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Gene regulation, specifically regulation of the leptin receptor and JAK/STAT signal transduction pathway can also influence obesity. Leptin is the product of the obese (ob) gene and is produced predominantly in white adipose tissue. The leptin receptor (Ob-R) isolated by expression cloning, is encoded by the diabetes (db) gene. The arcuate nucleus (ARC) of the hypothalamus serves as the leptin signaling center. Leptin receptor activation stimulates STAT1, STAT3 and STAT5 tyrosine phosphorylation in vitro and STAT3 tyrosine phosphorylation in vivo. The Ob-Rb, long leptin receptor isoform, acts as a potent JAK/STAT signaling activator. Ciliary neurotrophic factor (CNTF) appears to act similar to leptin. CNTF administration has been shown to reduce adiposity much like leptin. Systemic administration of CNTF activates the JAK/STAT pathway in the ARC. Unfortunately, Axokine an analog of CNTF, showed disappointing results in clinical trials for the treatment of obesity. However, there is still promise for gene regulation therapies in the treatment of obesity.
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Control Peptides for Transcription Regulators |
Product # |
Product Name |
Notes |
Add to Cart |
| S4315 |
STAT1α trifluoroacetate salt |
Control peptide for the STAT1α rabbit polyclonal antibody. |
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| S5065 |
[pSer727]-STAT1, mouse trifluoroacetate salt |
Positive control peptide for the [pSer727]-STAT1 rabbit polyclonal antibody. |
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| S5190 |
[Ser727]-STAT1 trifluoroacetate salt |
Negative control peptide for the [pSer727]-STAT1 rabbit polyclonal antibody. |
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| S4065 | [pTyr701]-STAT1 trifluoroacetate salt | Positive control peptide for the [pTyr701]-STAT1 rabbit polyclonal antibody. | |
| S4190 | [Tyr701]-STAT1 trifluoroacetate salt | Negative control peptide for the [pTyr701]-STAT1 rabbit polyclonal antibody. | |
| S4440 | STAT2 (830-849) trifluoroacetate salt | Control peptide for the STAT2 rabbit polyclonal antibody. | |
| S4565 | STAT3 (733-748) trifluoroacetate salt | Control peptide for the STAT3 rabbit polyclonal antibody. | |
| S4815 |
[pTyr705]-STAT3, mouse trifluoroacetate salt |
Positive control peptide for the [pTyr705]-STAT3 (mouse) rabbit polyclonal antibody. |
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| S4940 |
[Tyr705]-STAT3, mouse trifluoroacetate salt |
Negative control peptide for the [pTyr705]-STAT3 (mouse) rabbit polyclonal antibody. |
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| S5315 |
[pSer727]-STAT3 trifluoroacetate salt |
Positive control peptide for the [pSer727]-STAT3 rabbit polyclonal antibody. |
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| S4690 |
STAT4 trifluoroacetate salt |
Positive control peptide for the STAT4 rabbit polyclonal antibody. |
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Antibodies to Transcription Regulators |
| Product # |
Product Name | Species Reactivity | Immunogen | Application | Add to Cart |
| S2190 |
Anti-STAT1α, Rabbit affinity isolated antibody |
Mouse | Mouse STAT1α |
Immunoblotting | |
| S4558 | Anti-phospho-STAT1 (pSer727), Rabbit IgG fraction of antiserum | Human, mouse, rat | Synthetic phosphopeptide corresponding to amino acids 718-730 of human STAT1 that contains serine 727 | Indirect Immunoblotting | |
| S2315 | Anti-phospho-STAT1 (pTyr701), Rabbit affinity isolated antibody | Human, mouse | Synthetic phosphopeptide derived from the region of human STAT1 that contains tyrosine 701 | Immunoblotting | |
| S2565 | Anti-phospho-STAT1 (pTyr701), mouse, (Anti-mSTAT 1 (pT701), Rabbit affinity isolated antibody | Mouse, human (weaker), rat | ISynthetic phosphopeptide derived from the region of murine STAT1 that contains tyrosine 701 | Immunoblotting | |
| S4183 | Monoclonal Anti-phospho-STAT3 (pTyr705), Clone 9E12; Mouse purified immunoglobulin | Human, mouse | Synthetic phosphopeptide containing the AP[pY]LK motif of human STAT3 | Indirect Immunoblotting, Immunoprecipitation | |
| S2690 | Anti-phospho-STAT3 (pTyr705), Rabbit affinity isolated antibody | Human, mouse, rat | Synthetic phosphopeptide derived from the region of human STAT3 that contains tyrosine 705 | Immunoblotting | |
| S5683 | Anti-STAT1, Rabbit IgG fraction of antiserum | Human, mouse | GST fusion protein containing amino acids 714-750 of the C-terminal region of human STAT1, expressed in E. coli | Indirect Immunoblotting, Immunoprecipitation | |
| S5808 | Anti-STAT2, Rabbit IgG fraction of antiserum | Human, mouse | GST fusion protein containing amino acids 671-806 of the C-terminal region of human STAT2, expressed in E. coli | Indirect Immunoblotting, Immunoprecipitation | |
| S5933 | Anti-STAT3, Rabbit IgG fraction of antiserum | Human, mouse, rat | GST fusion protein corresponding to amino acids 688-722 of human STAT3, expressed in bacteria | Indirect Immunoblotting, Immunoprecipitation | |
| S5558 | Anti-STAT4, Rabbit affinity isolated antibody | Mouse, human, rat | Synthetic peptide corresponding to amino acids 732-749 of mouse STAT4 | Indirect Immunoblotting | |
| S6058 | Anti-STAT5A, Rabbit IgG fraction of antiserum | Human, mouse | Synthetic peptide corresponding to amino acids 778-794 of human STAT5A | Indirect Immunoblotting, Immunoprecipitation | |
| S6183 | Anti-STAT5B, Rabbit IgG fraction of antiserum | Human, mouse | Synthetic peptide corresponding to amino acids 774-787 of human STAT5B | Indirect Immunoblotting, Immunoprecipitation | |
| S4308 | Monoclonal Anti-phospho-STAT5A/B, (pTyr694,699), Clone 8-5-2; Isotype IgG1, Mouse purified immunoglobulin | Human, mouse, rat, bovine, sheep | Synthetic phosphopeptide corresponding to amino acids 689-700 of human STAT5A and amino acids 694-705 of human STAT5B | Indirect immunoblotting | |
| S5058 | Anti-phospho-STAT5A/B (pTyr694,699), Rabbit IgG fraction of antiserum | Human, mouse, rat | Synthetic phosphopeptide, corresponding to amino acids 687-698 of human STAT5 | Immunoblotting | |
| S6308 | Anti-STAT6 (689-711), Rabbit IgG fraction of antiserum | Human | Synthetic peptide corresponding to amino acids 689-711 of human STAT6 | Indirect Immunoblotting, Immunoprecipitation | |
| S6433 | Anti-STAT6 (787-804), Rabbit whole antiserum | Human, mouse (weakly) | Synthetic peptide corresponding to amino acids 787-804 of human STAT6 | Immunoblotting | |
| S5061 | Anti-phospho-STAT6 (pTyr641), Rabbit affinity isolated antibody | Human, mouse | Synthetic phosphopeptide derived from the region of STAT6 that contains tyrosine 641 | Immunoblotting | |
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