CompoZr Zinc Finger Nuclease Technology
Zinc finger nucleases (ZFNs) are a class of engineered DNA-binding proteins that facilitate targeted editing of the genome by creating double-strand breaks in DNA at user-specified locations.
Double-strand breaks are important for site-specific mutagenesis in that they stimulate the cell’s natural DNA-repair processes, namely homologous recombination and Non-Homologous End Joining (NHEJ).
Using well-established and robust protocols, these cellular processes can be harnessed to generate precisely targeted genomic edits resulting in cell lines, including somatic cell lines, with targeted gene deletions (Knockouts), integrations, or modifications.
Visit www.editforthebetter.com to watch the introductory video and enter
the Edit Your World contest.
Email us at zfn@sial.com with questions or to have a Sigma® representative
contact you about our CompoZr Custom ZFN Service. For information or label licenses,
visit the ZFN Label License page.
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