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HPLC
Zr CarbonC18 | ||
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| Discovery Zr-CarbonC18 HPLC columns | ||||||||||||||||||||||||
| Discovery Zr-CarbonC18 consists of spherical, porous carbon-clad zirconia particles covalently modified with octadecyl (C18) groups. It is intended for the reversed-phase separation of acidic and neutral compounds. It complements the selectivity offering of the other zirconia-, silica-, and polymer-based Discovery phases, and allows the use of the full range of mobile phase pH from pH 1 to 14. | ||||||||||||||||||||||||
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| Unique retention and selectivity for method development at pH and temperature extremes | ||||||||||||||||||||||||
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| RAPID LOW pH AND HIGH TEMPERATURE SEPARATIONS | ||||||||||||||||||||||||
| Discovery Zr-CarbonC18 has the partitioning mechanism of C18, but because it is bonded to a highly inert, carbonaceous support, it is immune to pH and temperature extremes. The examples of the acidic non-steroidal anti-inflammatory compounds and in the figures below run at pH 1.75 and 80°C on Discovery Zr-CarbonC18 demonstrates the extreme applicability of this phase. | ||||||||||||||||||||||||
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| RAPID HIGH pH AND HIGH TEMPERATURE SEPARATIONS | ||||||||||||||||||||||||
| Increasing the temperature can greatly reduce the analysis time. The thermal stability of all Discovery Zr phases allows temperatures up to 100°C and higher with special hardware. The separation of ß-blockers on Discovery Zr-CarbonC18 at 80°C in less than 1 minute is shown in the figure below. | ||||||||||||||||||||||||
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| PARTIONING AND SHAPE-SELECTIVE RETENTION MECHANISMS | ||||||||||||||||||||||||
| The separation of positional isomers of a proprietary sulfonamide drug is shown in the figure below. Here the parent compound is easily distinguished between its three corresponding positional isomers. | ||||||||||||||||||||||||
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| Ordering Information |
| Phase | ID (mm) | Length (cm) | Cat. No. |
| 3µm Discovery Zr-CarbonC18 Columns | |||
| 2.1 | 5 | 65701-U | |
| 2.1 | 7.5 | 65702-U | |
| 2.1 | 15 | 65703-U | |
| 4.6 | 5 | 65704-U | |
| 4.6 | 7.5 | 65705-U | |
| 4.6 | 15 | 65706-U | |
| 5µm Discovery Zr-CarbonC18 Columns | |||
| 2.1 | 5 | 65707-U | |
| 2.1 | 15 | 65708-U | |
| 4.6 | 5 | 65710-U | |
| 4.6 | 15 | 65711-U | |
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 For additional information, click the pdf icons below. |
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 Bulletin 932 - Discovery Zr: Method Development Guidlines (48 KB) |
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 Care and Use Guide for Discovery Zr-CarbonC18 (15 KB) |
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