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Biocides & Preservatives |
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For an enviromentally friendly diagnostics manufacturing processes |
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| ProClin preservatives are an excellent choice for replacing thimerosal, sodium azide and gentamicin preservatives. In addition they are highly effective, broad-spectrum biocides for controlling microorganisms in reagents and products intended for in vitro diagnostics use. At concentrations as low as 0.02%, these preservatives eradicate bacteria, fungi and yeast for extended periods of time. |
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Compatibility with key enzymes and assay indicators |
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Will not inhibit antibody binding |
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Easy-to-use water-soluble liquid, effective at very low concentrations (6-20ppm) |
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Excellent stability over a wide pH range (2 to 8.5) |
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Level of active ingredients assayable by HPLC (Inquire for a HPLC standard) |
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At recommended usage levels, ProClin presents no health hazards, toxological problems or disposal issues |
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The active components of ProClin are two isothiazolones, 2-methyl-4-isothiazolin-3-one and 5-chloro-2-methyl-4-isothiazolin-3-one.
Within minutes of contacting a microorganism, the active components penetrate the cell wall and inhibit specific enzymes (at the points noted in red in the Krebs Cycle).
Growth, macromolecule synthesis and respiration are inhibited, ultimately leading to cell death. |
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ProClin Evaluation Kits are available for determining the suitability of ProClin products in new product development. Each evaluation kit contains three different manufactured lots of ProClin for testing performance consistency from lot to lot.
To determine the appropriate ProClin product for a specific application, ProClin variety kits are also available. Each kit contains 5 ml of Proclin 150, 200, 300 and 950. |
| ProClin Evaluation Kits |
| 48121-U |
ProClin 150 – 3 x 5ml (3 lot numbers) |
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49381-U |
ProClin 150 – 3 x 400ml (3 lot numbers) |
| 48911-U |
ProClin 300 – 3 x 5ml (3 lot numbers) |
| 48119-U |
ProClin Variety Kit – 5ml each of ProClin 150, 200, 300 & 950 as an aid to select the appropriate ProClin product for a specific application |
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| Active (A.I.) |
CMIT/MIT |
CMIT/MIT |
CMIT/MIT |
MIT |
| % total A.I. |
1.5 |
1.5 |
3 |
9.5 |
| Salt Stabilizers |
23 – 25% Mg salts |
3% Mg salts |
Alkyl Carboxylate |
none |
| Matrix |
Water |
Water |
Propylene glycol |
Water |
| Working pH Range |
2.5 – 8.5 |
2.5 – 8.5 |
2.5 – 8.5 |
2 – 12 |
| Typical Dosage Levels |
0.05 – 0.10% |
0.05 – 0.10% |
0.02 – 0.07% |
0.05 – 0.10% |
| Shelf Life |
3 years |
3 years |
3 years |
24 months |
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