SAFC Supply Solutions - Proligo® Reagents - Standard RNA Phosphoramidites

Standard RNA Phosphoramidite
	Proligo® Reagents

Product Breadth of Proligo Reagents

Phosphoramidites :
	Pharmadite®
	DNA Phosphoramidites
	RNA Phosphoramidites
	2'O-Methyl RNA Phosphoramidites
Fast Deprotection Chemistries :
	DNA
	RNA

Modifications :
	Fluorescein Phosphoramidite
	Biotin Phosphoramidite
	Phosphate-ON Phosphoramidite
	Non Standard Nucleosides
Linkers :
	Amino Linkers
	ssH Linker

Product Breadth of Proligo Reagents

RNA plays a pivotal role in biological systems due to its numerous function in the transfer and processing of genetic information. The unique properties of RNA have stimulated the development of a variety of applications in diagnostics and therapeutics, as well as in basic molecular biology research where RNA can be used as:
	Catalytic agents (ribozymes)
	Affinity ligands (aptamers)
	Agents to induce gene silencing (RNA interference)
Today, RNA interference (RNAi) has become a popular tool for the sequence-specific inhibition of gene expression and can be used in target validation and other drug development techniques. The most convenient method to provide sequence specific RNA oligonucleotides is chemical synthesis on a solid support with RNA phosphoramidites and RNA CPG, analogous to DNA synthesis.

Key features of Standard RNA Amidites

	Industry standard 2'-TBDMS protective group
	Lot-to-lot consistent purity and performance
	Compatible with deprotection methods based on methylamine or AMA
	Standard RNA Amidites provide excellent coupling results when used together with ETT or BTT as activator; best results are obtained with Activator 42™¹
	Capping with standard acetic anhydride capping reagent rather than with Fast Deprotection Cap A
	Manufactured under a certified ISO 9001 quality system



	Download Literature:
	•	Product Flyer Standard RNA Phosphoramidites (67k pdf)
	•	RNA Phosphoramidites
	View Structure:
	•	rA(bz) Amidite
	•	rC(ac) Amidite
	•	rG(ib) Amidite
	•	rU Amidite

RNA Phosphoramidites
Compatible with Expedite™ and Polygen® Instruments
Product No.	Description	Unit
A212081-01	DMT-2′-O-TBDMS-rA(tac) amidite	1 x 0.5g
C212081-01	DMT-2′-O-TBDMS-rC(tac) amidite	1 x 0.5g
G212081-01	DMT-2′-O-TBDMS-rG(tac) amidite	1 x 0.5g
U211081-01	DMT-2′-O-TBDMS-rU amidite	1 x 0.5g
Compatible with ABI™ Instruments
Product No.	Description	Unit
A212031-01	DMT-2′-O-TBDMS-rA(tac) amidite	1 x 0.5g
A212061-01	DMT-2′-O-TBDMS-rA(tac) amidite	1 g
C212031-01	DMT-2′-O-TBDMS-rC(tac) amidite	1 x 0.5g
C212061-01	DMT-2′-O-TBDMS-rC(tac) amidite	1 g
G212031-01	DMT-2′-O-TBDMS-rG(tac) amidite	1 x 0.5g
G212061-01	DMT-2′-O-TBDMS-rG(tac) amidite	1 g
U211031-01	DMT-2′-O-TBDMS-rU amidite	1 x 0.5g
U211061-01	DMT-2′-O-TBDMS-rU amidite	1 g
Compatible with MerMade™ Instruments
Product No.	Description	Unit
A212028-06	DMT-2′-O-TBDMS-rA(tac) amidite
C212028-06	DMT-2′-O-TBDMS-rC(tac) amidite
G212028-06	DMT-2′-O-TBDMS-rG(tac) amidite
U211028-06	DMT-2′-O-TBDMS-rU amidite
Bulk Quantities
Product No.	Description	Unit
A212010-01	DMT-2′-O-TBDMS-rA(tac) amidite
C212010-01	DMT-2′-O-TBDMS-rC(tac) amidite
G212010-01	DMT-2′-O-TBDMS-rG(tac) amidite
U211010-01	DMT-2′-O-TBDMS-rU amidite
Custom products	Bulk packaging up to multiple kg per container and customized packaging with alternative quantities of amidites are available

¹Activator 42 = 5-(3,5-Bis(trifluoromethyl)phenyl)-1H-tetrazole, a very powerful activator for RNA- and DNA phosphoramidites, commercially available through SAFC Proligo Reagents. To order or speak with a Customer Service Representative, contact your local SAFC office.
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