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Developed in collaboration with the Protein Quantitation Consortium, Sigma's AQUA Peptides enable accurate, efficient mass spectrometric quantitation of protein biomarkers.
- Focus your analysis on significant protein biomarkers
- Accurately quantitate low abundance proteins
- Eliminate costly, time consuming stable isotope labeling steps
- Measure site-specific phosphorylation states
- Validate gene silencing at the protein level
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View additional information on the Protein AQUA Strategy and Protein AQUA Applications
This method was developed by Dr. Steve Gygi and colleagues at Harvard Medical School [Stemmann O, Zou H, Gerber SA, Gygi SP, Kirschner MW; Dual inhibition of sister chromatid separation at metaphase, Cell 2001, Dec 14, 107: 715-726] and is the subject of both U.S. and PCT Patent Applications. Limited use of this method is permitted under a licensing arrangement with Harvard Medical School.
The AQUA Peptide Partnership Program and Library
Sigma is pleased to announce the launch of its AQUA Peptide Partnership Program and the upcoming debut of the AQUA Peptide Library. With over 400 library peptides in development, the AQUA Peptide Library promises even greater convenience and value for quantitative proteomics research.
We invite you, the proteomics community, to contribute to the AQUA Peptide Library through the AQUA Peptide Partnership Program. When you order custom AQUA Peptides, you will be invited to add your sequences to the library. Contributors will receive partnership pricing on their custom orders. The larger proteomics community will enjoy the benefit of accessing the sequences quickly and conveniently in the following months.
Peptides in the AQUA Peptide Library will be available to purchase in the coming weeks, with new peptides being added rapidly. We look forward to working with you to build the library together!
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Custom AQUA Peptides
To meet the specific demands of AQUA experimentation, Sigma has developed a specialized custom peptide offering. Custom AQUA Peptides are synthesized using fully labeled
98 atom% 13C and 98 atom% 15N enriched amino acids (one labeled amino acid per peptide) and are stringently tested to ensure high purity (HPLC), accurate molecular weight
(ESI-MS), and specific peptide content.
To order Custom AQUA Peptides, call 1-800-325-3010 or visit
sigma.com/aquaorder. |
- >95% pure by HPLC
- quantitated by AAA
- confirmed by ESI-MS
- 5 × 1 nmol packages
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