High Resolution Mass Spectrometry (HRMS)

Separation and identification of individual congeners requires specialized instrumentation, such as a high resolution GC column coupled to a high resolution mass spectrometer. Analyte types include the congeners of dioxins, furans, polychlorinated biphenyls (PCBs), and polybrominated diphenyl ethers (PBDEs). These methods may require a screening procedure using low resolution instrumentation prior to an isotope dilution mass spectrometry analysis performed on high resolution instrumentation. Prior to analysis, samples first undergo an extraction process which partitions analytes into an organic solvent compatible with the instrumentation. Example US EPA methods include 1613, 1614, 1668, 8280, 8290, DLM02.2, and TO-9.