It is well documented that physicochemical properties can be correlated to many ADME properties, particularly in terms of absorption.
It is therefore essential that as part of any lead-optimisation program, physicochemical properties are optimised in parallel with activity and selectivity measurements to help identify potential drugs.
Pharmorphix has developed a suite of integrated semi-automated physicochemical property assays that address the following areas:
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Ionization state from pKa. |
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Permeability from LogP/LogD in octanol/water. |
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Solubility - themodynamic and kinetic in physiologically relevant media. |
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Stability - chemical and physical |
 Many of these assays can utilise stock solutions in DMSO and sample requirements have been minimised by use of miniaturised assay conditions and sensitive detection methods such as UV Diode Array.
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