Alkylation and Esterfication

Alkylation is the replacement of a active hydrogen in R-COOH, R OH, R-SH, and R-NH2 with an alkyl group or, sometimes aryl group. The gas chromatographic properties of compounds are enhanced because of the decreased polarity of the derivatives as compared with the parent compound. Esterification is the first choice for derivatization of acids. Acids are reactive compounds and are too polar to be separated by gas chromatography well; underivatized acids tend to tail because of the adsorption and non-specific interaction with the column.

Esterification is used to derivatize carboxylic acids and other acidic functional groups. In a typical reaction esterification involves the condensation of the carboxyl group of an acid and the hydroxyl group of an alcohol, with the elimination of water. 

View Alkylation & Esterification Products in the Online Catalog

Applications for Alkylation:

BCl₃-2-Chloroethanol, 10% w/w (PDF 52 KB)
BCl₃-Methanol, 12% w/w (PDF 98 KB)
BF3-Butanol, 10% w/w (PDF 100 KB)
BF3-Methanol, 10% w/w (PDF 98 KB)
Methanolic H₂SO₄ (10% v/v) (PDF 110 KB)
Methanolic Base, 0.5N (PDF 88 KB)
Methanolic HCl, 0.5N and 3N (PDF 52 KB)
Pentafluorobenzyl Bromide, Hexaoxacyclooctadecane (PDF 109 KB)
TMAH (PDF 98 KB)