Solvent Additives

Sigma-Aldrich offers a large selection of high purity acids, bases and salts to control analyte ionization and improve LC-MS signal.

It is common practice in LC-MS to add certain chemicals to the mobile phase or introcuce them post-column prior to the interface to influence analyte ionization. Most often, an improvement in the analyte signal is the goal. However, some additives may be used to suppress unwanted signals or selectively enhance the signal of particular compounds in a mixture, for example glycosidic species in a mixture of peptides.

Sigma-Aldrich, a leading supplier of chemicals for analytical applications, offers a wide range of high purity additives for LC-MS applications in addition to our pure CHROMASOLV^® solvents and ready-to-use blends. Our offering includes the most commonly used acids, bases, volatile salts and a sodium source (see Table). All are of high purity, usually puriss p.a., and are tested for LC-MS application.

Product List...... LC-MS CHROMASOLV^® Mobile Phase Additives

Catalog No.	Description	Package Size	Add to Cart
40967	Trifluoroacetic acid, puriss p.a., eluent additive for LC-MS	HDPE bottle
56302	Formic acid, puriss p.a., eluent additive for LC-MS	HDPE bottle
49199	Acetic acid, puriss p.a., eluent additive for LC-MS	HDPE bottle
49916	Propionic acid, puriss p.a., eluent additive for LC-MS	HDPE bottle
55674	Ammonium formate, puriss p.a., eluent additive for LC-MS	HDPE bottle
49638	Ammonium acetate, puriss p.a., eluent additive for LC-MS	HDPE bottle
61333	Sodium citrate tribasic dihydrate, puriss p.a., eluent additive for LC-MS	HDPE bottle
40867	Ammonium bicarbonate, puriss p.a., eluent additive for LC-MS	HDPE bottle
44273	Ammonium hydroxide solution 25%, puriss p.a., eluent additive for LC-MS	HDPE bottle
65897	Triethylamine, puriss p.a., eluent additive for LC-MS	HDPE bottle

LC Solvents