Frequently Asked Questions

SupelMIP SPE is designed for the highly selective extraction of trace analytes in difficult sample matrices allowing researchers to reduce ion-suppression and achieve lower limits of quantitation. Although SupelMIP is a proven technology, additional method optimization and/or troubleshooting may be necessary to achieve method goals for your specific application.

For additional technical support, please fill out the Technical Support Request Form and a scientist skilled in molecularly imprinted polymer method development will contact you within 24 hours.

No. Process scale MIP products are not available through Supelco. Please contact MIP Technologies AB directly by visiting www.miptechnologies.com.

Because MIPs are tailor-made for individual analytes and analyte classes, analyte retention strength is increased significantly allowing for powerful wash steps within the SPE procedure. This allows for highly selective and simple extractions resulting in lower detection limits and improved MS compatibility (reduced ion-suppression). Each SupelMIP phase also comes with a detailed application specific protocol simplifying the method development process which in turn saves time and cost.

No. Existing protocols cannot be used. Every SupelMIP SPE includes a detailed extraction protocol that is analyte and matrix specific. This protocol needs to be used in order to achieve optimal retention during sample load, maximum interference removal during sample wash, and high recoveries during elution.

SupelMIP SPE consists of highly cross-linked polymers and can be used within the whole pH range (1-14) without loss of selectivity. Due to the high degree of cross-linking, minimal to no swelling and shrinking is observed. The shelf life of the packed tubes is consistent with traditional SPE technology (e.g., C18, PS/DVB, etc.).

If you think that your application merits the development of a molecularly imprinted polymer SPE application, you can submit a SupelMIP SPE Application Request Form. Scientists from both Supelco and MIP Technologies AB will evaluate your application through a short feasibility stage. If your application is prioritized to move through feasibility, the next stages will be development and optimization. The latter two stages can often take up to 8 months; however, we are in the process of streamlining how we develop and approach new SupelMIP applications.

SupelMIP SPE phases are manufactured by MIP Technologies AB. Each lot is subjected to stringent QC conditions to ensure low batch-to-batch variation. MIP based SPE technology is currently employed by a number of industrial and regulatory agencies for routine analysis. References from these organizations are available upon request.

Currently, our standard product consists of 25 mg bed weights packed in 3 mL and 10 mL LRC (large reservoir cartridges) SPE tubes. The phases can be custom packed in all other SPE hardware that Supelco offers (other SPE tube dimensions, glass SPE tubes, 96-well plates, etc.)