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β-cyclodextrin, S-hydroxypropyl ether

The hydroxyl groups on the surface of the beta-cyclodextrin are reacted with either "S" or "R,S" propylene oxide. This has the effect of extending hydrogen-bonding capabilities to accommodate greater distances of the chiral center from an aromatic ring structure. The "S" version (Astec® CYCLOBOND I 2000 SP) sometimes shows enhanced selectivity and efficiency for some separations, e.g., methadone.

Bonded phase: (S)-Hydroxypropyl modified beta-cyclodextrin
Operating pH range: 3 - 7
Particle diameter: 5 or 10 μm
Pore size: 100 Å

Product #


Particle Size

Length × I.D.

Add to Cart

21102AST Astec® CYCLOBOND® I 2000 SP Chiral HPLC Guard 5 μm
2 cm × 4 mm
20224AST Astec® CYCLOBOND® I 2000 SP Chiral HPLC Column 5 μm
25 cm × 4.6 mm
21150AST Supelguard Guard Cartridge Holder