ToyoScreen® Process Development Columns

In manufacturing, chromatography unit operations are some of the most critical in the purification of a new recombinant theraputic protein. In many cases two to four chromatographic steps are needed to achieve the desired purity level for the target molecule.
The first part of the development process is the laboratory scale screening and selection of a resin. Due to the diversity in available ligand chemistries and base matrices offered by different vendors (e.g., agarose, methacrylate, styrene/divinylbenzene, etc.) it is prudent at this stage to screen as many resins as possible. A thorough evaluation is a necessity as each target molecule has very different physical and chromatographic properties. Very often a resin that worked in the past for a similar molecule will not work as effectively for the new target molecule.
Historically, resin screening was accomplished by manually packing various bulk resins into small columns requiring a significant investment in time and cost. To improve the efficiency of resin screening experiments, pre-packed ToyoScreen columns containing the most popular Toyopearl resins provide a low cost and convenient alternative for the evaluation of Toyopearl ligand chemistries.

Features & Benefits
  • Pre-packed columns: Easy to set up and screen an entire resin series for a specific chromatographic mode
  • 1mL and 5mL columns: For sample limited applications with up to milligram purifications
  • Cartridge design: Provides low cost, efficient alternative to self packing with bulk resin
  • Easy connections with ÄKTA®, FPLC and HPLC systems: Seamless integration with any platform
  • Offered in mixed or single chemistry in 6-packs: For cost savings in screening or process optimization experiments

Toyoscreen® Accessories

Product #

Description

Add to Cart

842196 Adapter, M6 to 10-32, PEEK PEEK, pkg of 1 ea
842197 Adapter, 1/4-28 to 10-32, PEEK PEEK, pkg of 1 ea
842195 Column Coupler thread 10-32, pkg of 1 ea, stainless steel tubing (0.03" ID)
842194 ToyoScreen® Holder with Fittings polycarbonate housing, polypropylene cap, PEEK adapter, pkg of 1 kit
821400 TSKgel® Hardware and Accessories polycarbonate housing, polypropylene cap, pkg of 1 ea

ToyoScreen® Affinity Process Development Columns

Product #

Description

Phase

Particle Size

Pkg Qty

Add to Cart

823431 ToyoScreen® AF-rProtein A HC-650F Process Development Column rProtein A phase
45 μm
pkg of 1 × 5 mL
823430 ToyoScreen® AF-rProtein A HC-650F Process Development Column rProtein A phase
45 μm
pkg of 5 × 1 mL
823432 ToyoScreen® AF-rProtein A HC-650F Process Development Column rProtein A phase
45 μm
pkg of 5 × 5 mL

ToyoScreen® Anion Exchange Process Development Columns

Product #

Description

Phase

Particle Size

Pkg Qty

Add to Cart

821360 ToyoScreen® DEAE-650M Process Development Column DEAE (diethylaminoethyl) phase
65 μm
pkg of 6 × 1 mL
821361 ToyoScreen® DEAE-650M Process Development Column DEAE (diethylaminoethyl) phase
65 μm
pkg of 6 × 5 mL
822872 ToyoScreen® GigaCap DEAE-650M Process Development Column DEAE (diethylaminoethyl) phase
75 μm
pkg of 6 × 1 mL
822873 ToyoScreen® GigaCap DEAE-650M Process Development Column DEAE (diethylaminoethyl) phase
75 μm
pkg of 6 × 5 mL
821859 ToyoScreen® GigaCap Q-650M Process Development Column ammonium ion, quaternary phase
75 μm
pkg of 6 × 1 mL
821860 ToyoScreen® GigaCap Q-650M Process Development Column ammonium ion, quaternary phase
75 μm
pkg of 6 × 5 mL
821392 ToyoScreen® IEC Anion Mix Pack Process Development Column mixed phase
  pkg of 1 × 1 mL 5 grades
821393 ToyoScreen® IEC Anion Mix Pack Process Development Column mixed phase
  pkg of 1 × 5 mL 5 grades
821396 ToyoScreen® IEC Mix Pack Process Development Column mixed phase
  pkg of 1 × 1 mL 6 grades
821397 ToyoScreen® IEC Mix Pack Process Development Column mixed phase
  pkg of 1 × 5 mL 6 grades
821992 ToyoScreen® Q-600C AR Process Development Column ammonium ion, quaternary phase
100 μm
pkg of 6 × 1 mL
821993 ToyoScreen® Q-600C AR Process Development Column ammonium ion, quaternary phase
100 μm
pkg of 6 × 5 mL
821364 ToyoScreen® QAE-550C Process Development Column ammonium ion, quaternary phase
100 μm
pkg of 6 × 1 mL
821365 ToyoScreen® QAE-550C Process Development Column ammonium ion, quaternary phase
100 μm
pkg of 6 × 5 mL
821362 ToyoScreen® SuperQ-650M Process Development Column ammonium ion, quaternary phase
65 μm
pkg of 6 × 1 mL
821363 ToyoScreen® SuperQ-650M Process Development Column ammonium ion, quaternary phase
65 μm
pkg of 6 × 5 mL

ToyoScreen® Cation Exchange Process Development Columns

Product #

Description

Phase

Particle Size

Pkg Qty

Add to Cart

821366 ToyoScreen® CM-650M Process Development Column carboxymethyl phase
65 μm
pkg of 6 × 1 mL
821367 ToyoScreen® CM-650M Process Development Column carboxymethyl phase
65 μm
pkg of 6 × 5 mL
821951 ToyoScreen® GigaCap CM-650M Process Development Column carboxymethyl phase
75 μm
pkg of 6 × 1 mL
821952 ToyoScreen® GigaCap CM-650M Process Development Column carboxymethyl phase
75 μm
pkg of 6 × 5 mL
821868 ToyoScreen® GigaCap S-650M Process Development Column sulphonyl phase
75 μm
pkg of 6 × 1 mL
821869 ToyoScreen® GigaCap S-650M Process Development Column sulphonyl phase
75 μm
pkg of 6 × 5 mL
821394 ToyoScreen® IEC Cation Mix Pack Process Development Column mixed phase
  pkg of 1 × 1 mL (5 grades)
821395 ToyoScreen® IEC Cation Mix Pack Process Development Column mixed phase
  pkg of 1 × 5 mL 5 grades
821396 ToyoScreen® IEC Mix Pack Process Development Column mixed phase
  pkg of 1 × 1 mL 6 grades
821397 ToyoScreen® IEC Mix Pack Process Development Column mixed phase
  pkg of 1 × 5 mL 6 grades
821870 ToyoScreen® MegaCap II SP-550EC Process Development Column sulfonic acid phase
200 μm
pkg of 6 × 1 mL
821871 ToyoScreen® MegaCap II SP-550EC Process Development Column sulfonic acid phase
200 μm
pkg of 6 × 5 mL
821370 ToyoScreen® SP-550C Process Development Column sulfonic acid phase
100 μm
pkg of 6 × 1 mL
821371 ToyoScreen® SP-550C Process Development Column sulfonic acid phase
100 μm
pkg of 6 × 5 mL
821368 ToyoScreen® SP-650M Process Development Column sulfonic acid phase
65 μm
pkg of 6 × 1 mL
821369 ToyoScreen® SP-650M Process Development Column sulfonic acid phase
65 μm
pkg of 6 × 5 mL

ToyoScreen® Hydrophobic Interaction Process Development Columns

Product #

Description

Phase

Particle Size

Pkg Qty

Add to Cart

821494 ToyoScreen® Butyl-600M Product Development Column C4 (butyl) phase
65 μm
pkg of 6 × 1 mL
821495 ToyoScreen® Butyl-600M Product Development Column C4 (butyl) phase
65 μm
pkg of 6 × 5 mL
821376 ToyoScreen® Butyl-650M Process Development Column C4 (butyl) phase
65 μm
pkg of 6 × 1 mL
821377 ToyoScreen® Butyl-650M Process Development Column C4 (butyl) phase
65 μm
pkg of 6 × 5 mL
821372 ToyoScreen® Ether-650M Process Development Column ether phase
65 μm
pkg of 6 × 1 mL
821373 ToyoScreen® Ether-650M Process Development Column ether phase
65 μm
pkg of 6 × 5 mL
821398 ToyoScreen® HIC Mix Pack Process Development Column mixed phase
  pkg of 1 × 1 mL
821399 ToyoScreen® HIC Mix Pack Process Development Column mixed phase
  pkg of 1 × 5 mL (6 grades)
821378 ToyoScreen® Hexyl-650C Process Development Column C6 (hexyl) phase
100 μm
pkg of 6 × 1 mL
821379 ToyoScreen® Hexyl-650C Process Development Column C6 (hexyl) phase
100 μm
pkg of 6 × 5 mL
821380 ToyoScreen® PPG-600M Process Development Column polypropylene glycol phase
65 μm
pkg of 6 × 1 mL
821381 ToyoScreen® PPG-600M Process Development Column polypropylene glycol phase
65 μm
pkg of 6 × 5 mL
821892 ToyoScreen® Phenyl-600M Process Development Column phenyl phase
65 μm
pkg of 6 × 1 mL
821893 ToyoScreen® Phenyl-600M Process Development Column phenyl phase
65 μm
pkg of 6 × 5 mL
821374 ToyoScreen® Phenyl-650M Process Development Column phenyl phase
65 μm
pkg of 6 × 1 mL
821375 ToyoScreen® Phenyl-650M Process Development Column phenyl phase
65 μm
pkg of 6 × 5 mL
821382 ToyoScreen® SuperButyl-550C Process Development Column C4 (butyl) phase
100 μm
pkg of 6 × 1 mL
821383 ToyoScreen® SuperButyl-550C Process Development Column C4 (butyl) phase
100 μm
pkg of 6 × 5 mL

ToyoScreen® Mixed Mode Process Development Columns

Product #

Description

Phase

Particle Size

Pkg Qty

Add to Cart

822824 ToyoScreen® MX-Trp-650M Process Development Column tryptophan phase
75 μm
pkg of 6 × 1 mL
822825 ToyoScreen® MX-Trp-650M Process Development Column tryptophan phase
75 μm
pkg of 6 × 5 mL