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ProClin™ Preservative |
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Biocides |
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ProClin Preservative
• Broad-spectrum
antimicrobial activity controls bacteria, yeast, and fungi
• Compatible
with key enzymes
• Do not inhibit antibody binding
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Excellent stability
• Effective at pH 2-12
• Less toxic
than thimerosal
• Easy-to-use liquid formulations
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ProClin preservatives are highly effective biocides for
controlling microorganisms in reagents and products intended for in vitro
diagnostic use. At concentrations as low as 0.02%, these preservatives eradicate
bacteria, fungi, and yeast for extended periods of time. Both preservatives
offer excellent compatibility and stability with most enzyme systems, as
well as low toxicity.
ProClin preservatives are an excellent choice for replacing thimerosal,
sodium azide, and gentamicin preservatives.
Mechanism
of Action
The active components in ProClin preservative are two isothiazolones: 2-methyl-4-isothiazolin-3-one
and 5-chloro-2-methyl-4- isothiazolin-3-one. These active components have
a unique mechanism of action that both inhibits microbe growth and causes
cell death. Within minutes after contacting a microorganism, the active
components penetrate the cell membrane and inhibit specific enzymes in the
cell, inhibiting growth, macromolecule synthesis, respiration, and cause
intracellular energy levels to decline rapidly. With energy production disrupted,
the cell can no longer synthesize chemicals for routine operation or repair.
Ultimately the cell dies. The target enzymes are within the central metabolic
cycle of the cell, the Krebs cycle (pyruvate dehydrogenase, a-ketoglutarate
dehydrogenase, succinate dehydrogenase, NADH dehydrogenase), affording microbes
little chance to develop resistance. |
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| Biocides for Diagnostic Manufacturing |
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| Characteristics |
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Proclin 150 |
Proclin 200 |
ProClin 300 |
ProClin 950 |
| Composition |
| Active Ingredients1 |
1.5% |
1.5% |
3.0% |
9.5%2 |
| Matrix |
water |
water |
propylene glycol |
water |
| Stabilizer |
23–25% Mg salts |
3% Mg salts |
alkyl carboxylate |
none |
| Recommended Level of Use |
| (as supplied,%) |
0.04–0.10 |
0.04–0.10 |
0.02–0.05 |
0.02–0.05 |
| Shelf Life |
3 years |
3 years |
3 years |
24 months |
| Applications |
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| in vitro diagnostic kits and kit components,
calibration solutions, control solutions, organic reagents. |
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1 5-Chloro-2-methyl-4-isothiazolin-3-one and
2-methyl-4-isothiazolin-3-one
2 2-Methyl-4-isothiazolin-3-one only |
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| ProClin Evaluation Kits - The evaluation kits are
designed for investigating, on a small scale, the suitability of ProClin
preservatives in new product development. Each individual kit contains three
different manufactured lots of the ProClin preservatives for testing consistency
of performance from lot to lot. The ProClin Variety Kit includes 5 mL each
of ProClin 150, 200, 300, and 950 preservatives
and is intended to be used as an aide in determining the appropriate ProClin
product for a specific application. Also included is a Certificate of Analysis
for each lot of preservative and an instruction booklet. |
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| ProClin Evaluation Kits |
| Cat. No. |
Description |
Add to order |
| 48121 |
ProClin 150 3 × 5 mL |
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| 49381-U |
ProClin 150 3 × 400 mL |
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| 48911-U |
ProClin 300 3 × 5 mL |
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| 48119-U |
ProClin Variety Kit |
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| ProClin Preservatives |
Restrictions on the Use of Biocides
The sale and use of biocides in the United States are closely regulated
by federal laws.
ProClin preservatives are labeled for use only as preservatives for in vitro
clinical diagnostic reagents. Such in vitro diagnostic reagents are considered
medical devices and are regulated by the US Food and Drug Administration
(US FDA) under the Food, Drug & Cosmetic Act. Any other application
is prohibited.
To help you meet regulatory compliance, a company representative will contact
you prior to shipment of your first trial order. |
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