Magnolol

Magnolol
from plant

Magnolol is a bioactive plant component isolated from the root and stem bark of Magnolia officinalis. Magnolol displays an array of activities including antifungal,¹ antibacterial, and antioxidant effects.² Magnolol has also been shown act as a natural inhibitor to acyl-CoA: cholesterol acyltransferase (ACAT).³

Magnolol has been shown to demonstrate anti-inflammatory activity by interfering with NF-kB signaling. It also appears to have anti-inflammatory properties related to vascular disorders such as atherosclerosis due to its ability to inhibit IL-6-induced STAT3 activation.⁴

Product Number: M3445

Synonym: 5,5′-Diallyl-2,2′-biphenyldiol
Molecular Formula: C₁₈H₁₈O₂
Molecular Weight: 266.33
CAS Number: 528-43-8

Preparation Instructions
Soluble in ethanol at 1 mg/ml. Also soluble methanol at 1.5 mg/ml.

Storage Conditions
Store at 2-8 °C. Under these conditions the product is stable for at least 2 years.

1. Bang, K.H., et al., Antifungal activity of magnolol and honokiol. Arch. Pharm. Res. 23, 46-9, (2000)
   
   
2. Lo, Y.C., et al., Magnolol and honokiol isolated from Magnolia officinalis protect rat heart mitochondria against lipid peroxidation. Biochem. Pharmacol. 47, 549-53, (1994)
   
   
3. Kwon, B.M., et. al., Acyl-CoA: cholesterol acyltransferase inhibitors for Magnolia obovata. Planta Med. 63, 550-551, (1997)
   
   
4. Chen, S.C., et. al., Herbal remedy magnolol suppresses IL-6-induced STAT3 activation and gene expression in endothelial cells. Br. J. Pharmacol. 148, 226-232, (2006)