PRCP - prolylcarboxypeptidase (angiotensinase C)
Entrez Gene Name: prolylcarboxypeptidase (angiotensinase C)
Entrez GeneID: Human(5547)
, Mouse(72461), Rat(293118)
, Mouse(72461), Rat(293118) Synonyms: 2510048K03Rik, 2610104A14Rik, AI451719, angiotensinase C, HUMPCP, MGC2202, PCP, PRCP, PROLYLCARBOXYPEPTIDASE
Gene Summary
- Human (5547): The protein encoded by this gene is a lysosomal prolylcarboxypeptidase, which cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
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Literature References
- 10700174Ross DT, Scherf U, Eisen MB, Perou CM, Rees C, Spellman P, Iyer V, Jeffrey SS, Van de Rijn M, Waltham M, Pergamenschikov A, Lee JC, Lashkari D, Shalon D, Myers TG, Weinstein JN, Botstein D, Brown PO. Systematic variation in gene expression patterns in human cancer cell lines [see comments]Nat Genet 2000 Mar;24(3):227-35
- 14988562Odom DT, Zizlsperger N, Gordon DB, Bell GW, Rinaldi NJ, Murray HL, Volkert TL, Schreiber J, Rolfe PA, Gifford DK, Fraenkel E, Bell GI, Young RA. Control of pancreas and liver gene expression by HNF transcription factors.Science 2004 02 27;303(5662):1378-81
- 12393520Zhan F, Tian E, Bumm K, Smith R, Barlogie B, Shaughnessy J. Gene expression profiling of human plasma cell differentiation and classification of multiple myeloma based on similarities to distinct stages of late stage B-cell development.Blood 2003 02 1;101(3):1128-40 View 16 categorized literature findings and their references in IPA
Molecular Functions
carboxypeptidase activity, hydrolase activity, peptidase activity, serine-type peptidase activity, serine-type Pro-X carboxypeptidase activity
