Panorama Human p53 Protein Function Microarray is the first fully functional protein array that allows parallel analysis of your protein against multiple p53 proteins. The p53 functional array utilizes a proprietary tagging technology that is based on the presence and biotinylation of a BCCP (biotin-carboxy carrier protein) tag. When the fusion protein is correctly folded and thus functional, the expressed BCCP tag becomes biotinylated. The BCCP-biotin complex then securely tethers the spotted protein to the streptavidin coated slide.
The p53 functional protein microarray contains a human wild-type p53 and 49 SNP variants plus experimental controls to ensure the p53 protein has been spotted and is functional. The p53 proteins are printed in duplicate on a 1 x 3 inch glass slide and sequence verified. Unlike other protein microarrays which use a nitrocellulose coated slide, our p53 proteins are spotted on a streptavidin coated slide which significantly reduces background problems commonly associated with nitrocellulose.
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