CILP - cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
Entrez Gene Name: cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
Entrez GeneID: Human(8483)
, Mouse(214425), Rat(315761)
, Mouse(214425), Rat(315761) Synonyms: 9830114D16, C130036G17Rik, CILP, Cilp predicted, CILP-1, HsT18872
Gene Summary
- Human (8483): Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. This gene encodes the cartilage intermediate layer protein (CILP), which increases in early osteoarthrosis cartilage. The encoded protein was thought to encode a protein precursor for 2 different proteins, namely CILP and a homolog of NTPPHase, however later studies identified no nucleotide pyrophosphatase phosphodiesterase (NPP) activity. One isoform of the protein, CILP-1, functions as an IGF-1 antagonist.
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
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Cellular Components
extracellular matrix part, extracellular region, extracellular space, proteinaceous extracellular matrix
Literature References
- 15864306Seki S, Kawaguchi Y, Chiba K, Mikami Y, Kizawa H, Oya T, Mio F, Mori M, Miyamoto Y, Masuda I, Tsunoda T, Kamata M, Kubo T, Toyama Y, Kimura T, Nakamura Y, Ikegawa S. A functional SNP in CILP, encoding cartilage intermediate layer protein, is associated with susceptibility to lumbar disc disease.Nat Genet 2005 Jun 01;37(6):607-12
- 12775764Bethin KE, Nagai Y, Sladek R, Asada M, Sadovsky Y, Hudson TJ, Muglia LJ. Microarray analysis of uterine gene expression in mouse and human pregnancy.Mol Endocrinol 2003 Aug 01;17(8):1454-69
- 16948836Adachi J, Kumar C, Zhang Y, Olsen JV, Mann M. The human urinary proteome contains more than 1500 proteins including a large proportion of membranes proteins.Genome Biol 2006 09 01;7(9):R80 View 13 categorized literature findings and their references in IPA
