Application Area & Technique

Phytopharmaceuticals - Primary Reference Standards

Primary Reference Standards for the Analysis of Herbal Medicinal Products

PhytopharmaceuticalsIn collaboration with HWI ANALYTIK GmbH, a company with almost 20 years of experience in the analysis of pharmaceutical products, Sigma-Aldrich provides a new class of primary reference standards for the use in quality control, in-process control and stability testing of herbal medicinal products.

These standards are produced and qualified by HWI ANALYTIK, and are exclusively distributed by Sigma-Aldrich. The novel certification concept of these reference standards is based on the quantitative NMR technique (qNMR) for content assignment. The application of qNMR, a relative primary method of measurement, is advantageous compared to the usual combination of two chromatographic methods, Karl Fischer titration and residual solvent determination due to higher reliability of the certified content value. The analytical report delivered with these products contains two identity proofs, the content by qNMR and the chromatographic purity.

Comprehensive documentation on further parameters, detailed method descriptions and validation data can be ordered directly from HWI ANALYTIK.


Product No. Description Add to Cart
00130590-100mg trans-Anethol
00720585-10mg Apigenin-7-glucoside
00630590-25mg Bisabolol oxide A, primary reference standard
00500590-10mg Chlorogenic acid, primary reference standard
01260595-25mg Coumarin, primary reference standard
00020590-100mg Eucalyptol (1,8-Cineol)
00380590-100mg (+)-Fenchon
00770590-10mg Ginkgolide A, primary reference standard
02580185-10mg * Ginkgolic acid C15:1, primary reference standard
01390590-10mg Ginkgolic acid C17:1, primary reference standard
00170580-10mg Ginsenoside Rb1, primary reference standard
00370580-10mg Ginsenoside Rg1, primary reference standard
00420580-10mg Harpagoside, primary reference standard
01090595-10mg Hulupinic acid, primary reference standard
00190180-10mg * Hypericin, primary reference standard
00180585-10mg Hyperoside, primary reference standard
00140585-10mg Isoquercitrin, primary reference standard
00580590-100mg (-)-Menthol
00040590-100mg alpha-Pinene
00200595-50mg Quercetin dihydrate, primary reference standard
00740580-10mg Quercitrin, primary reference standard
00390580-10mg Rosmarinic acid, primary reference standard
00300590-50mg Rutin trihydrate, primary reference standard
01870575-10mg Sennoside A, primary reference standard
00530580-10mg Sennoside B, primary reference standard
02000585-10mg Silybin, primary reference standard
00670590-100mg Thymol
02010595-10mg Valerenic acid, primary reference standard
00820580-10mg Verbascoside
00660585-10mg Vitexin-2"-O-rhamnoside, primary reference standard
01130595-10mg Xanthohumol, primary reference standard
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* for Ginkgolic acid C15:1 and Hypericin, the content determination by qNMR was not applicable due to overlapping signals. For these two products, the content has been assigned by the usual mode combining two chromatographic methods, water content by Karl Fischer and determination of residual solvents and of inorganic compounds.

A comprehensive list of analytical standards and reference materials for the analysis of herbal medicinal products can be found here.
You can browse our products alphabetically, by substance class or by plant genus.


Additional Literature:

Analytix 01/2010 (PDF, 134 KB)
Product Leaflet quantitative NMR (PDF, 85 KB)