Trace Analysis

Ion Chromatography

Certified Standard Solutions (TraceCERT®)

Certified Eluent Concentrates

Salts and Additives

Water

Qualification Kit


Ion Chromatography Brochure
Ion Chromatography Brochure
(PDF 0.8 MB)


Certified Reference Materials for Demanding Ion Chromatography Applications

Today, ion chromatography (IC) is an important technique within the analytical laboratory. It is used for the aqueous determination of ions down to the ppt range, being one of the best methods that can provide quantitative analysis of ions at this level. Moreover, the development of modern IC apparatus and columns makes this technique a fast, uncomplicated and reliable tool.

The quality of IC standards had to be improved to keep up with the advances in the available hardware. The selection of appropriate standards for the calibration and quality control of an IC system is important. Sigma-Aldrich offers a wide range of certified reference materials for IC, starting from single-ion standards to multi-ion standards. These standards are frequently used by the Environmental, Food and Beverage industries. However, other industries like Pharmaceutical or Semiconductor, may need to work with even higher qualifications and certified standards to comply with GMP.

This trend is furthermore reinforced by official regulations of the European Community within the guideline 96/23/EG on the use of certified reference materials (CRM): … In paragraph 3.1.1.2., the determination of trueness (one component of accuracy) is described: trueness can only be established by means of CRM's. A CRM should be used whenever available… . The American FDA (Food and Drug Administration) demands in their Inspection Guide for analytic methods the usage of reference standards. ISO (International Organization for Standardization) has published more than 6 papers about certified reference materials.

Certified Standard Solutions (TraceCERT®)
TraceCERT® certified reference materials are produced under double-accreditation, fulfilling both ISO/IEC 17025 (General Requirements for the Competence of Testing and Calibration Laboratories) and ISO Guide 34 (General Requirements for the Competence of Reference Material Producers). Information about certified content including measurement uncertainty, traceability and expiry date are stated in the certificate. In most cases relevant impurities are stated for the inorganic single-ion standards.

PRIMUS – Primary Multi-ion Standards
The number of multi-ion CRM available was still small when Sigma-Aldrich launched the PRIMUS standards in 2003. The development was carried out in collaboration with EMPA (former national metrological institute in chemical metrology), located in St. Gallen, Switzerland.
EMPA determined the exact content of the starting materials based on high-purity salts. The contents of these primary materials were determined by two independent methods for each salt. The analyses were done in collaboration with the German metrological institute BAM.
The primary starting materials are diluted with high-purity water using high precision weighing and adequate cleanroom environment to multi-ion standards with concentrations of 10 mg/kg each. Only when sophisticated production procedures are applied it is possible to get expanded uncertainties of 0.2% relative.

To ensure the quality of the PRIMUS standards, each bottle is sealed in an aluminum bag to minimize the loss of solvent and to keep the concentration stable over years. A printed certificate is provided with each product including a detailed certification report regarding the characterization of the starting materials by EMPA and BAM, traceability of certified contents, evaluation of the measurement uncertainties and expiry date.

Did you know that ...
... each new Metrohm IC apparatus contains a pack of our PRIMUS multi-cation or multi-anion standards?
... Metrohm highly recommends the use of PRIMUS standards for the calibration and validation of their instruments?

50 mL HDPE bottle

Cat. No. Product Name Ions Produced from Example
Certificate
89316 Multielement Ion Chromatography Cation Standard Solution, certified 10 mg/kg each:
Li, Na, K, Mg, Ca
Li2CO3, NaCl, KCl, MgO, CaCO3 in diluted HCl
PDF
89886 Multielement Ion Chromatography Anion Standard Solution, certified 10 mg/kg each:
F-, Cl-, Br-, NO3-, PO43-, SO42-
NaF, NaCl, NaBr, NaNO3, Na2SO4, Na2HPO4 in water
PDF
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Multi-ion Standards
100 mL HDPE bottle

Cat. No. Product Name Ions Composition Example
Certificate
69734 Multi Anion Standard 1 for IC 3 mg/L: F-
10 mg/L: Cl- 
20 mg/L: Br-, NO3-, SO42-
30 mg/L: PO43-
NaBr, NaCl, NaF, NaNO3, Na2HPO3, Na2SO4 in water
PDF
53798 Multi Anion Standard 2 for IC 1000 mg/L each: F-, Cl-, Br- NaF, NaCl, NaBr in water
PDF
55698 Multi Anion Standard 3 for IC 1000 mg/L each: NO3-, PO43-, SO42- NaNO3, Na2HPO3, Na2SO4 in water
PDF
80124 Anion Calibration Standard for MARGA (Metrohm Air Monitoring Instrument) 0.25 mg/L each: Br-, Cl-, NO3-, NO2-, SO42- NaBr, NaCl, NaF, NaNO3, NaNO2, Na2SO4 in water
PDF
91286 Multi Cation Standard 1 for IC 50 mg/L: Li
200 mg/L: Na, K, Mg
400 mg/L: NH4+
1000 mg/L: Ca
Li2CO3, NaNO3, KNO3, Mg metal, CaCO3, NH4Cl in ≤0.1% HNO3
PDF
93159 Multi Cation Standard 2 for IC 100 mg/L each: Ba, Ca, K, Li, Mg, Mn, Na, NH4+, Sr NH4Cl, BaCO3, CaCO3, Li2CO3, Mg metal, Mn metal, KNO3, NaNO3, Sr(NO3)2 in ≤0.1% HNO3
PDF
73638 Cation Calibration Standard for MARGA (Metrohm Air Monitoring Instrument) 0.25 mg/L each: NH4+, Ca, Li, Mg, K, Na NH4Cl, CaCO3, Li2CO3, Mg metal, KNO3, NaNO3 in ≤0.1% HNO3
PDF
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Inorganic Anion Standards
1000 mg/L if not otherwise stated, 100 mL HDPE bottle

Cat. No. Product Name Composition Example
Certificate
78476 Bromate Standard for IC KBrO3 in water
PDF
43147 Bromide Standard for IC NaBr in water
PDF
39883 Chloride Standard for IC NaCl in water
PDF
06740 Chloride Standard for IC (10’000 mg/L) NaCl in water
PDF
40121 Chromate Standard for IC KCrO4 in water
PDF
90157 Cyanide Standard for IC K2Zn(CN)4 in water/KOH
PDF
77365 Fluoride Standard for IC NaF in water
PDF
41271 Iodide Standard for IC KI in water
PDF
53638 Nitrate Nitrogen Standard for IC NaNO3 in water
PDF
74246 Nitrate Standard for IC NaNO3 in water
PDF
36427 Nitrite Nitrogen Standard for IC NaNO2 in water/NaOH (pH ~11)
PDF
67276 Nitrite Standard for IC NaNO2 in water/NaOH (pH ~11)
PDF
76462 Perchlorate Standard for IC HClO4 in water
PDF
95924 Phosphate Phosphorous Standard for IC Na2HPO4 in water
PDF
38364 Phosphate Standard for IC Na2HPO4 in water
PDF
75306 Sulfate Sulfur Standard for IC Na2SO4 in water
PDF
90071 Sulfate Standard for IC Na2SO4 in water
PDF
79735 Sulfate Standard for IC (10’000 mg/L) Na2SO4 in water
PDF
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Inorganic Cation Standards
1000 mg/L, 100 mL HDPE bottles

Cat. No. Product Name Composition Example
Certificate
89503 Ammonium Nitrogen Standard for IC NH4Cl in water
PDF
59755 Ammonium Standard for IC NH4Cl in water
PDF
87142 Barium Standard for IC BaCO3 in ≤0.1% HNO3
PDF
69679 Cadmium Standard for IC Cd metal in ≤0.1% HNO3
PDF
39865 Calcium Standard for IC CaCO3 in ≤0.1% HNO3
PDF
49594 Cobalt Standard for IC Co metal in ≤0.1% HNO3
PDF
40786 Copper Standard for IC Cu metal in ≤0.1% HNO3
PDF
51777 Lead Standard for IC Pb(NO3)2 in ≤0.1% HNO3
PDF
59878 Lithium Standard for IC Li2CO3 in ≤0.1% HNO3
PDF
89441 Magnesium Standard for IC Mg metal in ≤0.1% HNO3
PDF
51439 Manganese Standard for IC Mn metal in ≤0.1% HNO3
PDF
42637 Nickel Standard for IC Ni metal in ≤0.1% HNO3
PDF
53337 Potassium Standard for IC KNO3 in water
PDF
43492 Sodium Standard for IC NaNO3 in water
PDF
42151 Strontium Standard for IC Sr(NO3)2 in ≤0.1% HNO3
PDF
67902 Zinc Standard for IC Zn metal in ≤0.1% HNO3
PDF
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Organic Anion Standards
1000 mg/L, 100 mL HDPE bottle

Cat. No. Product Name Composition Example
Certificate
51791 Acetate Standard for IC CH3CO2H and NaOH in water
PDF
40968 Adipate Standard for IC HOOC(CH2)4COOH  in water
PDF
40497 Benzoate Standard for IC C7H6O2 in water
PDF
08089 Butyrate Standard for IC CH3CH2CH2COONa in water
PDF
96068 Citrate Standard for IC HOC(COOH)(CH2COOH)2 in water
PDF
44293 Formate Standard for IC (HCOO)2Ca in water
PDF
74549 Gluconate Standard for IC C6H11NaO7 in water
PDF
07438 Glutarate Standard for IC HOOC(CH2)3COOH in water
PDF
07391 Glycolate Standard for IC HOCH2COOH in water
PDF
07096 Lactate Standard for IC [CH3CH(OH)COO]2Mg · xH2O in water
PDF
06994 Malate Standard for IC HO2CCH2CH(OH)CO2H in water
PDF
06908 Maleate Standard for IC HO2CCH=CHCO2H in water
PDF
42412 Malonate Standard for IC CH2(COOH)2 in water
PDF
42735 Methansulfonate Standard for IC CH3SO3H in water
PDF
73139 Oxalate Standard for IC NaOOCCOONa in water
PDF
90677 Phthalate Standard for IC HOOCC6H4COOK in water
PDF
51716 Propionate Standard for IC CH3CH2COONa in water
PDF
43057 Succinate Standard for IC HOOCCH2CH2COOH in water
PDF
43484 Tartrate Standard for IC HO2CCH(OH)CH(OH)CO2H in water
PDF
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Certified Eluent Concentrates
The certified eluent concentrates for ion chromatography are traceable by potentiometric titration to NIST Standard Reference Materials and certified in accordance with ISO Guide 31. All details about exact content, uncertainty, traceability and expiry date are described in the certificate.

Single Concentrates

Cat. No. Product Name Concentration,
Pack Size
Composition Example
Certificate
50972 2,6-Pyridinedicarboxylic acid concentrate 20 mM,
1 L
C7H5NO4 in water
PDF
50433 DL-Tartaric acid concentrate 100 mM,
1 L
HOOC(CHOH)2COOH in water
PDF
55517 Methanesulfonic acid concentrate 100 mM,
1 L
CH3SO3H (99%) in water
PDF
16355 Nitric acid concentrate 100 mM,
1 L
HNO3 in water
PDF
68487 Oxalic acid concentrate 100 mM,
1 L
HOOCCOOH  in water
PDF
50439 Perchloric acid concentrate 10 mM,
1 L
HClO4 in water
PDF
61699 Potassium hydroxide concentrate 100 mM,
1 L
KOH in water
PDF
36486 Sodium bicarbonate concentrate 100 mM,
1 L
NaHCO3 in water
PDF
72784 Sodium carbonate concentrate1 72 mM,
1 L, 2.5 L
Na2CO3  in water
PDF
56169 Sodium carbonate concentrate 100 mM,
1 L
Na2CO3  in water
PDF
43617 Sodium hydroxide concentrate 50-52%,
500 mL
NaOH in water
PDF
72064 Sodium hydroxide solution 100 mM,
1 L
NaOH in water
68279 Sulfuric acid concentrate 100 mM,
1 L
H2SO4 in water
PDF
86854 Tetrabutylammonium hydroxide solution ~40%,
100 mL, 500 mL, 2.5 L
(CH3CH2CH2CH2)4N(OH) in water
120-fold concentration for Metrohm’s Metrosep A Supp 7 column
2standard CoA available
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Binary Concentrates
In an effort to expand the selection of well-characterized eluent concentrates, a novel group of binary concentrates (20-fold concentration) was introduced. The key features are

  • Application tested using Metrohm’s Metrosep columns
  • Certificate according to ISO Guide 31
  • High-purity starting materials
  • All details about the exact content, specifications, and expiry date are described in the certificate
  • Packaging: 1 L and 2.5 L HDPE bottles with 45 mm screw thread

Cat. No. Product Name Concentration Application Example
Certificate
61905 Nitric acid/Dipicolinic acid concentrate 14 mM C7H5NO4 and 34 mM HNO3 Metrosep C4
PDF
62414 Sodium bicarbonate/Sodium carbonate concentrate 64 mM Na2CO3 and 20 mM NaHCO3 Metrosep A
Supp 5
PDF
75335 Sodium bicarbonate/Sodium carbonate concentrate 100 mM Na2CO3 and 100 mM NaHCO3 Metrosep A
Supp 10
PDF
38302 Sodium carbonate/Sodium hydroxide concentrate 150 mM Na2CO3 and 15 mM NaOH Metrosep A
Supp 16
PDF
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Salts and Additives

Cat. No. Product Name Pack Size Grade
05878 L-Ascorbic acid 100 g C6H8O6, TraceSELECT®, ≥99.9998% (metals basis)
94068 Citric acid monohydrate 100 g HOC(COOH)(CH2COOH)2 • H2O, TraceSELECT®, ≥99.9998% (metals basis)
07673 18-Crown-6 500 mg, 5 g, 10 g C12H24O6 ≥99.0% (GC)
39692 Ethylenediaminetetraacetic acid 25 g (HO2CCH2)2NCH2CH2N(CH2CO2H)2, TraceSELECT®, ≥99.995%
52411 Heptafluorobutyric acid 5 mL, 25 mL CF3CF2CF2COOH ≥99.5% (GC)
78513 D-Mannitol 50 g C6H14O6, TraceSELECT®, ≥99.9999% (metals basis)
17834 Methanesulfonic acid solution 10 mL, 100 mL, 1 L CH3SO3H ~1 M in water
93722 Oxalic acid dihydrate 100 g HO2CCO2H • 2H2O, TraceSELECT®, ≥99.9999% (metals basis)
02321 2,6-​Pyridinedicarboxylic acid 5 g, 10 g C7H5NO4  ≥99.5% (T)
59929 Sodium acetate 25 g, 100 g CH3COONa, TraceSELECT®, for trace analysis, ≥99.999% (metals basis), anhydrous
71347 Sodium carbonate 25 g, 100 g Na2CO3, TraceSELECT®, for trace analysis, ≥99.9999% (metals basis), anhydrous
03918 DL-Tartaric acid 5 g HOOC(CHOH)2COOH, anhydrous, ≥99.5% (T)
12819 DL-Tartaric acid 25 g HOOC(CHOH)2COOH, TraceSELECT®, ≥99.9995% (metals basis)
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Water
Sigma-Aldrich has developed a water quality especially for the needs of ion chromatography. This water is also suitable for trace analysis of anions, cations and also some organics which are usually analyzed by IC. The product is delivered in HDPE bottles with 45 mm thread.

Specification  
Organic traces ≤ 10 µg/kg each: acetate, formiate, glycolate, oxalate
Cation traces ≤ 5 µg/kg each: Al, Ba, Bi, Cd, Co, Cr, Cu, Fe, Li, Mg, Mn, Mo, Ni, Pb, Sr, Zn
≤ 10µg/kg each: Ca, K, Na, NH4+
Anion traces ≤ 1 µg/kg each: bromide, bromate, chlorate, chloride, chlorite, fluoride, iodide, nitrate, nitrite, phosphate, sulfate
Conductivity ≤ 2 µS/cm



Cat. No. Product Name Pack Size
00612 Water for Ion Chromatography 2.5 L, 5 L
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Qualification Kit
The kit is intended for testing detection linearity, injector precision and injector carry-over. The 50 mg/kg standard is used for repeatability tests (injector precision) and the maximum carry-over during injection is verified with the 1000 mg/kg standard. The standards 5 to 100 mg/kg are used to prove the detector linearity. It is a special advantage that the certified bromide standards (produced in a double accredited laboratory fulfilling ISO/IEC 17025 and ISO Guide 34) can be used for conductivity, UV/Vis and electrochemical detectors.

Cat. No. Product Name Composition Example
Certificate
12674 IQ/OQ/PQ Kit for Ion Chromatography Six bromide standards with nominal concentrations of 5, 10, 20, 50, 100 and 1000 mg/kg, produced from high-purity NaBr and water
PDF
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Custom Standard Solutions
If you cannot find the standard you need in our portfolio, you can request a quotation for customized standard solutions for IC using our online custom standards platform.