Silica TLC Adsorbents

By far the most common TLC sorbent, silica gel separates compounds via an adsorption process (normal phase solid-liquid chromatography). It forms hydrogen bonds with polar analytes and can distinguish between positional isomers. Silica gel is relatively inert; it does not have the catalytic properties of alumina. Eluants for silica TLC are similar to those for normal phase HPLC.