hematopoietic development in vitro. |
Hamaguchi I, et al.
J. Virology. (2000) Vol.74 pp.10778-10784. |
abstract |
| Application of lentivirus-mediated RNAi in studying gene function in mammalian tooth development. |
Song Y, et al.
Dev. Dyn.. 2006 Apr 20;235(5):1347-1357 |
abstract |
| Inhibition of hepatitis B virus surface antigen expression by small hairpin RNA in vitro. |
Yang ZG., Chen Z., Ni Q., Xu N., Shao JB., Yao HP.
World J Gastroenterol. 2005 Jan 28;11(4):498-502 |
abstract |
| Inhibition of hepatitis B virus gene expression by single and dual small interfering RNA treatment. |
Wu KL, Zhang X., Zhang J., Yang Y., Mu YX, Liu M., Lu L., Li, Y., Zhu Y., Wu J.
Virus
Res. 2005 Sep;112(1-2):100-7 |
abstract |
| Application of RNA interference to study stem cell function: current status and future perspectives. |
Zou GM, Yoder MC.
Biol Cell. 2005 Mar;97(3):211-9 |
abstract
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| Exploiting the RNA interference pathway to counter hepatitis B virus replication. |
Arbuthnot P., Carmona S., Ely A.
Liver Int. 2005 Feb;25(1):9-15 |
abstract |
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| Assay Design |
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Author / Journal |
Abstract |
| Mammalian RNAi: a practical guide. |
Sandy P, Ventura A, Jacks T.
Biotechniques. 2005 Aug;39(2):215-24 |
abstract |
| RNAi: the nuts and bolts of the RISC machine. |
Filipowicz W.
Cell. 2005 Jul 15;122(1):17-20 |
abstract |
| The best control for the specificity of RNAi. |
Sarov M, Stewart AF.
Trends Biotechnol. 2005 Sep;23(9):446-8 |
abstract |
| Detection of foreign RNA: implications for RNAi. |
de Veer MJ, Sledz CA, Williams BR.
Immunol Cell Biol. 2005 Jun;83(3):224-8 |
abstract |
| Defining and assaying RNAi in mammalian cells. |
Huppi K, Martin SE, Caplen NJ.
Mol. Cell. 2005 Jan 7;17(1):1-10 |
abstract |
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| Reviews |
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Author / Journal |
Abstract |
| Strategies for silencing human disease using RNA interference. |
Kim DH, et al.
Curr Opin Oncol. 2007. Jan; 19(1): 50-4. Review.
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abstract |
| RNA interference technologies and their use in Cancer Res.earch. |
Gaither A, Iourgenko V.
Curr Opin Oncol. 2007. Jan; 19(1): 50-4. Review.
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abstract |
| Toxicity in mice expressing short hairpin RNAs gives new insight into RNAi. |
Snove O Jr, Rossi JJ.
Genome Biol. 2006; 7(8): 231. Review.
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abstract |
| RNA interference in mice. |
Kuhn R, Streif S, Wurst W.
Handb Exp Pharmacol. 2007; 178: 149-76. Review.
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abstract |
| RNA interference: natural, experimental, and clinical roles in cancer biology. |
Mroz EA, Rocco JW.
Head Neck. 2006; Dec; 28(12): 1132-41. Review.
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abstract |
| Gene Silencing by Small Regulatory RNAs in Mammalian Cells. |
Scherr M, Eder M.
Cell Cycle. 2007; Feb 5; 6(4). |
abstract |
| RNA Interference: A New Approach to In Vivo Study of Gene Function. |
Anthony RV, Cantlon JD.
J Anim Sci. 2006. Oct; 13; [Epub ahead of print].
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abstract |
| RNAi therapy for neurodegenerative diseases. |
Boudreau RL, Davidson BL
Curr Top Dev Biol. 2006. 75: 73-92. Review.
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abstract |
| RNA interference: a potential revolution in disease therapy. |
Waseem T.
J Coll Physicians Surg Pak. 2006. Jul; 16(7): 491-2. Review.
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abstract |
| RNA interference and potential applications |
Zhou D, He QS, Wang C, Zhang J, Wong-Staal F.
Curr Top Med Chem. 2006; 6(9): 901-11. Review |
abstract |
| The RNA interference revolution |
Lenz G.
Braz J Med Biol Res. 2005 Dec; 38(12): 1749-57. Epub 2005 Nov 9. Review |
abstract |
| Biology calls the targets: combining RNAi and disease biology. |
van Es HH, Arts GJ.
Drug Discov Today. 2005 Oct 15;10(20):1385-91 |
abstract |
| RNA interference in neuroscience: progress and challenges. |
Miller VM, Paulson HL, Gonzalez-Alegre P.
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